Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.

1st Department of Psychiatry Medical School National and Kapodistrian University of Athens Eginition Hospital Athens Greece

2nd Opinion Outpatient Clinic GGNet Mental Health Warnsveld The Netherlands

Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University Qingdao University Qingdao China

Altrecht General Menthal Health Care Utrecht The Netherlands

Analytic and Translational Genetics Unit Department of Medicine Department of Neurology and Department of Psychiatry Massachusetts General Hospital Boston MA USA

Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA

APC Microbiome Ireland University College Cork Cork Ireland

Área de Psiquiatría Universidad de Oviedo Hospital Universitario Central de Asturias Asturias Spain

Arkin Institute for Mental Health Amsterdam The Netherlands

Asfalia Biologics iPEPS ICM Hôpital Universitaire de la Pitié Salpêtrière Paris France

Australian Centre for Precision Health University of South Australia Cancer Research Institute University of South Australia Adelaide South Australia Australia

Baker Heart and Diabetes Institute Melbourne Victoria Australia

Banner University Medical Center Phoenix AZ USA

Barnet Enfield and Haringey Mental Health NHS Trust St Ann's Hospital London UK

Berlin Institute of Health Berlin Germany

Berlin School of Mind and Brain Humboldt Universität zu Berlin Berlin Germany

Bio 10 Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai China

BIOARABA Health Research Institute OSI Araba University Hospital University of the Basque Country Vitoria Spain

Biogen Cambridge MA USA

Biomedical Research Institute INCLIVA Valencia Spain

Black Dog Institute University of New South Wales Randwick New South Wales Australia

Brain and Mind Centre The University of Sydney Sydney New South Wales Australia

Broad Institute of MIT and Harvard Cambridge MA USA

Bulgarian Academy of Science Sofia Bulgaria

Cambridge Health Alliance Cambridge MA USA

Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada

Castle Peak Hospital Hong Kong China

Center for Behavioral Genomics Department of Psychiatry University of California San Diego La Jolla CA USA

Center for Bioinformatics Department of Informatics University of Oslo Oslo Norway

Center for Depression Anxiety and Stress Research McLean Hospital Belmont MA USA

Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China

Center for Genomics and Personalized Medicine Aarhus Denmark

Center for GeoGenetics GLOBE Institute University of Copenhagen Copenhagen Denmark

Center for Neonatal Screening Department for Congenital Disorders Statens Serum Institut Copenhagen Denmark

Center for Neurobehavioral Genetics Semel Institute for Neuroscience and Human Behavior University of California Los Angeles Los Angeles CA USA

Center for Neuropsychiatric Research National Health Research Institutes Zhunan Town Taiwan

Center for Psychiatric Genetics NorthShore University HealthSystem Evanston IL USA

Center for Psychopharmacology Diakonhjemmet Hospital Oslo Norway

Center for Translational Medicine The 1st Affiliated Hospital of Xi'an Jiaotong University Xi'an China

Centre de Référence des Maladies Rares à Expression Psychiatrique Department of Child and Adolescent Psychiatry AP HP Sorbonne Université Hôpital Universitaire de la Pitié Salpêtrière Paris France

Centre for Brain and Mental Health Research University of Newcastle Newcastle New South Wales Australia

Centre for Clinical Research in Neuropsychiatry University of Western Australia Perth Western Australia Australia

Centre for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK

Centre for Human Genetics University of Marburg Marburg Germany

Centre for Neuroimaging Cognition and Genomics National University of Ireland Galway Galway Ireland

Centre for PanorOmic Sciences LKS Faculty of Medicine The University of Hong Kong Hong Kong China

Centre for Psychiatry Queen Mary University London London UK

Centre for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services Stockholm Region Stockholm Sweden

Centre for Public Health Institute of Clinical Sciences Queen's University Belfast Belfast UK

Centre Hospitalier du Rouvray Rouen France

Centro de Investigación Biomédica en Red de Salud Mental Oviedo Asturias Spain

Centro de Investigación Biomédica en Red en Salud Mental Madrid Spain

Children's Hospital of Philadelphia Leonard Madlyn Abramson Research Center Philadelphia PA USA

Clinic of Psychiatry and Psychotherapy Weißer Hirsch Dresden Germany

Clinical Neuroscience Max Planck Institute of Experimental Medicine Göttingen Germany

Cognitive Neuropsychiatry Laboratory Department of Psychiatry and Psychotherapy Philipps Universität Marburg Marburg Germany

College of Medicine SUNY Downstate Health Sciences University New York NY USA

College of Public Health China Medical University Taichung Taiwan

Comedicum Lindwurmhof Munich Germany

Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA USA

Dementia Research Institute Cardiff University Cardiff UK

Department for Neurodegenerative Diseases and Geriatric Psychiatry University Hospital Bonn Bonn Germany

Department for Neurosciences Center for Contextual Psychiatry KU Leuven Leuven Belgium

Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology and Neuroscience King's College London London UK

Department of Basic Medical Science Neuroscience and Sense Organs University of Bari 'Aldo Moro' Bari Italy

Department of Biochemistry and Molecular Biology 2 Faculty of Pharmacy University of Granada Granada Spain

Department of Biology and Medical Genetics 2nd Faculty of Medicine and University Hospital Motol Prague Czech Republic

Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy

Department of Biomedical Data Science Stanford University Stanford CA USA

Department of Biomedicine Aarhus University Aarhus Denmark

Department of Biomedicine and Centre for Integrative Sequencing Aarhus University Aarhus Denmark

Department of Biomedicine University of Basel Basel Switzerland

Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA USA

Department of Cell Biology State University of New York Downstate Health Sciences University New York NY USA

Department of Cellular Computational and Integrative Biology University of Trento Trento Italy

Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health General Universitario Gregorio Marañón School of Medicine Universidad Complutense IiSGM Madrid Spain

Department of Clinical and Developmental Neuropsychology University of Groningen Groningen The Netherlands

Department of Clinical Genetics Center for Neurogenomics and Cognitive Research University Medical Center Amsterdam Amsterdam The Netherlands

Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Department of Clinical Sciences Psychiatry Umeå University Umeå Sweden

Department of Community Health and Epidemiology Dalhousie University Halifax Nova Scotia Canada

Department of Complex Trait Genetics Center for Neurogenomics and Cognitive Research Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam The Netherlands

Department of Computer Science University of North Carolina Chapel Hill NC USA

Department of Epidemiology University Medical Center Groningen University of Groningen Groningen The Netherlands

Department of Evolutionary Biology Ecology and Environmental Sciences Faculty of Biology University of Barcelona Barcelona Spain

Department of Functional Genomics Faculty of Exact Science Center for Neurogenomics and Cognitive Research VU University Amsterdam and VU Medical Center Amsterdam The Netherlands

Department of General Practice and Primary Health Care University of Helsinki and Helsinki University Hospital Helsinki Finland

Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Mannheim Germany

Department of Genetics and Genomic Sciences and Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA

Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA

Department of Genetics and Pathology International Hereditary Cancer Center Pomeranian Medical University in Szczecin Szczecin Poland

Department of Genetics Faculty of Biological Sciences Universidad de Valencia Valencia Spain

Department of Genetics Faculty of Biology Sofia University St Kliment Ohridski Sofia Bulgaria

Department of Genetics University of North Carolina Chapel Hill NC USA

Department of Health Data Science University of Liverpool Liverpool UK

Department of Health Sciences University of Leicester Leicester UK

Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA

Department of Human Molecular Genetics of the Institute of Biochemistry and Genetics of the Ufa Federal Research Center of the Russian Academy of Sciences Ufa Russia

Department of Mathematics and Statistics University of Helsinki Helsinki Finland

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

Department of Medical Genetics Medical School University of Pécs Pécs Hungary

Department of Medical Genetics Medical University Sofia Bulgaria

Department of Medical Genetics Oslo University Hospital Oslo Norway

Department of Medical Genetics University Medical Centre Utrecht Utrecht The Netherlands

Department of Medical Genetics University of Pécs School of Medicine Pécs Hungary

Department of Medicine Harvard Medical School Boston MA USA

Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

Department of Mental Health ASL Rome 1 Rome Italy

Department of Mental Health Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA

Department of Mental Health Norwegian University of Science and Technology Trondheim Norway

Department of Molecular and Cellular Neurobiology Center for Neurogenomics and Cognitive Research Faculty of Science Amsterdam Neuroscience Vrije Universiteit Amsterdam The Netherlands

Department of Molecular and Translational Medicine University of Brescia Brescia Italy

Department of Morphology and Genetics Laboratorio de Genetica Universidade Federal de São Paulo São Paulo Brazil

Department of Neurology Medical University of Vienna Vienna Austria

Department of Neuroscience Biomedicine and Movement Sciences Section of Psychiatry University of Verona Verona Italy

