BACKGROUND: Elderly patients with aortic stenosis (AS) not only have a reduced life expectancy but also a reduced quality of life (QoL). The benefits of an AS intervention may be considered a balance between a good QoL and a reasonably extended life. However, the different questionnaires being used to determine the QoL were generally not developed for the specific situation of patients with AS and come with strengths and considerable weaknesses. The objective of this article was to provide an overview of the available QoL instruments in AS research, describe their strengths and weaknesses, and provide our assessment of the utility of the available scoring instruments for QoL measurements in AS. SUMMARY: We identified and reviewed the following instruments that are used in AS research: Short Form Health Survey (SF-36/SF-12), EuroQol-5D (EQ-5D), the Illness Intrusiveness Rating Scale (IIRS), the HeartQoL, the Kansas City Cardiomyopathy Questionnaire (KCCQ), the Minnesota Living with Heart Failure Questionnaire (MLHF), the MacNew Questionnaire, and the Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ). KEY MESSAGES: There is no standardized assessment of QoL in patients with AS. Many different questionnaires are being used, but they are rarely specific for AS. There is a need for AS-specific research into the QoL of patients as life prolongation may compete for an improved QoL in this elderly patient group.

Department of Cardiac Surgery Innsbruck Medical University Innsbruck Austria

Department of Cardiology Barts Heart Centre St Bartholomew's Hospital London UK

Department of Cardiology St Antonius Hospital Nieuwegein The Netherlands

Department of Cardiology University Heart Center University Hospital Zurich Zurich Switzerland

Department of Internal Medicine 3 Partner site Hamburg Kiel Lübeck Kiel Germany

Department of Psychiatry University Health Network Toronto Ontario Canada

Department of Thoracic and Cardiovascular Surgery Department of Interventional Cardiology Hôpital Privé Jacques Cartier Massy France

Edwards Lifesciences Prague Czechia

Institute for Pharmacology and Preventive Medicine Cloppenburg Germany

Interventional Cardiology The Heart Center Rigshospitalet Copenhagen Denmark

Structural Interventional Cardiology Department of Clinical and Experimental Medicine Careggi University Hospital Florence Italy

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