In vitro activity of ceftazidime-avibactam and comparators against Enterobacterales and Pseudomonas aeruginosa isolates from Central Europe and Israel, 2014-2017 and 2018
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
34091111
DOI
10.1016/j.diagmicrobio.2021.115420
PII: S0732-8893(21)00113-9
Knihovny.cz E-zdroje
- Klíčová slova
- ATLAS, Ceftazidime-avibactam, Enterobacterales, Pseudomonas aeruginosa,
- MeSH
- antibakteriální látky farmakologie MeSH
- azabicyklické sloučeniny farmakologie MeSH
- bakteriální léková rezistence účinky léků MeSH
- ceftazidim farmakologie MeSH
- Enterobacteriaceae účinky léků izolace a purifikace MeSH
- enterobakteriální infekce mikrobiologie MeSH
- fixní kombinace léků MeSH
- inhibitory beta-laktamasy farmakologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- pseudomonádové infekce mikrobiologie MeSH
- Pseudomonas aeruginosa účinky léků izolace a purifikace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
- Izrael MeSH
- Názvy látek
- antibakteriální látky MeSH
- avibactam, ceftazidime drug combination MeSH Prohlížeč
- azabicyklické sloučeniny MeSH
- ceftazidim MeSH
- fixní kombinace léků MeSH
- inhibitory beta-laktamasy MeSH
Between 2014 and 2017, 6,662 Enterobacterales and 1,953 P. aeruginosa isolates were collected by 19 centers in four central European countries and Israel. A further 2,585 Enterobacterales and 707 P. aeruginosa isolates were collected in 2018 by 28 centers in seven European countries and Israel as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) study. A central laboratory performed antimicrobial susceptibility testing using broth microdilution panels according to Clinical Laboratory Standards Institute (CLSI) guidelines. Susceptibility rates among Enterobacterales were highest to ceftazidime-avibactam (≥98.5%), colistin (≥97.3%), and meropenem (≥95.8%). Ceftazidime-resistant and multidrug-resistant (MDR) Enterobacterales subsets were highly susceptible to ceftazidime-avibactam (≥94.9%) and colistin (≥94.7%). Susceptibility rates to colistin among all P. aeruginosa were ≥97.4% and were ≥96.3% among ceftazidime-resistant and MDR subsets. Susceptibility rates to ceftazidime-avibactam were 91.9% (2014-2017), 86.3% (2018) and, in common with comparator agents, were lower among ceftazidime-resistant (≥51.7%) and MDR isolates (≥57.1%).
Clinical Microbiology Laboratory Tel Aviv Sourasky Medical Centre Tel Aviv Israel
National Institute of Infectious Diseases 'Matei Bals' Bucharest Romania
Citace poskytuje Crossref.org