Department of Neuroscience Dokuz Eylül University Graduate School of Health Sciences Izmir Turkey

Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA

Department of Neurosciences Center for Clinical Psychiatry KU Leuven Leuven Belgium

Department of Nursing Faculty of Health Sciences and Biomedical Research Centre University of Granada Granada Spain

Department of Obstetrics and Gynecology Yong Loo Lin School of Medicine National University of Singapore Singapore Republic of Singapore

Department of Pharmacy University of Oslo Oslo Norway

Department of Preventative Medicine Faculdade de Medicina FMUSP University of São Paulo São Paulo Brazil

Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Department of Psychiatry 1st Faculty of Medicine and General University Hospital Prague Czech Republic

Department of Psychiatry Academic Medical Centre University of Amsterdam Amsterdam The Netherlands

Department of Psychiatry and Behavioral Neurosciences The University of Chicago Chicago IL USA

Department of Psychiatry and Behavioral Sciences Emory University Atlanta GA USA

Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore MD USA

Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USA

Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University Syracuse NY USA

Department of Psychiatry and Behavioral Sciences The Johns Hopkins University Baltimore MD USA

Department of Psychiatry and Behavioral Sciences University of Washington Seattle WA USA

Department of Psychiatry and Behavioural Health Stony Brook University Stony Brook NY USA

Department of Psychiatry and Biobehavioral Sciences Geffen School of Medicine University of California Los Angeles Los Angeles CA USA

Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles Los Angeles CA USA

Department of Psychiatry and Human Behavior School of Medicine University of California Irvine Irvine CA USA

Department of Psychiatry and Neurobehavioural Sciences University College Cork Cork Ireland

Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University Medical Centre Maastricht The Netherlands

Department of Psychiatry and Psychotherapy Charité Universitätsmedizin Berlin Germany

Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany

Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria

Department of Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany

Department of Psychiatry and SleepWell Research Program Faculty of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland

Department of Psychiatry and the Behavioral Sciences Keck School of Medicine University of Southern California Los Angeles CA USA

Department of Psychiatry and the Behavioral Sciences SUNY Downstate Medical Center New York NY USA

Department of Psychiatry and Zilkha Neurogenetics Institute Keck School of Medicine at University of Southern California Los Angeles CA USA

Department of Psychiatry Charité Universitätsmedizin Berlin Berlin Germany

Department of Psychiatry Charité Universitätsmedizin Berlin Germany

Department of Psychiatry Chonnam National University Medical School Gwangju Korea

Department of Psychiatry College of Medicine and National Taiwan University Hospital National Taiwan University Taipei Taiwan

Department of Psychiatry Columbia University New York NY USA

Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada

Department of Psychiatry Dokuz Eylül University School of Medicine Izmir Turkey

Department of Psychiatry Erasmus University Medical Center Rotterdam The Netherlands

Department of Psychiatry Faculty of Medicine and Biomedical Research Centre University of Granada Granada Spain

Department of Psychiatry Faculty of Medicine Istanbul University Istanbul Turkey

Department of Psychiatry Fujita Health University School of Medicine Toyoake Aichi Japan

Department of Psychiatry GGz Centraal Utrecht The Netherlands

Department of Psychiatry Hadassah Hebrew University Medical Center Jerusalem Israel

Department of Psychiatry Harvard Medical School Boston MA USA

Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA

Department of Psychiatry Irmandade da Santa Casa de Misericórdia de São Paulo São Paulo Brazil

Department of Psychiatry Landspitali University Hospital Reykjavik Iceland

Department of Psychiatry LKS Faculty of Medicine The University of Hong Kong Hong Kong China

Department of Psychiatry Massachusetts General Hospital Boston MA USA

Department of Psychiatry McGill University Montreal Québec Canada

Department of Psychiatry Melbourne Medical School University of Melbourne Parkville Victoria Australia

Department of Psychiatry Monash University Melbourne Victoria Australia

Department of Psychiatry National Taiwan University Hospital Taipei Taiwan

Department of Psychiatry Pamela Sklar Division of Psychiatric Genomics Friedman Brain Institute Department of Genetics and Genomic Science and Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA

Department of Psychiatry Phoenix VA Healthcare System Phoenix AZ USA

Department of Psychiatry Psychosomatics and Psychotherapy Julius Maximilians Universität Würzburg Würzburg Germany

Department of Psychiatry Queens University Kingston Kingston Ontario Canada

Department of Psychiatry Research Unit of Clinical Neuroscience University of Oulu Oulu Finland

