Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.

Department of Biological Sciences School of Medical and Life Sciences Sunway University Jalan Bandar Sunway 47500 Selangor Darul Ehsan Malaysia

Department of Medical Sciences School of Medical and Life Sciences Sunway University Jalan Universiti Bandar Sunway 47500 Selangor Darul Ehsan Malaysia

Malaysia Japan International Institute of Technology Universiti Teknologi Malaysia Jalan Sultan Yahya Petra 54100 Kuala Lumpur Malaysia

Malaysia Japan International Institute of Technology Universiti Teknologi Malaysia Jalan Sultan Yahya Petra 54100 Kuala Lumpur Malaysia; Faculty of Science Department of Chemistry University of Hradec Kralove Hradec Kralove Czech Republic

Citace poskytuje Crossref.org

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature