Cannabidiol (CBD), a non-psychotropic cannabinoid produced by the genus Cannabis, is a phytoceutical that activates the endocannabinoid system (ECS) through binding to CB1 and CB2 receptors. The ECS is involved in cellular homeostasis and regulates metabolic processes in virtually all mammalian tissues. Published studies on CBD focus, inter alia, on its use in prophylaxis and as an anti-inflammatory agent. Here the authors present a critical assessment of the effects of CBD on inflammatory periodontal diseases caused by bacterial virulence factors, and evaluate critically the possible benefits and drawbacks of CBD use in dentistry. Particular attention is paid to the interaction of CBD with microbially colonized oral tissues, the inflammatory response in relation to the immune response, and the destruction/regeneration of hard and soft tissues of the periodontium.

Department of Advanced Materials and Organic Synthesis Institute of Chemical Process Fundamentals of the Czech Academy of Sciences v v i Rozvojova 135 165 02 Prague 6 Czech Republic

Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palacky University Olomouc Hnevotinska 3 775 15 Olomouc Czech Republic

Institute of Dentistry and Oral Sciences Faculty of Medicine and Dentistry Palacky University Olomouc Palackeho 12 779 00 Olomouc Czech Republic

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