Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
35074562
DOI
10.1016/j.etap.2022.103818
PII: S1382-6689(22)00011-4
Knihovny.cz E-resources
- Keywords
- Aquatic pollutants, Fish hematological profile, Fish immune response, Oxidative stress, SSRI,
- MeSH
- Antidepressive Agents, Second-Generation toxicity MeSH
- Water Pollutants, Chemical toxicity MeSH
- Fluoxetine toxicity MeSH
- Immunity drug effects MeSH
- Food Contamination MeSH
- Blood Cell Count MeSH
- Animal Feed MeSH
- Oncorhynchus mykiss blood immunology MeSH
- Oxidative Stress drug effects MeSH
- Kidney Tubules, Proximal drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antidepressive Agents, Second-Generation MeSH
- Water Pollutants, Chemical MeSH
- Fluoxetine MeSH
The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
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