Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
35305614
PubMed Central
PMC8933959
DOI
10.1186/s12903-022-02115-3
PII: 10.1186/s12903-022-02115-3
Knihovny.cz E-zdroje
- Klíčová slova
- Angiotensin I converting enzyme, Haplotype, Polymorphism, Recurrent aphthous stomatitis, Sex difference,
- MeSH
- aftózní stomatitida * epidemiologie genetika MeSH
- angiotensin konvertující enzym * genetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- ACE protein, human MeSH Prohlížeč
- angiotensin konvertující enzym * MeSH
BACKGROUND: Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. METHODS: The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. RESULTS: The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (Pcorr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, Pcorr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, Pcorr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, Pcorr > 0.05). CONCLUSIONS: Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.
Zobrazit více v PubMed
Queiroz SIML, da Silva MVA, de Medeiros AMC, de Oliveira PT, de Gurgel BCV, da Silveira ÉJD, et al. Recurrent aphthous ulceration: An epidemiological study of etiological factors, treatment and differential diagnosis. An Bras Dermatol. 2018;93(3):341–346. doi: 10.1590/abd1806-4841.20186228. PubMed DOI PMC
Ślebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp (Warsz) 2014;62(3):205–215. doi: 10.1007/s00005-013-0261-y. PubMed DOI PMC
Ślebioda Z, Szponar E, Kowalska A. Recurrent aphthous stomatitis: genetic aspects of etiology. Postepy Dermatol Alergol. 2013;30(2):96–102. doi: 10.5114/pdia.2013.34158. PubMed DOI PMC
Natah SS, Konttinen YT, Enattah NS, Ashammakhi N, Sharkey KA, Häyrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Surg. 2004;33(3):221–234. doi: 10.1006/ijom.2002.0446. PubMed DOI
Ceconi C, Francolini G, Olivares A, Comini L, Bachetti T, Ferrari R. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007;577(1):1–6. doi: 10.1016/j.ejphar.2007.07.061. PubMed DOI
Mendoza-Pinto C, García-Carrasco M, Jiménez-Hernández M, Jiménez Hernández C, Riebeling-Navarro C, Nava Zavala A, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010;9(4):241–245. doi: 10.1016/j.autrev.2009.10.005. PubMed DOI
Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Investig. 1990;86(4):1343–1346. doi: 10.1172/JCI114844. PubMed DOI PMC
Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JCM. ACE polymorphisms. Circ Res. 2006;98(9):1123–1133. doi: 10.1161/01.RES.0000223145.74217.e7. PubMed DOI
Keavney B, McKenzie CA, Connell JMC, Julier C, Ratcliffe PJ, Sobel E, et al. Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum Mol Genet. 1998;7(11):1745–1751. doi: 10.1093/hmg/7.11.1745. PubMed DOI
Turgut S, Turgut G, Atalay EÖ, Atalay A. Angiotensin-converting enzyme I/D polymorphism in Behçet’s disease. Med Princ Pract. 2005;14(4):213–216. doi: 10.1159/000085737. PubMed DOI
Yigit S, Tural S, Rüstemoglu A, Inanir A, Gul U, Kalkan G, et al. DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population. Mol Biol Rep. 2013;40(1):365–368. doi: 10.1007/s11033-010-0284-y. PubMed DOI
Karakus N, Yigit S, Kalkan G, Sezer S. High association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with recurrent aphthous stomatitis. Arch Dermatol Res. 2013;305(6):513–517. doi: 10.1007/s00403-013-1333-x. PubMed DOI
Ship JA, Chavez EM, Doerr PA, Henson BS, Sarmadi M. Recurrent aphthous stomatitis (Berlin, Germany: 1985) Quintessence Int. 2000;31(2):95–112. PubMed
Staalsø JM, Nielsen M, Edsen T, Koefoed P, Springborg JB, Moltke FB, et al. Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study. J Neurosurg Anesthesiol. 2011;23(4):304–309. doi: 10.1097/ANA.0b013e318225c979. PubMed DOI
Domingues-Montanari S, Hernandez-Guillamon M, Fernandez-Cadenas I, Mendioroz M, Boada M, Munuera J, et al. ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy. Neurobiol Aging. 2011;32(3):551.e13–551.e22. doi: 10.1016/j.neurobiolaging.2010.01.019. PubMed DOI
Ancelin ML, Carrière I, Scali J, Ritchie K, Chaudieu I, Ryan J. Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression. Transl Psychiatry. 2013;3(11):e322–e322. doi: 10.1038/tp.2013.95. PubMed DOI PMC
Dou XM, Cheng HJ, Meng L, Zhou LL, Ke YH, Liu LP, Li YM. Correlations between ACE single nucleotide polymorphisms and prognosis of patients with septic shock. Biosci Rep. 2017;37(2):BSR20170145. doi: 10.1042/BSR20170145. PubMed DOI PMC
Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry. 2006;11(11):1003–1015. doi: 10.1038/tp.2013.95. PubMed DOI
