Antimicrobial nanofibrous mats with controllable drug release produced from hydrophobized hyaluronan
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
34119178
DOI
10.1016/j.carbpol.2021.118225
PII: S0144-8617(21)00612-3
Knihovny.cz E-resources
- Keywords
- Electrospinning, Lauroyl hyaluronan, Nanofiber, Octenidine, Triclosan,
- MeSH
- Anti-Bacterial Agents chemistry pharmacology toxicity MeSH
- 3T3 Cells MeSH
- Hydrophobic and Hydrophilic Interactions MeSH
- Imines chemistry pharmacology toxicity MeSH
- Hyaluronic Acid chemistry pharmacology toxicity MeSH
- Delayed-Action Preparations chemistry pharmacology toxicity MeSH
- Microbial Sensitivity Tests MeSH
- Mice MeSH
- Nanofibers chemistry toxicity MeSH
- Drug Carriers chemistry pharmacology toxicity MeSH
- Pseudomonas aeruginosa drug effects MeSH
- Pyridines chemistry pharmacology toxicity MeSH
- Staphylococcus aureus drug effects MeSH
- Triclosan chemistry pharmacology toxicity MeSH
- Drug Liberation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Imines MeSH
- Hyaluronic Acid MeSH
- Delayed-Action Preparations MeSH
- Drug Carriers MeSH
- octenidine MeSH Browser
- Pyridines MeSH
- Triclosan MeSH
Due to their large active surface, high loading efficiency, and tunable dissolution profiles, nanofibrous mats are often cited as promising drug carriers or antimicrobial membranes. Hyaluronic acid has outstanding biocompatibility, but it is hydrophilic. Nanofibrous structures made from hyaluronan dissolve immediately, making them unsuitable for controlled drug release and longer applications. We aimed to prepare a hyaluronan-based antimicrobial nanofibrous material, which would retain its integrity in aqueous environments. Self-supporting nanofibrous mats containing octenidine dihydrochloride or triclosan were produced by electrospinning from hydrophobized hyaluronan modified with a symmetric lauric acid anhydride. The nanofibrous mats required no cross-linking to be stable in PBS for 7 days. The encapsulation efficiency of antiseptics was nearly 100%. Minimal release of octenidine was observed, while up to 30% of triclosan was gradually released in 72 h. The nanofibrous materials exhibited antimicrobial activity, the fibroblast viability was directly dependent on the antiseptic content and its release.
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