The importance of natural products in medicine, and in particular, plant secondary metabolites used for the treatment of diseases and drug development, has been obvious for several thousands of years [...].

Department of Chemistry of Natural Compounds University of Chemistry and Technology Technicka 5 166 28 Prague Czech Republic

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Linder T., Papaplioura E., Ogurlu D., Geyrhofer S., Hummelbrunner S., Schachner D., Atanasov A.G., Mihovilovic M.D., Dirsch V.M., Schnürch M. Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents. Biomedicines. 2022;10:62. doi: 10.3390/biomedicines10010062. PubMed DOI PMC

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Mattoteia D., Schiano Moriello A., Taglialatela-Scafati O., Amodeo P., De Petrocellis L., Appendino G., Vitale R.M., Caprioglio D. The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs. Biomedicines. 2021;9:1070. doi: 10.3390/biomedicines9081070. PubMed DOI PMC

Özdemir Z., Bildziukevich U., Čapková M., Lovecká P., Rárová L., Šaman D., Zgarbová M., Lapuníková B., Weber J., Kazakova O., et al. Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects. Biomedicines. 2021;9:951. doi: 10.3390/biomedicines9080951. PubMed DOI PMC

Gao W.-Y., Chen P.-Y., Hsu H.-J., Lin C.-Y., Wu M.-J., Yen J.-H. Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells. Biomedicines. 2021;9:326. doi: 10.3390/biomedicines9030326. PubMed DOI PMC

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Nocito M.C., De Luca A., Prestia F., Avena P., La Padula D., Zavaglia L., Sirianni R., Casaburi I., Puoci F., Chimento A., et al. Antitumoral Activities of Curcumin and Recent Advances to Improve Its Oral Bioavailability. Biomedicines. 2021;9:1476. doi: 10.3390/biomedicines9101476. PubMed DOI PMC

Yang L., Wang Z. Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer. Biomedicines. 2021;9:689. doi: 10.3390/biomedicines9060689. PubMed DOI PMC

Dinan L., Dioh W., Veillet S., Lafont R. 20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases. Biomedicines. 2021;9:492. doi: 10.3390/biomedicines9050492. PubMed DOI PMC

Christensen S.B. Natural Products That Changed Society. Biomedicines. 2021;9:472. doi: 10.3390/biomedicines9050472. PubMed DOI PMC

Oultram J.M.J., Pegler J.L., Bowser T.A., Ney L.J., Eamens A.L., Grof C.P.L. Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC. Biomedicines. 2021;9:234. doi: 10.3390/biomedicines9030234. PubMed DOI PMC