A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
Grantová podpora
Q40 04
Progres
PubMed
33956281
DOI
10.1007/s11239-021-02462-y
PII: 10.1007/s11239-021-02462-y
Knihovny.cz E-zdroje
- Klíčová slova
- Anticoagulation, Apixaban, Non-traumatic spinal epidural hematoma, Novel oral anticoagulants,
- MeSH
- antikoagulancia MeSH
- lidé MeSH
- lumbosakrální krajina MeSH
- magnetická rezonanční tomografie MeSH
- pyrazoly škodlivé účinky MeSH
- pyridony škodlivé účinky MeSH
- spinální epidurální hematom * chemicky indukované diagnostické zobrazování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- antikoagulancia MeSH
- apixaban MeSH Prohlížeč
- pyrazoly MeSH
- pyridony MeSH
Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs). These medications are supposed to have more predictable pharmacokinetics with fewer severe haemorrhagic adverse events in comparison with standard warfarin therapy. However, in the last few years, an increasing number of case reports have been published of haemorrhage into the central nervous system. We present a case of non-traumatic spinal epidural hematoma in the lumbar region in a patient on chronic apixaban therapy. To the best of our knowledge, it is the first described SSEH in the lumbar region associated with apixaban therapy.
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