Ethik der Reanimation und Entscheidungen am Lebensende: Leitlinien des European Resuscitation Council 2021
[Ethics of resuscitation and end of life decisions]

. 2021 ; 24 (4) : 720-749. [epub] 20210602

Status PubMed-not-MEDLINE Jazyk němčina Země Německo Médium print-electronic

Typ dokumentu anglický abstrakt, časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid34093076

These European Resuscitation Council Ethics guidelines provide evidence-based recommendations for the ethical, routine practice of resuscitation and end-of-life care of adults and children. The guideline primarily focus on major ethical practice interventions (i.e. advance directives, advance care planning, and shared decision making), decision making regarding resuscitation, education, and research. These areas are tightly related to the application of the principles of bioethics in the practice of resuscitation and end-of-life care.

UNLABELLED: Diese Ethikleitlinien des Europäischen Rats für Wiederbelebung enthalten evidenzbasierte Empfehlungen für die ethische, routinemäßige Praxis der Wiederbelebung und für die Betreuung von Erwachsenen und Kindern am Lebensende. Die Leitlinie konzentriert sich in erster Linie auf wichtige Maßnahmen in Bezug auf ethische Praktiken (d. h. Patientenverfügung, vorausschauende Behandlungsplanung* und gemeinsame Entscheidungsfindung), die Entscheidungsfindung in Bezug auf Wiederbelebung, Ausbildung und Forschung. Diese Bereiche stehen in engem Zusammenhang mit der Anwendung der Prinzipien der Bioethik in der Praxis der Wiederbelebung und der Betreuung am Lebensende. ZUSATZMATERIAL ONLINE: Zusätzliche Informationen sind in der Online-Version dieses Artikels (10.1007/s10049-021-00888-8) enthalten.

Zobrazit více v PubMed

Bavel JJV, Baicker K, Boggio PS, et al. Using social and behavioural science to support COVID-19 pandemic response. Nat Hum Behav. 2020;4:460–471. PubMed

Swire-Thompson B, Lazer D. Public health and online misinformation: challenges and recommendations. Annu Rev Public Health. 2020;41:433–451. PubMed

Perkins GD, Gräsner J‑T, Semeraro F, et al. Kurzfassung. Leitlinien des European Resuscitation Council 2021. Notfall Rettungsmed. 2021 doi: 10.1007/s10049-021-00883-z. PubMed DOI PMC

Nolan JP, Monsieurs KG, Bossaert L, et al. European Resuscitation Council COVID-19 guidelines executive summary. Resuscitation. 2020;153:45–55. PubMed PMC

Oczkowski SJ, Chung HO, Hanvey L, Mbuagbaw L, You JJ. Communication tools for end-of-life decision-making in ambulatory care settings: a systematic review and meta-analysis. PLoS ONE. 2016;11:e0150671. PubMed PMC

Higel T, Alaoui A, Bouton C, Fournier JP. Effect of living wills on end-of-life care: a systematic review. J Am Geriatr Soc. 2019;67:164–171. PubMed

Bossaert LL, Perkins GD, Askitopoulou H, et al. European Resuscitation Council guidelines for resuscitation 2015: section 11. The ethics of resuscitation and end-of-life decisions. Resuscitation. 2015;95:302–311. PubMed

Sprung CL, Truog RD, Curtis JR, et al. Seeking worldwide professional consensus on the principles of end-of-life care for the critically ill. The consensus for worldwide end-of-life practice for patients in intensive care units (WELPICUS) study. Am J Respir Crit Care Med. 2014;190(8):855–866. doi: 10.1164/rccm.201403-0593CC. PubMed DOI

Gilbert J, Boag J. Nonstandard advance health care directives in emergency departments: ethical and legal dilemma or reality: a narrative review. Adv Emerg Nurs J. 2018;40(4):324–327. doi: 10.1097/TME.0000000000000214. PubMed DOI

Martin DK, Emanuel LL, Singer PA. Planning for the end of life. Lancet. 2000;356(9242):1672–1676. doi: 10.1016/S0140-6736(00)03168-8. PubMed DOI

Santonocito C, Ristagno G, Gullo A, Weil MH. Do-not-resuscitate order: a view throughout the world. J Crit Care. 2013;28(1):14–21. doi: 10.1016/j.jcrc.2012.07.005. PubMed DOI

Mdel PV, Macchi MJ, Agranatti AF. Advance directives in the context of end-of-life palliative care. Curr Opin Support Palliat Care. 2013;7(4):406–410. doi: 10.1097/SPC.0000000000000007. PubMed DOI

Andorno R, Biller-Andorno N, Brauer S. Advance health care directives: towards a coordinated European policy? Eur J Health Law. 2009;16(3):207–227. PubMed

Kon AA, Davidson JE, Morrison W, et al. Shared decision making in ICUs: an American College of Critical Care Medicine and American Thoracic Society policy statement. Crit Care Med. 2016;44:188–201. PubMed PMC

Davidson JE, Aslakson RA, Long AC, et al. Guidelines for family-centered care in the neonatal, pediatric, and adult ICU. Crit Care Med. 2017;45:103–128. PubMed

Sutter R, Meyer-Zehnder B, Baumann SM, Marsch S, Pargger H. Advance directives in the neurocritically ill: a systematic review. Crit Care Med. 2020;48:1188–1195. PubMed

Becker C, Lecheler L, Hochstrasser S, et al. Association of communication interventions to discuss code status with patient decisions for do-not-resuscitate orders: a systematic review and meta-analysis. JAMA Netw Open. 2019;2:e195033. PubMed PMC

Houben CHM, Spruit MA, Groenen MTJ, Wouters EFM, Janssen DJA. Efficacy of advance care planning: a systematic review and meta-analysis. JAMA. 2014;15:477–489. PubMed

Brinkman-Stoppelenburg A, Rietjens JA, van der Heide A. The effects of advance care planning on end-of-life care: a systematic review. Palliat Med. 2014;28:1000–1025. PubMed

Field RA, Fritz Z, Baker A, Grove A, Perkins GD. Systematic review of interventions to improve appropriate use and outcomes associated with do-not-attempt-cardiopulmonary-resuscitation decisions. Resuscitation. 2014;85:1418–1431. PubMed

Reinhardt JP, Downes D, Cimarolli V, Bomba P. End-of-life conversations and hospice placement: association with less aggressive care desired in the nursing home. J Soc Work End Life Palliat Care. 2017;13:61–81. PubMed

Siewiera J, Tomaszewski D, Piechocki J, Kubler A. Withholding and withdrawing life-sustaining treatment: experiences in limiting futile therapy from three Polish intensive care departments. Adv Clin Exp Med. 2019;28:541–546. PubMed

Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017;356:j813. PubMed PMC

Mockford C, Fritz Z, George R, et al. Do not attempt cardiopulmonary resuscitation (DNACPR) orders: a systematic review of the barriers and facilitators of decision-making and implementation. Resuscitation. 2015;88:99–113. PubMed

Fokin AA, Wycech J, Katz JK, et al. Palliative care consultations in trauma patients and role of do-not-resuscitate orders: propensity-matched study. Am J Hosp Palliat Care. 2020;37:1068–1075. PubMed

Mitchell SL, Shaffer ML, Cohen S, Hanson LC, Habtemariam D, Volandes AE. An advance care planning video decision support tool for nursing home residents with advanced dementia: a cluster randomized clinical trial. JAMA Intern Med. 2018;178:961–969. PubMed PMC

El-Jawahri A, Mitchell SL, Paasche-Orlow MK, et al. A randomized controlled trial of a CPR and intubation video decision support tool for hospitalized patients. J Gen Intern Med. 2015;30:1071–1080. PubMed PMC

Merino AM, Greiner R, Hartwig K. A randomized controlled trial of a CPR decision support video for patients admitted to the general medicine service. J Hosp Med. 2017;12:700–704. PubMed

Cappell K, Sundaram V, Park A, et al. Advance directive utilization is associated with less aggressive end-of-life care in patients undergoing allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2018;24:1035–1040. PubMed PMC

Fu PK, Tung YC, Wang CY, et al. Early and late do-not-resuscitate (DNR) decisions in patients with terminal COPD: a retrospective study in the last year of life. Int J Chron Obstruct Pulmon Dis. 2018;13:2447–2454. PubMed PMC

Stream S, Nolan A, Kwon S, Constable C. Factors associated with combined do-not-resuscitate and do-not-intubate orders: a retrospective chart review at an urban tertiary care center. Resuscitation. 2018;130:1–5. PubMed PMC

Reuter PG, Agostinucci JM, Bertrand P, et al. Prevalence of advance directives and impact on advanced life support in out-of-hospital cardiac arrest victims. Resuscitation. 2017;116:105–108. PubMed

Kuchinad KE, Strowd R, Evans A, Riley WA, Smith TJ. End of life care for glioblastoma patients at a large academic cancer center. J Neurooncol. 2017;134:75–81. PubMed

Mills A, Walker A, Levinson M, et al. Resuscitation orders in acute hospitals: a point prevalence study. Australas J Ageing. 2017;36:32–37. PubMed

McCarroll CM. Increasing access to palliative care services in the intensive care unit. Dimens Crit Care Nurs. 2018;37:180–192. PubMed

MacKenzie MA, Smith-Howell E, Bomba PA, Meghani SH. Respecting choices and related models of advance care planning: a systematic review of published evidence. Am J Hosp Palliat Care. 2018;35:897–907. PubMed PMC

O’Halloran P, Noble H, Norwood K, et al. Advance care planning with patients who have end-stage kidney disease: a systematic realist review. J Pain Symptom Manage. 2018;56:795–807.e18. PubMed PMC

Voss H, Vogel A, Wagemans AMA, et al. Advance care planning in palliative care for people with intellectual disabilities: a systematic review. J Pain Symptom Manage. 2017;54:938–960.e1. PubMed

Weathers E, O’Caoimh R, Cornally N, et al. Advance care planning: a systematic review of randomised controlled trials conducted with older adults. Maturitas. 2016;91:101–109. PubMed

Martin RS, Hayes B, Gregorevic K, Lim WK. The effects of advance care planning interventions on nursing home residents: a systematic review. JAMA. 2016;17:284–293. PubMed

Lim CE, Ng RW, Cheng NC, Cigolini M, Kwok C, Brennan F. Advance care planning for haemodialysis patients. Cochrane Database Syst Rev. 2016;7:CD010737. PubMed PMC

Nair R, Kohen SA. Can a patient-directed video improve inpatient advance care planning? A prospective pre-post cohort study. BMJ Qual Saf. 2019;28:887–893. PubMed PMC