Wang HK, Fung HC, Hsu WC, Wu YR, Lin JC, Ro LS, et al. Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer’s disease and vascular dementia. J Neural Transm (Vienna) 2006;113(10):1499–1509. doi: 10.1007/s00702-005-0424-z. PubMed DOI
Gassó P, Mas S, Álvarez S, Ortiz J, Sotoca JM, Francino A, et al. A common variant of the ABO gene protects against hypertension in a Spanish population. Hypertens Res. 2012;35(6):592–596. doi: 10.1038/hr2001.218. PubMed DOI
Ji L, Cai X, Zhang L, Fei L, Wang L, Su J, et al. Association between polymorphisms in the renin–angiotensin–aldosterone system genes and essential hypertension in the Han Chinese Population. PLoS ONE. 2013;8(8):e72701. doi: 10.1371/journal.pone.0072701. PubMed DOI PMC
Koch W, Latz W, Eichinger M, Ganser C, Schömig A, Kastrati A. Genotyping of the angiotensin I-converting enzyme gene insertion/deletion polymorphism by the TaqMan method. Clin Chem. 2005;51(8):1547–1549. doi: 10.1373/clinchem.2005.051656. PubMed DOI
Borilova Linhartova P, Kastovsky J, Bartosova M, Musilova K, Zackova L, Kukletova M, Kukla L, Holla LI. ACE insertion/deletion polymorphism associated with caries in permanent but not primary dentition in Czech children. Caries Res. 2016;50(2):89–96. doi: 10.1159/000443534. PubMed DOI
Kowalska A, Ślebioda Z, Woźniak T, Zasadziński R, Daszkowska M, Dorocka-Bobkowska B. Beta-defensin 1 gene polymorphisms at 5′untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis. Arch Oral Biol. 2019;101:130–134. doi: 10.1016/j.archoralbio.2019.03.016. PubMed DOI
Vasku A, Soucek M, Znojil V, Rihacek I, Tschöplova S, Strelcova L, Cidl K, Blazkova M, Hajek D, Holla L, Vacha J. Angiotensin I-converting enzyme and angiotensinogem gene interaction and prediction of essential hypertension. Kidney Int. 1998;53(6):1479–1482. doi: 10.1046/j.1523-1755.1998.00924.x. PubMed DOI
Vasku A, Soucek M, Hajek D, Holla L, Znojil V, Vacha J. Association analysis of 24-blood pressure records with I/D ACE gene polymorphism and ABO blood group system. Physiol Res. 1999;48(2):99–104. PubMed
Holla L, Vasku A, Znojil V, Siskova L, Vacha J. Association of 3 gene polymorphisms with atopic diseases. J Allergy Clin Immunol. 1999;103(4):702–708. doi: 10.1016/s0091-6749(99)70246-0. PubMed DOI
Izakovicova Holla L, Fassmann A, Vasku A, Znojil V, Vanek J, Vacha J. Interaction of lymphotoxin α (TNF-β), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. J Periodontol. 2001;72(1):85–89. doi: 10.1902/jop.2001.72.1.85. PubMed DOI
McGrath DS, Foley PJ, Petrek M, Izakovicova-Holla L, Kolek V, Veeraraghavan S, Lympany PA, Pantelidis P, Vasku A, Wells AU, Welsh KI, Du Bois RM. ACE gene I/D polymorphism and sarcoidosis pulmonary disease severity. Am J Respir Crit Care Med. 2001;164(2):197–201. doi: 10.1164/ajrccm.164.2.2011009. PubMed DOI
Dursun A, Durakbasi-Dursun HG, Dursun R, Baris S, Akduman L. Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet’s disease with or without ocular involvement. Inflamm Res. 2009;58(7):401–405. doi: 10.1007/s00011-009-0005-y. PubMed DOI
Oztürk MA, Calgüneri M, Kiraz S, Ertenli I, Onat AM, Ureten K, et al. Angiotensin-converting enzyme gene polymorphism in Behçet’s disease. Clin Rheumatol. 2004;23(2):142–146. doi: 10.1007/s10067-003-0853-8. PubMed DOI
Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J. 1993;290(1):33–40. doi: 10.1042/bj2900033. PubMed DOI PMC
Petrov V, Fagard R, Lijnen P. Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes. Am J Hypertens. 2000;13(5):535–539. doi: 10.1016/s0895-7061(99)00236-8. PubMed DOI
Ozyurt K, Çelik A, Sayarlıoglu M, Colgecen E, Incı R, Karakas T, Kelles M, Cetin GY. Serum Th1, Th2 and Th17 cytokine profiles and alpha-enolase levels in recurrent aphthous stomatitis. J Oral Pathol Med. 2014;43(9):691–695. doi: 10.1111/jop.12182. PubMed DOI
Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J. Inflammation and angiotensin II. Int J Biochem Cell Biol. 2003;35(6):881–900. doi: 10.1016/S1357-2725(02)00271-6. PubMed DOI
Gandhi Sanjay K, Gainer J, King D, Brown NJ. Gender affects renal vasoconstrictor response to Ang I and Ang II. Hypertension. 1998;31(1):90–96. doi: 10.1161/01.HYP.31.1.90. PubMed DOI
Bachmann J, Feldmer M, Ganten U, Stock G, Ganten D. Sexual dimorphism of blood pressure: possible role of the renin–angiotensin system. J Steroid Biochem Mol Biol. 1991;40(4):511–515. doi: 10.1016/0960-0760(91)90270-F. PubMed DOI
Sandberg K, Ji H. Sex and the renin angiotensin system: implications for gender differences in the progression of kidney disease. Adv Ren Replace Ther. 2003;10(1):15–23. doi: 10.1053/jarr.2003.50006. PubMed DOI