Department of Psychiatry Royal College of Surgeons in Ireland Dublin Ireland

Department of Psychiatry San Cecilio University Hospital University of Granada Granada Spain

Department of Psychiatry School of Medicine Ankara University Ankara Turkey

Department of Psychiatry School of Medicine University of Valencia Hospital Clínico Universitario de Valencia Valencia Spain

Department of Psychiatry Semel Institute David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA

Department of Psychiatry Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea

Department of Psychiatry The 1st Affiliated Hospital of Xi'an Jiaotong University Xi'an China

Department of Psychiatry The Chinese University of Hong Kong Hong Kong China

Department of Psychiatry UMC Utrecht Brain Center University Medical Centre Utrecht Utrecht University Utrecht The Netherlands

Department of Psychiatry Universidade Federal de São Paulo São Paulo Brazil

Department of Psychiatry University of California San Diego La Jolla CA USA

Department of Psychiatry University of California San Francisco San Francisco CA USA

Department of Psychiatry University of Colorado Denver Aurora CO USA

Department of Psychiatry University of Helsinki Helsinki Finland

Department of Psychiatry University of Iowa Carver College of Medicine Iowa City IA USA

Department of Psychiatry University of Melbourne Parkville Victoria Australia

Department of Psychiatry University of Münster Münster Germany

Department of Psychiatry University of North Carolina Chapel Hill NC USA

Department of Psychiatry University of Oxford Oxford UK

Department of Psychiatry University of Pennsylvania Philadelphia PA USA

Department of Psychiatry University of Pittsburgh Pittsburgh PA USA

Department of Psychiatry University of Toronto Toronto Ontario Canada

Department of Psychiatry Veterans Affairs New York Harbor Healthcare System New York NY USA

Department of Psychiatry Washington University St Louis MO USA

Department of Psychiatry Wright State University Dayton OH USA

Department of Psychiatry Yale School of Medicine New Haven CT USA

Department of Psychiatry Zucker School of Medicine at Hofstra Northwell Hempstead NY USA

Department of Psychological Medicine Institute of Psychiatry Psychology and Neuroscience King's College London London UK

Department of Psychology Harvard University Cambridge MA USA

Department of Psychology University of Chinese Academy of Sciences Beijing China

Department of Psychosis Institute of Mental Health Singapore Singapore

Department of Psychosis Studies Institute of Psychiatry Psychology and Neuroscience King's College London London UK

Department of Public Health Solutions Genomics and Biomarkers Unit National Institute for Health and Welfare Helsinki Finland

Department of Public Health University of Helsinki Helsinki Finland

Department of Statistics and Applied Probability University of California at Santa Barbara Santa Barbara CA USA

Department of Stem Cell and Regenerative Biology Harvard University Cambridge MA USA

Department of Translational Neuroscience UMC Utrecht Brain Center University Medical Center Utrecht Utrecht University Utrecht The Netherlands

Departments of Psychiatry and Human and Molecular Genetics INSERM Institut de Myologie Hôpital de la Pitiè Salpêtrière Paris France

Departments of Psychiatry and Human Genetics University of Chicago Chicago IL USA

Departments of Psychiatry and Neuroscience and Physiology SUNY Upstate Medical University Syracuse NY USA

Departments of Public Health and Preventive Medicine Family Medicine and Psychiatry and Behavioral Sciences State University of New York Upstate Medical University Syracuse NY USA

Dipartimento di Biologia Universita' di Pisa Pisa Italy

Discipline of Psychiatry Adelaide Medical School University of Adelaide Adelaide South Australia Australia

Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA

Division of Medical Genetics Department of Biomedicine University of Basel Basel Switzerland

Division of Mental Health and Addiction Oslo University Hospital Oslo Norway

Division of Mental Health St Olav's Hospital Trondheim University Hospital Trondheim Norway

Division of Molecular Medicine NSW Health Pathology North Newcastle New South Wales Australia

Division of Psychiatric Genomics Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA

Division of Psychiatry Centre for Clinical Brain Sciences University of Edinburgh Royal Edinburgh Hospital Edinburgh UK

Division of Psychiatry Department of Mental Health Neuroscience University College London London UK