Wen FH, Chen JS, Chou WC, Chang WC, Hsieh CH, Tang ST. Extent and determinants of terminally ill cancer patients’ concordance between preferred and received life-sustaining treatment states: an advance care planning randomized trial in Taiwan. J Pain Symptom Manage. 2019;58(1):1–10.e10. PubMed

Jennings LA, Turner M, Keebler C, et al. The effect of a comprehensive dementia care management program on end-of-life care. J Am Geriatr Soc. 2019;67:443–448. PubMed PMC

Malhotra C, Sim D, Jaufeerally FR, et al. Impact of a formal advance care planning program on end-of-life care for patients with heart failure: results from a randomized controlled trial. J Card Fail. 2020;26:594–598. PubMed

Walczak A, Butow PN, Bu S, Clayton JM. A systematic review of evidence for end-of-life communication interventions: Who do they target, how are they structured and do they work? Patient Educ Couns. 2016;99:3–16. PubMed

Kavalieratos D, Corbelli J, Zhang D, et al. Association between palliative care and patient and caregiver outcomes: a systematic review and meta-analysis. JAMA. 2016;316:2104–2114. PubMed PMC

Huber MT, Highland JD, Krishnamoorthi VR, Tang JW. Utilizing the electronic health record to improve advance care planning: a systematic review. Am J Hosp Palliat Care. 2018;35:532–541. PubMed

Kang E, Lee J, Choo J, Min J, Yun YH. Randomized controlled trial of advance care planning video decision aid for the general population. J Pain Symptom Manage. 2020;59:1239–1247. PubMed

Nedjat-Haiem FR, Cadet TJ, Amatya A, Thompson B, Mishra SI. Efficacy of motivational interviewing to enhance advance directive completion in latinos with chronic illness: a randomized controlled trial. Am J Hosp Palliat Care. 2019;36:980–992. PubMed

Denis N, Timsit JF, Giaj Levra M, et al. Impact of systematic advanced care planning in lung cancer patients: a prospective study. Respir Med. 2020;77:11–17. PubMed

Jain A, Corriveau S, Quinn K, Gardhouse A, Vegas DB, You JJ. Video decision aids to assist with advance care planning: a systematic review and meta-analysis. BMJ Open. 2015;5:e007491. PubMed PMC

Oczkowski SJ, Chung HO, Hanvey L, Mbuagbaw L, You JJ. Communication tools for end-of-life decision-making in the intensive care unit: a systematic review and meta-analysis. Crit Care. 2016;20:97. PubMed PMC

El-Jawahri A, Paasche-Orlow MK, Matlock D, et al. Randomized, controlled trial of an advance care planning video decision support tool for patients with advanced heart failure. Circulation. 2016;134:52–60. PubMed PMC

Chan HY, Ng JS, Chan KS, et al. Effects of a nurse-led post-discharge advance care planning programme for community-dwelling patients nearing the end of life and their family members: a randomised controlled trial. Int J Nurs Stud. 2018;87:26–33. PubMed

Green MJ, Van Scoy LJ, Foy AJ, Dimmock AEF, Lehman E, Levi BH. Patients with advanced cancer choose less aggressive medical treatment on vignettes after using a computer-based decision aid. Am J Hosp Palliat Care. 2020;37:537–541. PubMed

Kizawa Y, Okada H, Kawahara T, Morita T. Effects of brief nurse advance care planning intervention with visual materials on goal-of-care preference of Japanese elderly patients with chronic disease: a pilot randomized-controlled trial. J Palliat Med. 2020;23:1076–1083. PubMed

DeCourcey DD, Silverman M, Oladunjoye A, Wolfe J. Advance care planning and parent-reported end-of-life outcomes in children, adolescents, and young adults with complex chronic conditions. Crit Care Med. 2019;47:101–108. PubMed

Kernick LA, Hogg KJ, Millerick Y, Murtagh FEM, Djahit A, Johnson M. Does advance care planning in addition to usual care reduce hospitalisation for patients with advanced heart failure: a systematic review and narrative synthesis. Palliat Med. 2018;32:1539–1551. PubMed

Klingler C, in der Schmitten J, Marckmann G. Does facilitated advance care planning reduce the costs of care near the end of life? Systematic review and ethical considerations. Palliat Med. 2016;30:423–433. PubMed PMC

Overbeek A, Polinder S, Haagsma J, et al. Advance care planning for frail older adults: findings on costs in a cluster randomised controlled trial. Palliat Med. 2019;33:291–300. PubMed

Scarpi E, Dall’Agata M, Zagonel V, et al. Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes. Support Care Cancer. 2019;27:2425–2434. PubMed

Pedraza SL, Culp S, Knestrick M, Falkenstine E, Moss AH. Association of physician orders for life-sustaining treatment form use with end-of-life care quality metrics in patients with cancer. J Oncol Pract. 2017;13:e881–e888. PubMed

Thomas P, Hazif-Thomas C. Discourse on life and Alzheimer’s disease. Soins Gerontol. 2018;23:31–33. PubMed

Hoell JI, Weber HL, Balzer S, et al. Advance care planning and outcome in pediatric palliative home care. Oncotarget. 2018;9:17867–17875. PubMed PMC

Chong PH, De Castro Molina JA, Teo K, Tan WS. Paediatric palliative care improves patient outcomes and reduces healthcare costs: evaluation of a home-based program. BMC Palliat Care. 2018;17:11. PubMed PMC

Suraarunsumrit P, Nopmaneejumruslers C, Srinonprasert V. Advance care planning (ACP) associated with reduced health care utilization in deceased older patients with advanced stage of chronic diseases. J Med Assoc Thai. 2019;102:801–808.

Marsac ML, Kindler C, Weiss D, Ragsdale L. Let’s talk about it: supporting family communication during end-of-life care of pediatric patients. J Palliat Med. 2018;21:862–878. PubMed

Walczak A, Butow PN, Tattersall MH, et al. Encouraging early discussion of life expectancy and end-of-life care: a randomised controlled trial of a nurse-led communication support program for patients and caregivers. Int J Nurs Stud. 2017;67:31–40. PubMed

Overbeek A, Korfage IJ, Jabbarian LJ, et al. Advance care planning in frail older adults: a cluster randomized controlled trial. J Am Geriatr Soc. 2018;66:1089–1095. PubMed

Brazil K, Carter G, Cardwell C, et al. Effectiveness of advance care planning with family carers in dementia nursing homes: a paired cluster randomized controlled trial. Palliat Med. 2018;32:603–612. PubMed

Mentzelopoulos SD, Slowther AM, Fritz Z, et al. Ethical challenges in resuscitation. Intensive Care Med. 2018;44:703–716. PubMed

Gonella S, Basso I, Dimonte V, et al. Association between end-of-life conversations in nursing homes and end-of-life care outcomes: a systematic review and meta-analysis. JAMA. 2019;20:249–261. PubMed

Allen LA, McIlvennan CK, Thompson JS, et al. Effectiveness of an intervention supporting shared decision making for destination therapy left ventricular assist device: the DECIDE-LVAD randomized clinical trial. JAMA Intern Med. 2018;178:520–529. PubMed PMC

Hanson LC, Zimmerman S, Song MK, et al. Effect of the goals of care intervention for advanced dementia: a randomized clinical trial. JAMA Intern Med. 2017;177:24–31. PubMed PMC

DeMartino ES, Braus NA, Sulmasy DP, et al. Decisions to withdraw extracorporeal membrane oxygenation support: patient characteristics and ethical considerations. Mayo Clin Proc. 2019;94:620–627. PubMed PMC

Hsu NC, Huang CC, Chen WC, Yu CJ. Impact of patient-centred and family-centred care meetings on intensive care and resource utilisation in patients with terminal illness: a single-centre retrospective observational study in Taiwan. BMJ Open. 2019;9:e021561. PubMed PMC

Wilson ME, Krupa A, Hinds RF, et al. A video to improve patient and surrogate understanding of cardiopulmonary resuscitation choices in the ICU: a randomized controlled trial. Crit Care Med. 2015;43:621–629. PubMed

Chen C, Michaels J, Meeker MA. Family outcomes and perceptions of end-of-life care in the intensive care unit: a mixed-methods review. J Palliat Care. 2020;35:143–153. PubMed

Lee HW, Park Y, Jang EJ, Lee YJ. Intensive care unit length of stay is reduced by protocolized family support intervention: a systematic review and meta-analysis. Intensive Care Med. 2019;45:1072–1081. PubMed

Martin RS, Hayes BJ, Hutchinson A, Tacey M, Yates P, Lim WK. Introducing goals of patient care in residential aged care facilities to decrease hospitalization: a cluster randomized controlled trial. JAMA. 2019;20:1318–1324.e2. PubMed

Hinkle LJ, Bosslet GT, Torke AM. Factors associated with family satisfaction with end-of-life care in the ICU: a systematic review. Chest. 2015;147:82–93. PubMed

White DB, Angus DC, Shields AM, et al. A randomized trial of a family-support intervention in intensive care units. N Engl J Med. 2018;378:2365–2375. PubMed

Curtis JR, Treece PD, Nielsen EL, et al. Randomized trial of communication facilitators to reduce family distress and intensity of end-of-life care. Am J Respir Crit Care Med. 2016;193:154–162. PubMed PMC

Curtis JR, Nielsen EL, Treece PD, et al. Effect of a quality-improvement intervention on end-of-life care in the intensive care unit: a randomized trial. Am J Respir Crit Care Med. 2011;183:348–355. PubMed PMC

Sulmasy DP, Hughes MT, Yenokyan G, et al. The trial of ascertaining individual preferences for loved ones’ role in end-of-life decisions (TAILORED) study: a randomized controlled trial to improve surrogate decision making. J Pain Symptom Manage. 2017;54:455–465. PubMed PMC

Carson SS, Cox CE, Wallenstein S, et al. Effect of palliative care-led meetings for families of patients with chronic critical illness: a randomized clinical trial. JAMA. 2016;316:51–62. PubMed PMC

Lautrette A, Darmon M, Megarbane B, et al. A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med. 2007;356:469–478. PubMed

Davidson JE, Jones C, Bienvenu OJ. Family response to critical illness: postintensive care syndrome-family. Crit Care Med. 2012;40:618–624. PubMed

Adelman RD, Tmanova LL, Delgado D, Dion S, Lachs MS. Caregiver burden: a clinical review. JAMA. 2014;311:1052–1060. PubMed

DeSanto-Madeya S, Safizadeh P. Family satisfaction with end-of-life care in the intensive care unit: a systematic review of the literature. Dimens Crit Care Nurs. 2017;36:278–283. PubMed

