Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discoveries pointing to mitochondria as organelles affecting a number of other auxiliary processes. They go beyond the classical energy provision via acting as a relay point of many catabolic and anabolic processes, to signaling pathways critically affecting cell growth by their implication in de novo pyrimidine synthesis. These additional roles further underscore the importance of mitochondrial homeostasis in various tissues, where its deregulation promotes a number of pathologies. While it has long been known that mitochondria can move within a cell to sites where they are needed, recent research has uncovered that mitochondria can also move between cells. While this intriguing field of research is only emerging, it is clear that mobilization of mitochondria requires a complex apparatus that critically involves mitochondrial proteins of the Miro family, whose role goes beyond the mitochondrial transfer, as will be covered in this review.

Faculty of Science Charles University Prague Czech Republic

Institute of Biotechnology Czech Academy of Sciences Prague West Czech Republic

School of Medical Science Griffith University Southport Australia

References provided by Crossref.org

Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

Miro proteins and their role in mitochondrial transfer in cancer and beyond

Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy