5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
34560940
DOI
10.1016/j.carbpol.2021.118523
PII: S0144-8617(21)00910-3
Knihovny.cz E-resources
- Keywords
- 5-Fluorouracil, Cellulose, Co-culture, Colorectal cancer, Composites, Drug carrier system, Fe(3)O(4)-nanoparticles, Microfluidic,
- MeSH
- HT29 Cells MeSH
- Cellulose chemistry MeSH
- Fluorouracil chemistry pharmacology MeSH
- HCT116 Cells MeSH
- Colorectal Neoplasms drug therapy metabolism MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Magnetic Phenomena MeSH
- Magnetic Iron Oxide Nanoparticles chemistry MeSH
- Microscopy, Electron, Scanning methods MeSH
- Nanocomposites chemistry MeSH
- Drug Carriers chemistry MeSH
- Polymers chemistry MeSH
- Antineoplastic Agents pharmacology MeSH
- Drug Liberation MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cellulose MeSH
- Fluorouracil MeSH
- Drug Carriers MeSH
- Polymers MeSH
- Antineoplastic Agents MeSH
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.
References provided by Crossref.org