You JJ, Jayaraman D, Swinton M, Jiang X, Heyland DK. Supporting shared decision-making about cardiopulmonary resuscitation using a video-based decision-support intervention in a hospital setting: a multisite before-after pilot study. CMAJ Open. 2019;7:E630–E637. PubMed PMC

Sahgal S, Yande A, Thompson BB, et al. Surrogate satisfaction with decision making after intracerebral hemorrhage. Neurocrit Care. 2021;34(1):193–200. PubMed PMC

Scheunemann LP, Ernecoff NC, Buddadhumaruk P, et al. Clinician-family communication about patients’ values and preferences in intensive care units. JAMA Intern Med. 2019;179:676–684. PubMed PMC

Farrell TW, Ferrante LE, Brown T, et al. AGS position statement: resource allocation strategies and age-related considerations in the COVID-19 era and beyond. J Am Geriatr Soc. 2020;68:1136–1142. PubMed PMC

Farrell TW, Francis L, Brown T, et al. Rationing limited healthcare resources in the COVID-19 era and beyond: ethical considerations regarding older adults. J Am Geriatr Soc. 2020;68:1143–1149. PubMed PMC

Block BL, Smith AK, Sudore RL. During COVID-19, outpatient advance care planning is imperative: we need all hands on deck. J Am Geriatr Soc. 2020;68:1395–1397. PubMed PMC

Zheng RJ, Fu Y, Xiang QF, et al. Knowledge, attitudes, and influencing factors of cancer patients toward approving advance directives in China. Support Care Cancer. 2016;24:4097–4103. PubMed PMC

Hopkins SA, Lovick R, Polak L, et al. Reassessing advance care planning in the light of covid-19. BMJ. 2020;369:m1927. PubMed

Bledsoe TA, Jokela JA, Deep NN, Snyder Sulmasy L. Universal do-not-resuscitate orders, social worth, and life-years: opposing discriminatory approaches to the allocation of resources during the COVID-19 pandemic and other health system catastrophes. Ann Intern Med. 2020;173:230–232. PubMed PMC

White DB, Lo B. A framework for rationing ventilators and critical care beds during the COVID-19 pandemic. JAMA. 2020;323:1773–1774. PubMed

Mentzelopoulos SD, Bossaert L, Greif R. Coronavirus disease 2019 and ethical considerations for extracorporeal cardiopulmonary resuscitation. Resuscitation. 2020;154:127–128. PubMed PMC

Lee J, Abrukin L, Flores S, et al. Early intervention of palliative care in the emergency department during the COVID-19 pandemic. JAMA Intern Med. 2020;180:1252–1254. PubMed PMC

Greif R, Bhanji F, Bigham BL, et al. Education, implementation, and teams: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2020;156:A188–A239. PubMed

Pellegrino ED. Is it ethical to withdraw low-burden interventions in chronically ill patients? JAMA. 2000;284:1380–1382. PubMed

Druwe P, Monsieurs KG, Piers R, et al. Perception of inappropriate cardiopulmonary resuscitation by clinicians working in emergency departments and ambulance services: the REAPPROPRIATE international, multi-centre, cross sectional survey. Resuscitation. 2018;132:112–119. PubMed

Munoz MG, Beyda DH. An ethical justification for termination of resuscitation protocols for pediatric patients. Pediatr Emerg Care. 2017;33:505–515. PubMed

Ranola PA, Merchant RM, Perman SM, et al. How long is long enough, and have we done everything we should?—Ethics of calling codes. J Med Ethics. 2015;41:663–666. PubMed PMC

Mercurio MR, Murray PD, Gross I. Unilateral pediatric “do not attempt resuscitation” orders: the pros, the cons, and a proposed approach. Pediatrics. 2014;133(Suppl 1):S37–S43. PubMed

Weise KL, Okun AL, Carter BS, et al. Guidance on forgoing life-sustaining medical treatment. Pediatrics. 2017;140(3):e20171905. PubMed

Javaudin F, Le Bastard Q, Lascarrou JB, et al. The futility of resuscitating an out-of-hospital cardiac arrest cannot be summarized by three simple criteria. Resuscitation. 2019;144:199–200. PubMed

Grunau B, Scheuermeyer F, Kawano T, et al. North American validation of the Bokutoh criteria for withholding professional resuscitation in non-traumatic out-of-hospital cardiac arrest. Resuscitation. 2019;135:51–56. PubMed

Rosoff PM, Schneiderman LJ. Irrational exuberance: cardiopulmonary resuscitation as fetish. Am J Bioeth. 2017;17:26–34. PubMed

Druwe P, Benoit DD, Monsieurs KG, et al. Cardiopulmonary resuscitation in adults over 80: outcome and the perception of appropriateness by clinicians. J Am Geriatr Soc. 2020;68:39–45. PubMed

Van Norman GA. Decisions regarding forgoing life-sustaining treatments. Curr Opin Anaesthesiol. 2017;30:211–216. PubMed

Ting PS, Chen L, Yang WC, Huang TS, Wu CC, Chen YY. Gender and age disparity in the initiation of life-supporting treatments: a population-based cohort study. BMC Med Ethics. 2017;18:62. PubMed PMC

Chiang WC, Ko PC, Chang AM, et al. Bystander-initiated CPR in an Asian metropolitan: Does the socioeconomic status matter? Resuscitation. 2014;85:53–58. PubMed PMC

Ahaddour C, Van den Branden S, Broeckaert B. Between quality of life and hope. Attitudes and beliefs of Muslim women toward withholding and withdrawing life-sustaining treatments. Med Health Care Philos. 2018;21:347–361. PubMed

Chamsi-Pasha H, Albar MA. Do not resuscitate, brain death, and organ transplantation: Islamic perspective. Avicenna J Med. 2017;7:35–45. PubMed PMC

Hansen C, Lauridsen KG, Schmidt AS, Lofgren B. Decision-making in cardiac arrest: physicians’ and nurses’ knowledge and views on terminating resuscitation. Open Access Emerg Med. 2019;11:1–8. PubMed PMC

Waldrop DP, Waldrop MR, McGinley JM, Crowley CR, Clemency B. Prehospital providers’ perspectives about online medical direction in emergency end-of-life decision-making. Prehosp Emerg Care. 2021 doi: 10.1080/10903127.2020.1863532. PubMed DOI

Kang M, Kim J, Kim K. Resuscitation duration inequality by patient characteristics in emergency department out-of-hospital cardiac arrest: an observational study. Clin Exp Emerg Med. 2014;1:87–93. PubMed PMC

Wiel E, Di Pompeo C, Segal N, et al. Age discrimination in out-of-hospital cardiac arrest care: a case-control study. Eur J Cardiovasc Nurs. 2018;17:505–512. PubMed

Teefy J, Cram N, Van Zyl T, Van Aarsen K, McLeod S, Dukelow A. Evaluation of the uptake of a prehospital cardiac arrest termination of resuscitation rule. J Emerg Med. 2020;58:254–259. PubMed

Ozer J, Alon G, Leykin D, Varon J, Aharonson-Daniel L, Einav S. Culture and personal influences on cardiopulmonary resuscitation—results of international survey. BMC Med Ethics. 2019;20:102. PubMed PMC

Long AC, Brumback LC, Curtis JR, et al. Agreement with consensus statements on end-of-life care: a description of variability at the level of the provider, hospital, and country. Crit Care Med. 2019;47:1396–1401. PubMed PMC

Wang CH, Chang WT, Huang CH, et al. Factors associated with the decision to terminate resuscitation early for adult in-hospital cardiac arrest: influence of family in an East Asian society. PLoS ONE. 2019;14:e0213168. PubMed PMC

Brooks SC, Schmicker RH, Cheskes S, et al. Variability in the initiation of resuscitation attempts by emergency medical services personnel during out-of-hospital cardiac arrest. Resuscitation. 2017;117:102–108. PubMed PMC

Phua J, Joynt GM, Nishimura M, et al. Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions. Intensive Care Med. 2016;42:1118–1127. PubMed

Campwala RT, Schmidt AR, Chang TP, Nager AL. Factors influencing termination of resuscitation in children: a qualitative analysis. Int J Emerg Med. 2020;13:12. PubMed PMC

Obladen M. Despising the weak: long shadows of infant murder in Nazi Germany. Arch Dis Child Fetal Neonatal Ed. 2016;101:F190–F194. PubMed

Brick C, Kahane G, Wilkinson D, Caviola L, Savulescu J. Worth living or worth dying? The views of the general public about allowing disabled children to die. J Med Ethics. 2020;46:7–15. PubMed PMC

Tibballs J. Legal basis for ethical withholding and withdrawing life-sustaining medical treatment from infants and children. J Paediatr Child Health. 2007;43:230–236. PubMed

Welbourn C, Efstathiou N. How does the length of cardiopulmonary resuscitation affect brain damage in patients surviving cardiac arrest? A systematic review. Scand J Trauma Resusc Emerg Med. 2018;26:77. PubMed PMC

Morrison LJ. Prehospital termination of resuscitation rule. Curr Opin Crit Care. 2019;25:199–203. PubMed

Grunau B, Reynolds JC, Scheuermeyer FX, et al. Comparing the prognosis of those with initial shockable and non-shockable rhythms with increasing durations of CPR: informing minimum durations of resuscitation. Resuscitation. 2016;101:50–56. PubMed

Matsuyama T, Kitamura T, Kiyohara K, et al. Impact of cardiopulmonary resuscitation duration on neurologically favourable outcome after out-of-hospital cardiac arrest: a population-based study in Japan. Resuscitation. 2017;113:1–7. PubMed

Goto Y, Funada A, Goto Y. Relationship between the duration of cardiopulmonary resuscitation and favorable neurological outcomes after out-of-hospital cardiac arrest: a prospective, nationwide, population-based cohort study. J Am Heart Assoc. 2016;5:e002819. PubMed PMC

Chien CY, Su YC, Lin CC, Kuo CW, Lin SC, Weng YM. Is 15 min an appropriate resuscitation duration before termination of a traumatic cardiac arrest? A case-control study. Am J Emerg Med. 2016;34:505–509. PubMed

Murakami N, Kokubu N, Nagano N, et al. Prognostic impact of no-flow time on 30-day neurological outcomes in patients with out-of-hospital cardiac arrest who received extracorporeal cardiopulmonary resuscitation. Circ J. 2020;84:1097–1104. PubMed

Drennan IR, Case E, Verbeek PR, et al. A comparison of the universal TOR guideline to the absence of prehospital ROSC and duration of resuscitation in predicting futility from out-of-hospital cardiac arrest. Resuscitation. 2017;111:96–102. PubMed PMC

Nagata T, Abe T, Hasegawa M, Hagihara A. Factors associated with the outcome of out-of-hospital cardiopulmonary arrest among people over 80 years old in Japan. Resuscitation. 2017;113:63–69. PubMed

Petek BJ, Bennett DN, Ngo C, et al. Reexamination of the UN10 rule to discontinue resuscitation during in-hospital cardiac arrest. JAMA Netw Open. 2019;2:e194941. PubMed PMC

Cheung BH, Mercer MP. Prehospital disposition and patient outcomes in cardiac arrest AFTER resuscitation termination protocol change in an urban setting. Prehosp Disaster med. 2020;35:285–292. PubMed

Hreinsson JP, Thorvaldsson AP, Magnusson V, Fridriksson BT, Libungan BG, Karason S. Identifying out-of-hospital cardiac arrest patients with no chance of survival: an independent validation of prediction rules. Resuscitation. 2020;146:19–25. PubMed

Winther-Jensen M, Kjaergaard J, Hassager C, et al. Resuscitation and post resuscitation care of the very old after out-of-hospital cardiac arrest is worthwhile. Int J Cardiol. 2015;201:616–623. PubMed

Funada A, Goto Y, Maeda T, Teramoto R, Hayashi K, Yamagishi M. Improved survival with favorable neurological outcome in elderly individuals with out-of-hospital cardiac arrest in Japan—a nationwide observational cohort study. Circ J. 2016;80:1153–1162. PubMed

Fernando SM, Qureshi D, Tanuseputro P, et al. Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children—a population-based cohort study. Crit Care. 2020;24:131. PubMed PMC

Smith RJ, Reid DA, Santamaria JD. Frailty is associated with reduced prospect of discharge home after in-hospital cardiac arrest. Intern Med J. 2019;49:978–985. PubMed

Nas J, Kleinnibbelink G, Hannink G, et al. Diagnostic performance of the basic and advanced life support termination of resuscitation rules: a systematic review and diagnostic meta-analysis. Resuscitation. 2020;148:3–13. PubMed

Ebell MH, Vellinga A, Masterson S, Yun P. Meta-analysis of the accuracy of termination of resuscitation rules for out-of-hospital cardiac arrest. Emerg Med J. 2019;36:479–484. PubMed

Verhaert DV, Bonnes JL, Nas J, et al. Termination of resuscitation in the prehospital setting: a comparison of decisions in clinical practice vs. recommendations of a termination rule. Resuscitation. 2016;100:60–65. PubMed

American College of Surgeons Committee on Trauma. American College of Emergency Physicians Pediatric Emergency Medicin. National Association of EMS Physicians. American Academy of Pediatrics Committee on Pediatric Emergency Medicine. Fallat ME. Withholding or termination of resuscitation in pediatric out-of-hospital traumatic cardiopulmonary arrest. Ann Emerg Med. 2014;63(4):504–515. PubMed

Rotering VM, Trepels-Kottek S, Heimann K, Brokmann JC, Orlikowsky T, Schoberer M. Adult “termination-of-resuscitation” (TOR)-criteria may not be suitable for children—a retrospective analysis. Scand J Trauma Resusc Emerg Med. 2016;24:144. PubMed PMC

Shibahashi K, Sugiyama K, Hamabe Y. Pediatric out-of-hospital traumatic cardiopulmonary arrest after traffic accidents and termination of resuscitation. Ann Emerg Med. 2020;75:57–65. PubMed

Clark JD, Dudzinski DM. The culture of dysthanasia: attempting CPR in terminally ill children. Pediatrics. 2013;131:572–580. PubMed

Ganz FD, Sharfi R, Kaufman N, Einav S. Perceptions of slow codes by nurses working on internal medicine wards. Nurs Ethics. 2019;26:1734–1743. PubMed

Einav S, Avidan A, Brezis M, Rubinow A. Attitudes of medical practitioners towards “Do Not Resuscitate” orders. Med Law. 2006;25:219–228. PubMed

Vandeplassche S, van de Voorde P. Retrospective population-based study of emergency medical services-attended out-of-hospital cardiac arrests in children in Belgium. Eur J Emerg Med. 2018;25:400–403. PubMed

Kelly J. Literature review: decision-making regarding slow resuscitation. J Clin Nurs. 2007;16:1989–1996. PubMed

Kelly J. Nurses’ and doctors’ perspectives on slow codes. Nurs Ethics. 2008;15:110–120. PubMed

Soar J, Berg KM, Andersen LW, et al. Adult advanced life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2020;156:A80–A119. PubMed PMC

Maconochie IK, Aickin R, Hazinski MF, et al. Pediatric life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2020;156:A120–A155. PubMed PMC

D’Arrigo S, Cacciola S, Dennis M, et al. Predictors of favourable outcome after in-hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation: a systematic review and meta-analysis. Resuscitation. 2017;121:62–70. PubMed

Ortega-Deballon I, Hornby L, Shemie SD, Bhanji F, Guadagno E. Extracorporeal resuscitation for refractory out-of-hospital cardiac arrest in adults: a systematic review of international practices and outcomes. Resuscitation. 2016;101:12–20. PubMed

Harvey MJ, Gaies MG, Prosser LA. U.S. and international in-hospital costs of extracorporeal membrane oxygenation: a systematic review. Appl Health Econ Health Policy. 2015;13:341–357. PubMed

Holmberg MJ, Geri G, Wiberg S, et al. Extracorporeal cardiopulmonary resuscitation for cardiac arrest: a systematic review. Resuscitation. 2018;131:91–100. PubMed PMC

Bougouin W, Dumas F, Lamhaut L, et al. Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a registry study. Eur Heart J. 2020;41:1961–1971. PubMed

Ontario Health (Quality) Extracorporeal membrane oxygenation for cardiac indications in adults: a health technology assessmen. Ont Health Technol Assess Ser. 2020;20:1–121. PubMed PMC

Grunau B, Hornby L, Singal RK, et al. Extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: the state of the evidence and framework for application. Can J Cardiol. 2018;34:146–155. PubMed

Dalle Ave AL, Shaw DM, Gardiner D. Extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation or uncontrolled donation after the circulatory determination of death following out-of-hospital refractory cardiac arrest-An ethical analysis of an unresolved clinical dilemma. Resuscitation. 2016;108:87–94. PubMed

Pujara D, Sandoval E, Simpson L, Mallidi HR, Singh SK. The state of the art in extracorporeal membrane oxygenation. Semin Thorac Cardiovasc Surg. 2015;27:17–23. PubMed

Singer B, Reynolds JC, Lockey DJ, O’Brien B. Pre-hospital extra-corporeal cardiopulmonary resuscitation. Scand J Trauma Resusc Emerg Med. 2018;26:21. PubMed PMC

Gravesteijn BY, Schluep M, Voormolen DC, et al. Cost-effectiveness of extracorporeal cardiopulmonary resuscitation after in-hospital cardiac arrest: a Markov decision model. Resuscitation. 2019;143:150–157. PubMed

Meltzer EC, Ivascu NS, Stark M, et al. A survey of physicians’ attitudes toward decision-making authority for initiating and withdrawing VA-ECMO: results and ethical implications for shared decision making. J Clin Ethics. 2016;27:281–289. PubMed PMC

St-Onge M, Fan E, Megarbane B, Hancock-Howard R, Coyte PC. Venoarterial extracorporeal membrane oxygenation for patients in shock or cardiac arrest secondary to cardiotoxicant poisoning: a cost-effectiveness analysis. J Crit Care. 2015;30:437.e7–437.e14. PubMed

Dennis M, Zmudzki F, Burns B, et al. Cost effectiveness and quality of life analysis of extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest. Resuscitation. 2019;139:49–56. PubMed

Tonna JE, Selzman CH, Girotra S, et al. Patient and institutional characteristics influence the decision to use extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest. J Am Heart Assoc. 2020;9:e015522. PubMed PMC

Poppe M, Schriefl C, Steinacher A, et al. Extracorporeal cardiopulmonary resuscitation at the emergency department: a retrospective patient selection evaluation. Eur J Anaesthesiol. 2020;37:280–285. PubMed

Yoshida T, Fujitani S, Wakatake H, et al. Exploratory observational study of extracorporeal cardiopulmonary resuscitation for nonshockable out-of-hospital cardiac arrest occurring after an emergency medical services arrival: SOS-KANTO 2012 study report. J Emerg Med. 2020;58:375–384. PubMed

Lunz D, Calabro L, Belliato M, et al. Extracorporeal membrane oxygenation for refractory cardiac arrest: a retrospective multicenter study. Intensive Care Med. 2020;46:973–982. PubMed

Chonde M, Escajeda J, Elmer J, et al. Challenges in the development and implementation of a healthcare system based extracorporeal cardiopulmonary resuscitation (ECPR) program for the treatment of out of hospital cardiac arrest. Resuscitation. 2020;148:259–265. PubMed

McDonald L, Mastoras G, Hickey M, McDonald B, Kwok ESH. Evaluating the potential impact of an emergency department extracorporeal resuscitation (ECPR) program: a health records review. CJEM. 2020;22:375–378. PubMed

Cheetham OV, Thomas MJ, Hadfield J, O’Higgins F, Mitchell C, Rooney KD. Rates of organ donation in a UK tertiary cardiac arrest centre following out-of-hospital cardiac arrest. Resuscitation. 2016;101:41–43. PubMed

Nolan JP, Ferrando P, Soar J, et al. Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation. Crit Care. 2016;20:219. PubMed PMC

Sandroni C, D’Arrigo S, Callaway CW, et al. The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis. Intensive Care Med. 2016;42:1661–1671. PubMed PMC

Nolan JP, Sandroni C, Böttiger BW, et al. Postreanimationsbehandlung. Leitlinien des European Resuscitation Council und der European Society of Intensive Care Medicine 2021. Notfall Rettungsmed. 2021 doi: 10.1007/s10049-021-00892-y. DOI

Soar J, Böttiger BW, Carli P, et al. Erweiterte lebensrettende Maßnahmen für Erwachsene. Leitlinien des European Resuscitation Council 2021. Notfall Rettungsmed. 2021 doi: 10.1007/s10049-021-00893-x. PubMed DOI PMC

Ortega-Deballon I, Hornby L, Shemie SD. Protocols for uncontrolled donation after circulatory death: a systematic review of international guidelines, practices and transplant outcomes. Crit Care. 2015;19:268. PubMed PMC

DuBois JM, Anderson EE. Attitudes toward death criteria and organ donation among healthcare personnel and the general public. Prog Transplant. 2006;16:65–73. PubMed

Shah SK, Kasper K, Miller FG. A narrative review of the empirical evidence on public attitudes on brain death and vital organ transplantation: the need for better data to inform policy. J Med Ethics. 2015;41:291–296. PubMed

Escudero D, Otero J, Menéndez de León B, Perez-Basterrechea M. Organ donation and elective ventilation: a necessary strategy. Biomed Res Int. 2017;2017:7518375. PubMed PMC

Dalle Ave AL, Gardiner D, Shaw DM. Cardio-pulmonary resuscitation of brain-dead organ donors: a literature review and suggestions for practice. Transpl Int. 2016;29:12–19. PubMed

Weiss MJ, English SW, D’Aragon F, et al. Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation. Can J Anaesth. 2020;67:313–323. PubMed

Reed MJ, Lua SB. Uncontrolled organ donation after circulatory death: potential donors in the emergency department. Emerg Med J. 2014;31:741–744. PubMed

Bruce CM, Reed MJ, MacDougall M. Are the public ready for organ donation after out of hospital cardiac arrest? Emerg Med J. 2013;30:226–231. PubMed

Dhanani S, Hornby L, Ward R, et al. Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study. Crit Care Med. 2014;42:2358–2369. PubMed

Sque M, Walker W, Long-Sutehall T, Morgan M, Randhawa G, Rodney A. Bereaved donor families’ experiences of organ and tissue donation, and perceived influences on their decision making. J Crit Care. 2018;45:82–89. PubMed

Dalle Ave AL, Bernat JL. Uncontrolled donation after circulatory determination of death: a systematic ethical analysis. J Intensive Care Med. 2018;33:624–634. PubMed

Joffe AR, Carcillo J, Anton N, et al. Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent. Philos Ethics Humanit Med. 2011;6:17. PubMed PMC

Rodriguez-Arias D, Tortosa JC, Burant CJ, Aubert P, Aulisio MP, Youngner SJ. One or two types of death? Attitudes of health professionals towards brain death and donation after circulatory death in three countries. Med Health Care Philos. 2013;16:457–467. PubMed

Verheijde JL, Rady MY, McGregor J. Presumed consent for organ preservation in uncontrolled donation after cardiac death in the United States: a public policy with serious consequences. Philos Ethics Humanit Med. 2009;4:15. PubMed PMC

Rodriguez-Arias D, Smith MJ, Lazar NM. Donation after circulatory death: burying the dead donor rule. Am J Bioeth. 2011;11:36–43. PubMed

Maconochie IK, Bingham R, Eich C, et al. European Resuscitation Council guidelines for resuscitation 2015: section 6. Paediatric life support. Resuscitation. 2015;95:223–248. PubMed

Oczkowski SJ, Mazzetti I, Cupido C, Fox-Robichaud AE. Family presence during resuscitation: a Canadian Critical Care Society position paper. Can Respir J. 2015;22:201–205. PubMed PMC

Barreto MDS, Peruzzo HE, Garcia-Vivar C, Marcon SS. Family presence during cardiopulmonary resuscitation and invasive procedures: a meta-synthesis. Rev Esc Enferm USP. 2019;53:e03435. PubMed

Oczkowski SJ, Mazzetti I, Cupido C, Fox-Robichaud AE. The offering of family presence during resuscitation: a systematic review and meta-analysis. J Intensive Care. 2015;3:41. PubMed PMC

Sak-Dankosky N, Andruszkiewicz P, Sherwood PR, Kvist T. Integrative review: nurses’ and physicians’ experiences and attitudes towards inpatient-witnessed resuscitation of an adult patient. J Adv Nurs. 2014;70:957–974. PubMed

Toronto CE, LaRocco SA. Family perception of and experience with family presence during cardiopulmonary resuscitation: an integrative review. J Clin Nurs. 2019;28:32–46. PubMed

Vincent C, Lederman Z. Family presence during resuscitation: extending ethical norms from paediatrics to adults. J Med Ethics. 2017;43:676–678. PubMed

Mark K. Family presence during paediatric resuscitation and invasive procedures: the parental experience: an integrative review. Scand J Caring Sci. 2021;35(1):20–36. PubMed

Timmis V. Should family members be present at resuscitation? Arch Dis Child. 2020;105:506–508. PubMed

Kenny G, Bray I, Pontin D, Jefferies R, Albarran J. A randomised controlled trial of student nurse performance of cardiopulmonary resuscitation in a simulated family-witnessed resuscitation scenario. Nurse Educ Pract. 2017;24:21–26. PubMed

Krochmal RL, Blenko JW, Afshar M, et al. Family presence at first cardiopulmonary resuscitation and subsequent limitations on care in the medical intensive care unit. Am J Crit Care. 2017;26:221–228. PubMed

Goldberger ZD, Nallamothu BK, Nichol G, et al. Policies allowing family presence during resuscitation and patterns of care during in-hospital cardiac arrest. Circ Cardiovasc Qual Outcomes. 2015;8:226–234. PubMed PMC

Tripon C, Defossez G, Ragot S, et al. Parental presence during cardiopulmonary resuscitation of children: the experience, opinions and moral positions of emergency teams in France. Arch Dis Child. 2014;99:310–315. PubMed

Nowland R, Steeg S, Quinlivan LM, et al. Management of patients with an advance decision and suicidal behaviour: a systematic review. BMJ Open. 2019;9:e023978. PubMed PMC

Weerasuriya D, Sheikh S, Morgan BW. Do-not-resuscitate orders in fatal toxic exposures: a poison center’s review. West J Emerg Med. 2012;13:294–297. PubMed PMC

Ryan CJ, Callaghan S. Legal and ethical aspects of refusing medical treatment after a suicide attempt: the Wooltorton case in the Australian context. Med J Aust. 2010;193:239–242. PubMed

Sontheimer D. Suicide by advance directive? J Med Ethics. 2008;34:e4. PubMed

Philpot SJ. Should an advance care directive refusing life-sustaining treatment be respected after an attempted suicide? Development of an algorithm to aid health care workers. J Law Med. 2019;26:557–570. PubMed

Venkat A, Drori J. When to say when: responding to a suicide attempt in the acute care setting. Narrat Inq Bioeth. 2014;4:263–270. PubMed

Terman SA. Is the principle of proportionality sufficient to guide physicians’ decisions regarding withholding/withdrawing life-sustaining treatment after suicide attempts? Am J Bioeth. 2013;13:22–24. PubMed

Brown SM, Elliott CG, Paine R. Withdrawal of nonfutile life support after attempted suicide. Am J Bioeth. 2013;13:3–12. PubMed

Song J, Guo W, Lu X, Kang X, Song Y, Gong D. The effect of bystander cardiopulmonary resuscitation on the survival of out-of-hospital cardiac arrests: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2018;26:86. PubMed PMC

Grasner JT, Wnent J, Herlitz J, et al. Survival after out-of-hospital cardiac arrest in Europe—results of the EuReCa TWO study. Resuscitation. 2020;148:218–226. PubMed

Hansen SM, Hansen CM, Folke F, et al. Bystander defibrillation for out-of-hospital cardiac arrest in public vs residential locations. JAMA Cardiol. 2017;2:507–514. PubMed PMC

Wissenberg M, Lippert FK, Folke F, et al. Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA. 2013;310:1377–1384. PubMed

Scquizzato T, Pallanch O, Belletti A, et al. Enhancing citizens response to out-of-hospital cardiac arrest: a systematic review of mobile-phone systems to alert citizens as first responders. Resuscitation. 2020;152:16–25. PubMed PMC

Tay PJM, Pek PP, Fan Q, et al. Effectiveness of a community based out-of-hospital cardiac arrest (OHCA) interventional bundle: results of a pilot study. Resuscitation. 2020;146:220–228. PubMed

Perkins GD, Olasveengen TM, Maconochie I, et al. European Resuscitation Council guidelines for resuscitation: 2017 update. Resuscitation. 2018;123:43–50. PubMed

Ro YS, Shin SD, Song KJ, et al. Public awareness and self-efficacy of cardiopulmonary resuscitation in communities and outcomes of out-of-hospital cardiac arrest: a multi-level analysis. Resuscitation. 2016;102:17–24. PubMed

Ko SY, Ro YS, Shin SD, Song KJ, Hong KJ, Kong SY. Effect of a first responder on survival outcomes after out-of-hospital cardiac arrest occurs during a period of exercise in a public place. PLoS ONE. 2018;13:e0193361. PubMed PMC

Smida T, Willson C, Salerno J, Weiss L, Salcido DD. Can you get there from here? An analysis of walkability among PulsePoint CPR alert dispatches. Resuscitation. 2020;148:135–139. PubMed

Anto-Ocrah M, Maxwell N, Cushman J, et al. Public knowledge and attitudes towards bystander cardiopulmonary resuscitation (CPR) in Ghana, West Africa. Int J Emerg Med. 2020;13:29. PubMed PMC

Matsuyama T, Scapigliati A, Pellis T, Greif R, Iwami T. Willingness to perform bystander cardiopulmonary resuscitation: a scoping review. Resusc Plus. 2020;4:100043. PubMed PMC

Brinkrolf P, Bohn A, Lukas RP, et al. Senior citizens as rescuers: Is reduced knowledge the reason for omitted lay-resuscitation-attempts? Results from a representative survey with 2004 interviews. PLoS ONE. 2017;12:e0178938. PubMed PMC

Dobbie F, MacKintosh AM, Clegg G, Stirzaker R, Bauld L. Attitudes towards bystander cardiopulmonary resuscitation: results from a cross-sectional general population survey. PLoS ONE. 2018;13:e0193391. PubMed PMC

Sasson C, Haukoos JS, Bond C, et al. Barriers and facilitators to learning and performing cardiopulmonary resuscitation in neighborhoods with low bystander cardiopulmonary resuscitation prevalence and high rates of cardiac arrest in Columbus, OH. Circ Cardiovasc Qual Outcomes. 2013;6:550–558. PubMed PMC

Cheskes L, Morrison LJ, Beaton D, Parsons J, Dainty KN. Are Canadians more willing to provide chest-compression-only cardiopulmonary resuscitation (CPR)?—A nation-wide public survey. CJEM. 2016;18:253–263. PubMed

Malta Hansen C, Rosenkranz SM, Folke F, et al. Lay bystanders’ perspectives on what facilitates cardiopulmonary resuscitation and use of automated external defibrillators in real cardiac arrests. J Am Heart Assoc. 2017;6(3):e004572. PubMed PMC

Tanigawa K, Iwami T, Nishiyama C, Nonogi H, Kawamura T. Are trained individuals more likely to perform bystander CPR? An observational study. Resuscitation. 2011;82:523–528. PubMed

Liaw SY, Chew KS, Zulkarnain A, et al. Improving perception and confidence towards bystander cardiopulmonary resuscitation and public access automated external defibrillator program: How does training program help? Int J Emerg Med. 2020;13:13. PubMed PMC

Fukushima H, Asai H, Seki T, Takano K, Bolstad F. The effect of 10-min dispatch-assisted cardiopulmonary resuscitation training: a randomized simulation pilot study. Int J Emerg Med. 2020;13:31. PubMed PMC

Olasveengen TM, Mancini ME, Perkins GD, et al. Adult basic life support: international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2020;156:A35–A79. PubMed PMC

Ringh M, Rosenqvist M, Hollenberg J, et al. Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med. 2015;372:2316–2325. PubMed

Caputo ML, Muschietti S, Burkart R, et al. Lay persons alerted by mobile application system initiate earlier cardio-pulmonary resuscitation: a comparison with SMS-based system notification. Resuscitation. 2017;114:73–78. PubMed

Berglund E, Claesson A, Nordberg P, et al. A smartphone application for dispatch of lay responders to out-of-hospital cardiac arrests. Resuscitation. 2018;126:160–165. PubMed

Hansen CM, Kragholm K, Granger CB, et al. The role of bystanders, first responders, and emergency medical service providers in timely defibrillation and related outcomes after out-of-hospital cardiac arrest: results from a statewide registry. Resuscitation. 2015;96:303–309. PubMed

Sarkisian L, Mickley H, Schakow H, et al. Global positioning system alerted volunteer first responders arrive before emergency medical services in more than four out of five emergency calls. Resuscitation. 2020;152:170–176. PubMed

Raun L, Pederson J, Campos L, Ensor K, Persse D. Effectiveness of the dual dispatch to cardiac arrest policy in Houston, Texas. J Public Health Manag Pract. 2019;25:E13–E21. PubMed

Pijls RWM, Nelemans PJ, Rahel BM, Gorgels APM. Characteristics of a novel citizen rescue system for out-of-hospital cardiac arrest in the Dutch province of Limburg: relation to incidence and survival. Neth Heart J. 2019;27:100–107. PubMed PMC

Zijlstra JA, Stieglis R, Riedijk F, Smeekes M, van der Worp WE, Koster RW. Local lay rescuers with AEDs, alerted by text messages, contribute to early defibrillation in a Dutch out-of-hospital cardiac arrest dispatch system. Resuscitation. 2014;85:1444–1449. PubMed

Stroop R, Kerner T, Strickmann B, Hensel M. Mobile phone-based alerting of CPR-trained volunteers simultaneously with the ambulance can reduce the resuscitation-free interval and improve outcome after out-of-hospital cardiac arrest: a German, population-based cohort study. Resuscitation. 2020;147:57–64. PubMed

Boland LL, Formanek MB, Harkins KK, et al. Minnesota Heart Safe Communities: Are community-based initiatives increasing pre-ambulance CPR and AED use? Resuscitation. 2017;119:33–36. PubMed

Park YM, Shin SD, Lee YJ, Song KJ, Ro YS, Ahn KO. Cardiopulmonary resuscitation by trained responders versus lay persons and outcomes of out-of-hospital cardiac arrest: a community observational study. Resuscitation. 2017;118:55–62. PubMed

Nord A, Svensson L, Karlsson T, Claesson A, Herlitz J, Nilsson L. Increased survival from out-of-hospital cardiac arrest when off duty medically educated personnel perform CPR compared with laymen. Resuscitation. 2017;120:88–94. PubMed

Dainty KN, Vaid H, Brooks SC. North American public opinion survey on the acceptability of crowdsourcing basic life support for out-of-hospital cardiac arrest with the PulsePoint mobile phone app. JMIR Mhealth Uhealth. 2017;5:e63. PubMed PMC

Brooks SC, Simmons G, Worthington H, Bobrow BJ, Morrison LJ. The PulsePoint Respond mobile device application to crowdsource basic life support for patients with out-of-hospital cardiac arrest: challenges for optimal implementation. Resuscitation. 2016;98:20–26. PubMed

Smith CM, Wilson MH, Ghorbangholi A, et al. The use of trained volunteers in the response to out-of-hospital cardiac arrest—the GoodSAM experience. Resuscitation. 2017;121:123–126. PubMed

Jaffe E, Dadon Z, Alpert EA. Wisdom of the crowd in saving lives: the Life Guardians app. Prehosp Disaster Med. 2018;33:550–552. PubMed

Barry T, Doheny MC, Masterson S, et al. Community first responders for out-of-hospital cardiac arrest in adults and children. Cochrane Database Syst Rev. 2019;7:CD012764. PubMed PMC

Krammel M, Lobmeyr E, Sulzgruber P, et al. The impact of a high-quality basic life support police-based first responder system on outcome after out-of-hospital cardiac arrest. PLoS ONE. 2020;15:e0233966. PubMed PMC

Svensson A, Elmqvist C, Fridlund B, Rask M, Andersson R, Stening K. Using firefighters as medical first responders to shorten response time in rural areas in Sweden. Aust J Rural Health. 2020;28:6–14. PubMed

Haskins B, Smith K, Cameron P, et al. The impact of bystander relation and medical training on out-of-hospital cardiac arrest outcomes. Resuscitation. 2020;150:72–79. PubMed

Sayre MR, Barnard LM, Counts CR, et al. Prevalence of COVID-19 in out-of-hospital cardiac arrest: implications for bystander cardiopulmonary resuscitation. Circulation. 2020;142:507–509. PubMed

Mausz J, Snobelen P, Tavares W. “Please. Don’t. Die.”: A grounded theory study of bystander cardiopulmonary resuscitation. Circ Cardiovasc Qual Outcomes. 2018;11:e004035. PubMed

Rosoff PM, Schneiderman LJ. Response to open peer commentaries on “irrational exuberance: cardiopulmonary resuscitation as fetish”. Am J Bioeth. 2017;17:W1–W3. PubMed

Field RA, Soar J, Nolan JP, Perkins GD. Epidemiology and outcome of cardiac arrests reported in the lay-press: an observational study. J R Soc Med. 2011;104:525–531. PubMed PMC

Mathiesen WT, Bjørshol CA, Braut GS, Soreide E. Reactions and coping strategies in lay rescuers who have provided CPR to out-of-hospital cardiac arrest victims: a qualitative study. BMJ Open. 2016;6:e010671. PubMed PMC

Zijlstra JA, Beesems SG, De Haan RJ, Koster RW. Psychological impact on dispatched local lay rescuers performing bystander cardiopulmonary resuscitation. Resuscitation. 2015;92:115–121. PubMed

Nord-Ljungquist H, Engström A, Fridlund B, Elmqvist C. Lone and lonely in a double ambivalence situation as experienced by callers while waiting for the ambulance in a rural environment. Scand J Caring Sci. 2020;34:566–574. PubMed

Schnaubelt S, Monsieurs KG, Semeraro F, et al. Clinical outcomes from out-of-hospital cardiac arrest in low-resource settings—a scoping review. Resuscitation. 2020;156:137–145. PubMed

Schwartz CE, Wheeler HB, Hammes B, et al. Early intervention in planning end-of-life care with ambulatory geriatric patients: results of a pilot trial. Arch Intern Med. 2002;162:1611–1618. PubMed

Doorenbos AZ, Levy WC, Curtis JR, Dougherty CM. An intervention to enhance goals-of-care communication between heart failure patients and heart failure providers. J Pain Symptom Manage. 2016;52:353–360. PubMed PMC

Houben CHM, Spruit MA, Luyten H, et al. Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones. Thorax. 2019;74:328–336. PubMed

Engelhardt JB, Rizzo VM, Della Penna RD, et al. Effectiveness of care coordination and health counseling in advancing illness. Am J Manag Care. 2009;15:817–825. PubMed

Briggs LA, Kirchhoff KT, Hammes BJ, Song MK, Colvin ER. Patient-centered advance care planning in special patient populations: a pilot study. J Prof Nurs. 2004;20:47–58. PubMed

Fischer SM, Cervantes L, Fink RM, Kutner JS. Apoyo con Carino: a pilot randomized controlled trial of a patient navigator intervention to improve palliative care outcomes for Latinos with serious illness. J Pain Symptom Manage. 2015;49:657–665. PubMed PMC

Perry E, Swartz J, Brown S, Smith D, Kelly G, Swartz R. Peer mentoring: a culturally sensitive approach to end-of-life planning for long-term dialysis patients. Am J Kidney Dis. 2005;46:111–119. PubMed

McCannon JB, O’Donnell WJ, Thompson BT, et al. Augmenting communication and decision making in the intensive care unit with a cardiopulmonary resuscitation video decision support tool: a temporal intervention study. J Palliat Med. 2012;15:1382–1387. PubMed PMC

Volandes AE, Ferguson LA, Davis AD, et al. Assessing end-of-life preferences for advanced dementia in rural patients using an educational video: a randomized controlled trial. J Palliat Med. 2011;14:169–177. PubMed

Epstein AS, Volandes AE, Chen LY, et al. A randomized controlled trial of a cardiopulmonary resuscitation video in advance care planning for progressive pancreas and hepatobiliary cancer patients. J Palliat Med. 2013;16:623–631. PubMed PMC

Sharma RK, Szmuilowicz E, Ogunseitan A, et al. Evaluation of a mastery learning intervention on hospitalists’ code status discussion skills. J Pain Symptom Manage. 2017;53:1066–1070. PubMed

Deep KS, Griffith CH, Wilson JF. Communication and decision making about life-sustaining treatment: examining the experiences of resident physicians and seriously-ill hospitalized patients. J Gen Intern Med. 2008;23:1877–1882. PubMed PMC

Mian P, Warchal S, Whitney S, et al. Impact of a multifaceted intervention on nurses’ and physicians’ attitudes and behaviors toward family presence during resuscitation. Crit Care Nurse. 2007;27:52–61. PubMed

Pye S, Kane J, Jones A. Parental presence during pediatric resuscitation: the use of simulation training for cardiac intensive care nurses. J Spec Pediatr Nurs. 2010;15:172–175. PubMed

Feagan LM, Fisher NJ. The impact of education on provider attitudes toward family-witnessed resuscitation. J Emerg Nurs. 2011;37:231–239. PubMed

Morrison RS, Chichin E, Carter J, Burack O, Lantz M, Meier DE. The effect of a social work intervention to enhance advance care planning documentation in the nursing home. J Am Geriatr Soc. 2005;53:290–294. PubMed

Anderson N, Slark J, Gott M. How are ambulance personnel prepared and supported to withhold or terminate resuscitation and manage patient death in the field? A scoping review. Australas J Paramed. 2019 doi: 10.33151/ajp.16.697. DOI

Whitehead L, Perkins GD, Clarey A, Haywood KL. A systematic review of the outcomes reported in cardiac arrest clinical trials: the need for a core outcome set. Resuscitation. 2015;88:150–157. PubMed

Sawyer KN, Camp-Rogers TR, Kotini-Shah P, et al. Sudden cardiac arrest survivorship: a scientific statement from the American Heart Association. Circulation. 2020;141:e654–e685. PubMed

Nolan JP, Soar J, Smith GB, et al. Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation. 2014;85:987–992. PubMed

Hawkes C, Booth S, Ji C, et al. Epidemiology and outcomes from out-of-hospital cardiac arrests in England. Resuscitation. 2017;110:133–140. PubMed

Moulaert VR, Goossens M, Heijnders IL, Verbunt JA, Heugten CM. Early neurologically focused follow-up after cardiac arrest is cost-effective: a trial-based economic evaluation. Resuscitation. 2016;106:30–36. PubMed

Gates S, Lall R, Quinn T, et al. Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation. Health Technol Assess. 2017;21:1–176. PubMed PMC

Achana F, Petrou S, Madan J, et al. Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest. Crit Care. 2020;24:579. PubMed PMC

Orioles A, Morrison WE, Rossano JW, et al. An under-recognized benefit of cardiopulmonary resuscitation: organ transplantation. Crit Care Med. 2013;41:2794–2799. PubMed

Chan PS, Krein SL, Tang F, et al. Resuscitation practices associated with survival after in-hospital cardiac arrest: a nationwide survey. JAMA Cardiol. 2016;1:189–197. PubMed PMC

Couper K, Kimani PK, Gale CP, et al. Patient, health service factors and variation in mortality following resuscitated out-of-hospital cardiac arrest in acute coronary syndrome: Analysis of the Myocardial Ischaemia National Audit Project. Resuscitation. 2018;124:49–57. PubMed

Lilford R, Mohammed MA, Spiegelhalter D, Thomson R. Use and misuse of process and outcome data in managing performance of acute medical care: avoiding institutional stigma. Lancet. 2004;363:1147–1154. PubMed

Perkins GD, Brace-McDonnell SJ. The UK Out of Hospital Cardiac Arrest Outcome (OHCAO) project. BMJ Open. 2015;5:e008736. PubMed PMC

Blewer AL, McGovern SK, Schmicker RH, et al. Gender disparities among adult recipients of bystander cardiopulmonary resuscitation in the public. Circ Cardiovasc Qual Outcomes. 2018;11:e004710. PubMed PMC

Brown TP, Booth S, Hawkes CA, et al. Characteristics of neighbourhoods with high incidence of out-of-hospital cardiac arrest and low bystander cardiopulmonary resuscitation rates in England. Eur Heart J Qual Care Clin Outcomes. 2019;5:51–62. PubMed PMC

Edelson DP, Yuen TC, Mancini ME, et al. Hospital cardiac arrest resuscitation practice in the United States: a nationally representative survey. J Hosp Med. 2014;9:353–357. PubMed PMC

Tirkkonen J, Nurmi J, Olkkola KT, Tenhunen J, Hoppu S. Cardiac arrest teams and medical emergency teams in Finland: a nationwide cross-sectional postal survey. Acta Anaesthesiol Scand. 2014;58:420–427. PubMed

Carberry J, Couper K, Yeung J. The implementation of cardiac arrest treatment recommendations in English acute NHS trusts: a national survey. Postgrad Med J. 2017;93:653–659. PubMed PMC

Soar J, Maconochie I, Wyckoff MH, et al. 2019 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2019;145:95–150. PubMed

Yeung J, Matsuyama T, Bray J, Reynolds J, Skrifvars MB. Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest?—A systematic review. Resuscitation. 2019;137:102–115. PubMed

Perkins GD, Jacobs IG, Nadkarni VM, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein resuscitation registry templates for out-of-hospital cardiac arrest: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Resuscitation. 2015;96:328–340. PubMed

Nolan JP, Berg RA, Andersen LW, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein resuscitation registry template for in-hospital cardiac arrest: a consensus report from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia) Resuscitation. 2019;144:166–177. PubMed

Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009;374:86–89. PubMed

Haywood K, Whitehead L, Nadkarni VM, et al. COSCA (core outcome set for cardiac arrest) in adults: an advisory statement from the international liaison committee on resuscitation. Resuscitation. 2018;127:147–163. PubMed

Clarke M. Standardising outcomes for clinical trials and systematic reviews. Trials. 2007;8:39. PubMed PMC

Williamson PR, Altman DG, Blazeby JM, et al. Developing core outcome sets for clinical trials: issues to consider. Trials. 2012;13:132. PubMed PMC

Tiainen M, Vaahersalo J, Skrifvars MB, Hästbacka J, Grönlund J, Pettilä V. Surviving out-of-hospital cardiac arrest: the neurological and functional outcome and health-related quality of life one year later. Resuscitation. 2018;129:19–23. PubMed

Bohm M, Lilja G, Finnbogadottir H, et al. Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest. Resuscitation. 2019;135:197–204. PubMed

Calvert M, Kyte D, Mercieca-Bebber R, et al. Guidelines for inclusion of patient-reported outcomes in clinical trial protocols: the SPIRIT-PRO extension. JAMA. 2018;319:483–494. PubMed

Andrew E, Mercier E, Nehme Z, Bernard S, Smith K. Long-term functional recovery and health-related quality of life of elderly out-of-hospital cardiac arrest survivors. Resuscitation. 2018;126:118–124. PubMed

Caro-Codón J, Rey JR, Lopez-de-Sa E, et al. Long-term neurological outcomes in out-of-hospital cardiac arrest patients treated with targeted-temperature management. Resuscitation. 2018;133:33–39. PubMed

Nehme Z, Andrew E, Bernard S, Smith K. Sex differences in the quality-of-life and functional outcome of cardiac arrest survivors. Resuscitation. 2019;137:21–28. PubMed

Grasner JT, Lefering R, Koster RW, et al. EuReCa ONE-27 Nations, ONE Europe, ONE Registry: a prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation. 2016;105:188–195. PubMed

Okubo M, Schmicker RH, Wallace DJ, et al. Variation in survival after out-of-hospital cardiac arrest between emergency medical services agencies. JAMA Cardiol. 2018;3:989–999. PubMed PMC

Kiguchi T, Okubo M, Nishiyama C, et al. Out-of-hospital cardiac arrest across the World: first report from the International Liaison Committee on Resuscitation (ILCOR) Resuscitation. 2020;152:39–49. PubMed

Mentzelopoulos SD, Mantzanas M, van Belle G, Nichol G. Evolution of European Union legislation on emergency research. Resuscitation. 2015;91:84–91. PubMed

Perkins GD, Ji C, Deakin CD, et al. A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med. 2018;379:711–721. PubMed

Mentzelopoulos SD, Bossaert L, Raffay V, et al. A survey of key opinion leaders on ethical resuscitation practices in 31 European countries. Resuscitation. 2016;100:11–17. PubMed

Perkins GD, Bossaert L, Nolan J, et al. Proposed revisions to the EU clinical trials directive—comments from the European Resuscitation Council. Resuscitation. 2013;84:263–264. PubMed

Lascarrou JB, Merdji H, Le Gouge A, et al. Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med. 2019;381:2327–2337. PubMed

CRASH Trial Management Group Research in emergency situations: with or without relatives consent. Emerg Med J. 2004;21:703. PubMed PMC

Booth MG. Informed consent in emergency research: a contradiction in terms. Sci Eng Ethics. 2007;13:351–359. PubMed

Kompanje EJ, Maas AI, Menon DK, Kesecioglu J. Medical research in emergency research in the European Union member states: tensions between theory and practice. Intensive Care Med. 2014;40:496–503. PubMed

Lecouturier J, Rodgers H, Ford GA, et al. Clinical research without consent in adults in the emergency setting: a review of patient and public views. BMC Med Ethics. 2008;9:9. PubMed PMC

Kamarainen A, Silfvast T, Saarinen S, Virta J, Virkkunen I. Conduct of emergency research in patients unable to give consent—experiences and perceptions of patients, their consent providing next of kin, and treating physicians following a prehospital resuscitation trial. Resuscitation. 2012;83:81–85. PubMed

Roberts I, Prieto-Merino D, Shakur H, Chalmers I, Nicholl J. Effect of consent rituals on mortality in emergency care research. Lancet. 2011;377:1071–1072. PubMed

Biros MH, Sargent C, Miller K. Community attitudes towards emergency research and exception from informed consent. Resuscitation. 2009;80:1382–1387. PubMed PMC

Goldstein JN, Espinola JA, Fisher J, Pallin DJ, Camargo CA. Public opinion of a stroke clinical trial using exception from informed consent. Int J Emerg Med. 2010;3:385–389. PubMed PMC

Burns KE, Magyarody NM, Duffett M, Nisenbaum R, Cook DJ. Attitudes of the general public toward alternative consent models. Am J Crit Care. 2011;20:75–83. PubMed

Silbergleit R, Biros MH, Harney D, Dickert N, Baren J. Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience. Acad Emerg Med. 2012;19:448–454. PubMed PMC

Nelson MJ, Deiorio NM, Schmidt TA, Zive DM, Griffiths D, Newgard CD. Why persons choose to opt out of an exception from informed consent cardiac arrest trial. Resuscitation. 2013;84:825–830. PubMed PMC

Dickert NW, Mah VA, Biros MH, et al. Consulting communities when patients cannot consent: a multicenter study of community consultation for research in emergency settings. Crit Care Med. 2014;42:272–280. PubMed PMC

Callaway CW. Studying community consultation in exception from informed consent trials. Crit Care Med. 2014;42:451–453. PubMed PMC

Fehr AE, Pentz RD, Dickert NW. Learning from experience: a systematic review of community consultation acceptance data. Ann Emerg Med. 2015;65:162–171.e3. PubMed

Stergiopoulos S, Michaels DL, Kunz BL, Getz KA. Measuring the impact of patient engagement and patient centricity in clinical research and development. Ther Innov Regul Sci. 2020;54:103–116. PubMed

D’Souza R, Hall C, Sermer M, Siu S, Silversides C. Development of a core outcome set for studies on cardiac disease in pregnancy (COSCarP): a study protocol. Trials. 2020;21:300. PubMed PMC

Ingoe HMA, Eardley W, Rangan A, Hewitt C, McDaid C. An international multi-stakeholder delphi consensus exercise to develop a core outcomes set (COS) for surgical fixation of rib fractures. Injury. 2020;51:224–229. PubMed

Webbe JWH, Duffy JMN, Afonso E, et al. Core outcomes in neonatology: development of a core outcome set for neonatal research. Arch Dis Child Fetal Neonatal Ed. 2020;105:425–431. PubMed PMC

Vat LE, Finlay T, Schuitmaker-Warnaar TJ, et al. Evaluating the “return on patient engagement initiatives” in medicines research and development: a literature review. Health Expect. 2020;23:5–18. PubMed PMC

Koffman J, Yorganci E, Murtagh F, et al. The AMBER care bundle for hospital inpatients with uncertain recovery nearing the end of life: the ImproveCare feasibility cluster RCT. Health Technol Assess. 2019;23:1–150. PubMed PMC

Ngaage D, Mitchell N, Dean A, et al. Feasibility study of early outpatient review and early cardiac rehabilitation after cardiac surgery: mixed-methods research design—a study protocol. BMJ Open. 2019;9:e035787. PubMed PMC

Rapport F, Auton E, Warren C, Braithwaite J. Addressing clinical equipoise for hearing devices: the qualitative COACH (q-COACH) study protocol for Australian stakeholder involvement in the design of a randomised controlled trial. BMJ Open. 2019;9:e030100. PubMed PMC

Lewis RK. Mental health strategies for prevention and intervention: community perspectives. J Prev Interv Community. 2019 doi: 10.1080/10852352.2019.1654261. PubMed DOI

Sanders AB, Hiller K, Duldner J. Researchers’ understanding of the federal guidelines for waiver of and exception from informed consent. Acad Emerg Med. 2005;12:1045–1049. PubMed

Kowey P, Ornato J. Resuscitation research and emergency waiver of informed consent. Resuscitation. 2000;47:307–310. PubMed

Sayre MR, White LJ, Brown LH, McHenry SD, National EMS Research Agenda Writing Team The National EMS Research Agenda executive summary. Emergency medical services. Ann Emerg Med. 2002;40:636–643. PubMed

Hsieh M, Dailey MW, Callaway CW. Surrogate consent by family members for out-of-hospital cardiac arrest research. Acad Emerg Med. 2001;8:851–853. PubMed

McClure KB, DeIorio NM, Gunnels MD, Ochsner MJ, Biros MH, Schmidt TA. Attitudes of emergency department patients and visitors regarding emergency exception from informed consent in resuscitation research, community consultation, and public notification. Acad Emerg Med. 2003;10:352–359. PubMed

Nichol G, Steen P, Herlitz J, et al. International Resuscitation Network Registry: design, rationale and preliminary results. Resuscitation. 2005;65:265–277. PubMed

Hartmann M, Hartmann-Vareilles F. The clinical trials directive: How is it affecting Europe’s noncommercial research? PLoS Clin Trials. 2006;1:e13. PubMed PMC

McMahon AD, Conway DI, Macdonald TM, McInnes GT. The unintended consequences of clinical trials regulations. PLoS Med. 2009;3:e1000131. PubMed PMC

Bosch X. Europe’s restrictive rules strangling clinical research. Nat Med. 2005;11:1260. PubMed

Liddell K, Kompanje EJ, Lemaire F, et al. Recommendations in relation to the EU clinical trials directive and medical research involving incapacitated adults. Wien Klin Wochenschr. 2006;118:183–191. PubMed

Tolle SW, Teno JM. Lessons from Oregon in embracing complexity in end-of-life care. N Engl J Med. 2017;376:1078–1082. PubMed

Grasner JT, Masterson S. EuReCa and international resuscitation registries. Curr Opin Crit Care. 2015;21:215–219. PubMed

Girotra S, Nallamothu BK, Spertus JA, et al. Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2012;367:1912–1920. PubMed PMC

Merchant RM, Berg RA, Yang L, et al. Hospital variation in survival after in-hospital cardiac arrest. J Am Heart Assoc. 2014;3:e000400. PubMed PMC

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012;307:1161–1168. PubMed

Nakahara S, Tomio J, Takahashi H, et al. Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study. BMJ. 2013;347:f6829. PubMed PMC

Donnino MW, Salciccioli JD, Howell MD, et al. Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry. BMJ. 2014;348:g3028. PubMed PMC

Bak MAR, Blom MT, Tan HL, Willems DL. Ethical aspects of sudden cardiac arrest research using observational data: a narrative review. Crit Care. 2018;22:212. PubMed PMC

Mumma BE, Diercks DB, Danielsen B, Holmes JF. Probabilistic linkage of prehospital and outcomes data in out-of-hospital cardiac arrest. Prehosp Emerg Care. 2015;19:358–364. PubMed PMC

Priori SG. Genetic testing to predict sudden cardiac death: current perspectives and future goals. Indian Heart J. 2014;66(Suppl 1):S58–S60. PubMed PMC

Docherty AB, Lone NI. Exploiting big data for critical care research. Curr Opin Crit Care. 2015;21:467–472. PubMed

Pullman D, Hodgkinson K. Genetic knowledge and moral responsibility: ambiguity at the interface of genetic research and clinical practice. Clin Genet. 2006;69:199–203. PubMed

Badcock D, Kelly AM, Kerr D, Reade T. The quality of medical record review studies in the international emergency medicine literature. Ann Emerg Med. 2005;45:444–447. PubMed

Kaji AH, Schriger D, Green S. Looking through the retrospectoscope: reducing bias in emergency medicine chart review studies. Ann Emerg Med. 2014;64:292–298. PubMed

Nishiyama C, Brown SP, May S, et al. Apples to apples or apples to oranges? International variation in reporting of process and outcome of care for out-of-hospital cardiac arrest. Resuscitation. 2014;85:1599–1609. PubMed PMC

Manrai AK, Funke BH, Rehm HL, et al. Genetic misdiagnoses and the potential for health disparities. N Engl J Med. 2016;375:655–665. PubMed PMC

Tu JV, Willison DJ, Silver FL, et al. Impracticability of informed consent in the Registry of the Canadian Stroke Network. N Engl J Med. 2004;350:1414–1421. PubMed

Freeman BD, Bolcic-Jankovic D, Kennedy CR, et al. Perspectives of decisional surrogates and patients regarding critical illness genetic research. AJOB Empir Bioeth. 2016;7:39–47. PubMed PMC

Offerman SR, Nishijima DK, Ballard DW, Chetipally UK, Vinson DR, Holmes JF. The use of delayed telephone informed consent for observational emergency medicine research is ethical and effective. Acad Emerg Med. 2013;20:403–407. PubMed PMC

Fox EE, Bulger EM, Dickerson AS, et al. Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience. J Trauma Acute Care Surg. 2013;75:S3–S8. PubMed PMC

Fang J, Kapral MK, Richards J, Robertson A, Stamplecoski M, Silver FL. The Registry of Canadian Stroke Network: an evolving methodology. Acta Neurol Taiwan. 2011;20:77–84. PubMed

Thorogood A, Zawati MH. International guidelines for privacy in genomic biobanking (or the unexpected virtue of pluralism) J Law Med Ethics. 2015;43:690–702. PubMed

Auffray C, Balling R, Barroso I, et al. Making sense of big data in health research: towards an EU action plan. Genome Med. 2016;8:71. PubMed PMC

Bodenheimer T. Uneasy alliance—clinical investigators and the pharmaceutical industry. N Engl J Med. 2000;342:1539–1544. PubMed

Moorthy VS, Karam G, Vannice KS, Kieny MP. Rationale for WHO’s new position calling for prompt reporting and public disclosure of interventional clinical trial results. PLoS Med. 2015;12:e1001819. PubMed PMC

Kiley R, Peatfield T, Hansen J, Reddington F. Data sharing from clinical trials—a research funder’s perspective. N Engl J Med. 2017;377:1990–1992. PubMed

Ornato JP, Becker LB, Weisfeldt ML, Wright BA. Cardiac arrest and resuscitation: an opportunity to align research prioritization and public health need. Circulation. 2010;122:1876–1879. PubMed

Kudenchuk PJ, Brown SP, Daya M, et al. Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest. N Engl J Med. 2016;374:1711–1722. PubMed

Tierney WM, Meslin EM, Kroenke K. Industry support of medical research: important opportunity or treacherous pitfall? J Gen Intern Med. 2016;31:228–233. PubMed PMC

Ong MEH, Perkins GD, Cariou A. Out-of-hospital cardiac arrest: prehospital management. Lancet. 2018;391:980–988. PubMed

Chan PS, Berg RA, Nadkarni VM. Code blue during the COVID-19 pandemic. Circ Cardiovasc Qual Outcomes. 2020;13:e006779. PubMed PMC

Kramer DB, Lo B, Dickert NW. CPR in the Covid-19 era—an ethical framework. N Engl J Med. 2020;383:e6. PubMed

Mahase E, Kmietowicz Z. Covid-19: doctors are told not to perform CPR on patients in cardiac arrest. BMJ. 2020;368:m1282. PubMed

Shao F, Xu S, Ma X, et al. In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China. Resuscitation. 2020;151:18–23. PubMed PMC

Baldi E, Sechi GM, Mare C, et al. Out-of-hospital cardiac arrest during the Covid-19 outbreak in Italy. N Engl J Med. 2020;383:496–498. PubMed PMC

Van de Voorde P, Bossaert L, Mentzelopoulos S, et al. Ethics of resuscitation and end-of-life decisions. Notfall Rettungsmed. 2020;23:263–267. PubMed PMC

Docherty AB, Harrison EM, Green CA, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020;369:m1985. PubMed PMC

Grasselli G, Pesenti A, Cecconi M. Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response. JAMA. 2020;323:1545–1546. PubMed

Kandori K, Narumiya H, Iizuka R. Extracorporeal cardiopulmonary resuscitation should not be performed on confirmed or suspected COVID-19 patients. Resuscitation. 2020;153:6–7. PubMed PMC

Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med. 2000;342:1887–1892. PubMed PMC

Barnish MS, Turner S. The value of pragmatic and observational studies in health care and public health. Pragmat Obs Res. 2017;8:49–55. PubMed PMC

Howes C. Caring until the end: a systematic literature review exploring paediatric intensive care unit end-of-life care. Nurs Crit Care. 2015;20:41–51. PubMed

Michalsen A, Long AC, DeKeyser Ganz F, et al. Interprofessional shared decision-making in the ICU: a systematic review and recommendations from an expert panel. Crit Care Med. 2019;47:1258–1266. PubMed

Hawkes CA, Fritz Z, Deas G, et al. Development of the recommended summary plan for emergency care and treatment (ReSPECT) Resuscitation. 2020;148:98–107. PubMed

Taylor J, Booth A, Beresford B, Phillips B, Wright K, Fraser L. Specialist paediatric palliative care for children and young people with cancer: a mixed-methods systematic review. Palliat Med. 2020;34:731–775. PubMed PMC

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