BACKGROUND: The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated instrument for assessing quality of life (QoL) in patients with severe aortic stenosis (AS). In this study, we evaluated health status outcomes, based on the TASQ, in patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). METHODS: The TASQ registry was a prospective observational registry. Patients with severe AS from nine centres in Europe and one in Canada underwent either SAVR or transfemoral TAVR. Patients completed the TASQ, Kansas City Cardiomyopathy Questionnaire and Short Form-12 V.2 prior to the intervention, predischarge, and at 30-day and 3-month follow-ups. Primary end point was the TASQ score. RESULTS: In both the TAVR (n=137) and SAVR (n=137) cohorts, significant increases were observed in all three scores. The overall TASQ score improved as did all but one of the individual domains at 3 months after the intervention (p<0.001). TASQ health expectations were the only domain which worsened (p<0.001). Across TASQ subscores, significant changes were evident from the time of discharge in the TAVR and 30-day follow-up in the SAVR cohort. In a categorical analysis of the TASQ, 39.7% of the TAVR group and 35.0% of the SAVR group had a substantially improved health status at 3 months compared with baseline. CONCLUSIONS: The TASQ captured changes in QoL among patients with severe AS who were treated with TAVR or SAVR. QoL improved substantially after either intervention, as indicated by changes in the TASQ overall score at 3 months. TRIAL REGISTRATION NUMBER: NCT03186339.

Clinical Studies and Registries Institute for Pharmacology and Preventive Medicine Cloppenburg Germany

Department of Cardiac Surgery Innsbruck Medical University Innsbruck Austria

Department of Cardiology Barts Heart Centre St Bartholomew's Hospital London UK

Department of Cardiology Bichat Claude Bernard Hospital Paris France

Department of Cardiology Department of Cardiovascular Surgery Hospital Juan Canalejo Coruna Spain

Department of Cardiology Hospital Vall d'Hebron CIBER CV Barcelona Spain

Department of Internal Medicine 3 Kiel Germany

Department of Psychiatry University Health Network Toronto Ontario Canada

Department of Structural Interventional Cardiology Department of Cardiac Surgery Careggi University Hospital Florence Italy

Department of Thoracic and Cardiovascular Surgery Hopital Prive Jacques Cartier Massy France

Division of Cardiology Department of Medicine University of Verona Verona Italy

Institut Jacques Cartier Massy France

Medical Affairs Edwards Lifesciences Nyon Switzerland

Medical Affairs Edwards Lifesciences Prague Czech Republic

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Quality of Life Measures in Aortic Stenosis Research: A Narrative Review

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NCT03186339