Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer's disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD (n = 31), and cognitively normal (CN) older adults (n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum.

Department of Clinical Psychology Motol University Hospital Prague Czech Republic

Department of Neurology and Centre of Clinical Neuroscience Neuropsychology Laboratory Charles University 1st Faculty of Medicine and General University Hospital Prague Czech Republic

Department of Psychiatry University of California San Diego La Jolla CA USA

International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic

Memory Clinic Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic

Sam and Rose Stein Institute for Research on Aging University of California San Diego La Jolla CA USA

School of Aging Studies University of South Florida Tampa FL USA

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