BACKGROUND: Building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet) was proposed to strengthen the European One Health antimicrobial resistance (AMR) surveillance approach. OBJECTIVES: To define the combinations of animal species/production types/age categories/bacterial species/specimens/antimicrobials to be monitored in EARS-Vet. METHODS: The EARS-Vet scope was defined by consensus between 26 European experts. Decisions were guided by a survey of the combinations that are relevant and feasible to monitor in diseased animals in 13 European countries (bottom-up approach). Experts also considered the One Health approach and the need for EARS-Vet to complement existing European AMR monitoring systems coordinated by the ECDC and the European Food Safety Authority (EFSA). RESULTS: EARS-Vet plans to monitor AMR in six animal species [cattle, swine, chickens (broilers and laying hens), turkeys, cats and dogs], for 11 bacterial species (Escherichia coli, Klebsiella pneumoniae, Mannheimia haemolytica, Pasteurella multocida, Actinobacillus pleuropneumoniae, Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus hyicus, Streptococcus uberis, Streptococcus dysgalactiae and Streptococcus suis). Relevant antimicrobials for their treatment were selected (e.g. tetracyclines) and complemented with antimicrobials of more specific public health interest (e.g. carbapenems). Molecular data detecting the presence of ESBLs, AmpC cephalosporinases and methicillin resistance shall be collected too. CONCLUSIONS: A preliminary EARS-Vet scope was defined, with the potential to fill important AMR monitoring gaps in the animal sector in Europe. It should be reviewed and expanded as the epidemiology of AMR changes, more countries participate and national monitoring capacities improve.

Agencia Española del Medicamento y Productos Sanitarios calle Campezo 1 EDF 8 28022 Madrid España

Antimicrobial Consumption and Resistance in Animals AMCRA Galileelaan 5 02 1210 Brussels Belgium

Department of Agriculture Food and the Marine Laboratories Backweston Celbridge Co Kildare W23 VW2C Ireland

Direction générale de l'alimentation Bureau de la santé animale 75015 Paris France

Federal Office of Consumer Protection and Food Safety Mauerstrasse 39 42 10117 Berlin Germany

Institute for State Control of Veterinary Biologicals and Medicines Hudcova 56 A Brno The Czech Republic

Istituto Superiore di Sanità Center for Gender Specific Medicine Viale Regina Elena 299 00161 Rome Italy

Laboratory of Economics of Animal Production Faculty of Veterinary Medicine Aristotle University of Thessaloniki 54124 Greece

Limerick Regional Veterinary Laboratory Department of Agriculture Food and the Marine Knockalisheen Limerick V94 WK44 Ireland

Ministry of Rural Development and Food 2 Acharnon St Athens Greece

National Veterinary Institute Department of Animal Health and Antimicrobial Strategies Ulls väg 2B SE 751 89 Uppsala Sweden

Norwegian Veterinary Institute Pb 64 N 1431 Ås Norway

Royal GD Arnsbergstraat 7 7418 EZ Deventer The Netherlands

Sciensano Veterinary Epidemiology Unit Belgian Research Centre for Health Rue Juliette Wytsmanstraat 14 1050 Brussels Belgium

University of Copenhagen Department of Veterinary and Animal Sciences Stigbøjlen 4 1870 Frederiksberg C Denmark

University of Helsinki Department of Equine and Small Animal Medicine Viikintie 49 00790 Helsinki Finland

University of Lyon French Agency for Food Environmental and Occupational Health and Safety Laboratory of Lyon Antibiotic Resistance and Bacterial Virulence Unit 31 Avenue Tony Garnier 69007 Lyon France

University of Lyon French Agency for Food Environmental and Occupational Health and Safety Laboratory of Lyon Epidemiology and Support to Surveillance Unit 31 avenue Tony Garnier 69007 Lyon France

University of West Attica Department of Public Health Policy School of Public Health Athens Greece

Utrecht University Faculty of Veterinary Medicine Department of Biomolecular Health Sciences Yalelaan 1 3584 CL Utrecht The Netherlands

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