Division of Psychiatry Research Zucker Hillside Hospital Glen Oaks NY USA

Early Clinical Development Pfizer Worldwide Research and Development Groton CT USA

eCODE Genetics Amgen Reykjavik Iceland

Eli Lilly and Company Windlesham UK

Estonian Genome Center Institute of Genomics University of Tartu Tartu Estonia

Faculté de Médecine Sorbonne Université Groupe de Recherche Clinique no 15 Troubles Psychiatriques et Développement Department of Child and Adolescent Psychiatry Hôpital Universitaire de la Pitié Salpêtrière Paris France

Faculty of Medicine University of Iceland Reykjavik Iceland

Faculty of Medicine Vilnius University Vilnius Lithuania

Faculty of Science Medicine and Health University of Wollongong Wollongong New South Wales Australia

Federal State Educational Institution of Highest Education Bashkir State Medical University of Public Health Ministry of Russian Federation Ufa Russia

Folkhälsan Research Center Helsinki Finland

Généthon Evry France

Genetic Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

Harvard Medical School Department of Psychiatry at Beth Israel Deaconess Medical Center Boston MA USA

Health Science Center University of Tennessee Memphis TN USA

Hospital Universitari Institut Pere Mata IISPV Universitat Rovira i Virgili CIBERSAM Reus Spain

Hospital Universitario Virgen del Rocio Department of Psychiatry Universidad del Sevilla Seville Spain

Human Genetics Genome Institute of Singapore A*STAR Singapore Singapore

Hunter Medical Research Institute Newcastle New South Wales Australia

Hunter New England Health and University of Newcastle Newcastle New South Wales Australia

Huntsman Mental Health Institute Department of Psychiatry University of Utah School of Medicine Salt Lake City UT USA

Illawarra Health and Medical Research Institute Wollongong New South Wales Australia

INSERM Rouen France

INSERM U1266 Institut de Psychiatrie et de Neurosciences Paris France

INSERM U1266 Institute of Psychiatry and Neuroscience of Paris Université de Paris GHU Paris Psychiatrie and Neurosciences Paris France

Institut de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut Universitat Pompeu Fabra PRBB Barcelona Spain

Institut des Systèmes Intelligents et de Robotique CNRS UMR7222 Faculté des Sciences et Ingénierie Sorbonne Université Paris France

Institute for Behavioural Genetics University of Colorado Boulder Boulder CO USA

Institute for Genomic Health SUNY Downstate Medical Center New York NY USA

Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia

Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland

Institute of Behavioral Science Feinstein Institutes for Medical Research Manhasset NY USA

Institute of Biological Psychiatry Mental Health Services Copenhagen University Hospital Copenhagen Denmark

Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan

Institute of Genomic Medicine University of California San Diego La Jolla CA USA

Institute of Human Genetics University of Bonn Bonn Germany

Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland

Institute of Medical Psychology Faculty of Medicine University of Coimbra Coimbra Portugal

Institute of Medical Sciences University of Aberdeen Aberdeen UK

Institute of Molecular Genetics of National Research Centre Kurchatov Institute Moscow Russia

Institute of Neuroscience and Medicine Research Center Juelich Juelich Germany

Institute of Neurosciences Biomedical Research Center University of Granada Granada Spain

Institute of Psychiatric Phenomics and Genomics University Hospital LMU Munich Munich Germany

Institute of Psychology Chinese Academy of Science Beijing China

Instituto de Investigación Sanitaria del Principado de Asturias Oviedo Asturias Spain

Instituto de Investigación Sanitaria Santiago de Compostela Spain

James J Peters VA Medical Center Bronx NY USA

Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan

Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan

Laboratory of Complex Trait Genomics Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan

Laboratory of Integrative Neuroscience Universidade Federal de São Paulo São Paulo Brazil

Latvian Biomedical Research and Study Centre Riga Latvia

Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore

Lieber Institute for Brain Development Baltimore MD USA

Massachusetts Mental Health Center Boston MA USA

Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center Boston MA USA

Mater Research Institute University of Queensland Brisbane Queensland Australia

Max Planck Institute of Psychiatry Munich Germany

Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland

Melbourne Neuropsychiatry Centre University of Melbourne and Melbourne Health Melbourne Victoria Australia

Melbourne School of Population and Global Health University of Melbourne Melbourne Victoria Australia

Mental Health Research Center Moscow Russian Federation

Mental Health Services in the Capital Region of Denmark Mental Health Center Copenhagen University of Copenhagen Copenhagen Denmark

Mental Health Unit Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland

Mental Illness Research Clinical and Education Center JJ Peters VA Medical Center New York NY USA

Mental Illness Research Education and Clinical Center James J Peters VA Medical Center New York NY USA

Menzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia

Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland

Molecular Psychiatry Laboratory Division of Psychiatry University College London London UK

MRC Centre for Neuropsychiatric Genetics and Genomics Division of Psychological Medicine and Clinical Neurosciences Cardiff University Cardiff UK

MRC Human Genetics Unit University of Edinburgh Institute of Genetics and Cancer Western General Hospital Edinburgh UK

Munich Cluster for Systems Neurology Munich Germany

National Centre for Register based Research Aarhus University Aarhus Denmark

National Clinical Research Center for Mental Disorders NHC Key Laboratory of Mental Health and Chinese Academy of Medical Sciences Research Unit Beijing China

National Institute for Health Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London London UK

Neurobiology and Cognitive Science Center National Taiwan University Taipei Taiwan

Neuropsychiatric Epidemiology Research Unit School of Population and Global Health University of Western Australia Perth Western Australia Australia

Neuropsychiatric Genetics Research Group Department of Psychiatry Trinity College Dublin Dublin Ireland

Neuroscience and Mental Health Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore

Neuroscience Research Australia Sydney New South Wales Australia

Neuroscience Therapeutic Area Janssen Research and Development Titusville NJ USA

NORMENT Centre Department of Clinical Science University of Bergen Bergen Norway

NORMENT Centre Division of Mental Health and Addiction University of Oslo Oslo Norway

NORMENT Centre Institute of Clinical Medicine University of Oslo Oslo Norway

Northern Adelaide Local Health Network Adelaide South Australia Australia

NorthWestern Mental Health Melbourne Victoria Australia

Oxford Health NHS Foundation Trust Oxford UK

Oxford Health NHS Foundation Trust Warneford Hospital Oxford UK

Peking University Sixth Hospital Peking University Institute of Mental Health Beijing China

PKU IDG McGovern Institute for Brain Research Peking University Beijing China

Priority Centre for Brain and Mental Health Research University of Newcastle Mater Hospital McAuley Centre Newcastle New South Wales Australia

Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA

Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine Massachusetts General Hospital Boston MA USA

Psychiatric and Neurodevelopmental Genetics Unit Department of Psychiatry and Center for Genomic Medicine Massachusetts General Hospital Harvard Medical School Boston MA USA

Psychiatric Clinic Alexandrovska University Hospital Sofia Bulgaria

Psychiatric Genetic Epidemiology and Neurobiology Laboratory Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University Syracuse NY USA

Psychiatry Department University of Indonesia Cipto Mangunkusumo National General Hospital Jakarta Indonesia

Psychiatry Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

Psychosis Research Unit Aarhus University Hospital Aarhus Denmark

Queensland Brain Institute University of Queensland Brisbane Queensland Australia

Queensland Centre for Mental Health Research The Park Centre for Mental Health Brisbane Queensland Australia

Queensland Centre for Mental Health Research University of Queensland Brisbane Queensland Australia

Ramsay Health Care Mental Health Adelaide South Australia Australia

Regeneron Genetics Center Orange CA USA

Regional Centre for Clinical Research in Psychosis Department of Psychiatry Stavanger University Hospital Stavanger Norway

Research Division Institute of Mental Health Singapore Republic of Singapore

Rheumatology Research Group Vall d'Hebron Research Institute Barcelona Spain

RIKEN Center for Integrative Medical Sciences Yokohama Japan

Roche Pharma Research and Early Development Pharmaceutical Sciences Roche Innovation Center Basel F Hoffman La Roche Basel Switzerland

Roche Pharma Research and Early Development Roche Innovation Center Basel F Hoffman La Roche Basel Switzerland

Rutgers University New Jersey Medical School Newark NJ USA

Rutgers University Robert Wood Johnson Medical School New Brunswick NJ USA

Saw Swee Hock School of Public Health National University of Singapore Singapore Republic of Singapore

School of Biomedical Sciences and Pharmacy University of Newcastle Newcastle New South Wales Australia

School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China

School of Life Science and Technology ShanghaiTech University Shanghai China

School of Life Sciences Westlake University Hangzhou China

School of Medicine and Public Health University of Newcastle Newcastle New South Wales Australia

School of Medicine University of Queensland Herston Queensland Australia

School of Nursing Louisiana State University Health Sciences Center New Orleans LA USA

School of Psychiatry and Clinical Neurosciences University of Western Australia Perth Western Australia Australia

School of Psychiatry University of New South Wales Sydney New South Wales Australia

School of Psychology University of Newcastle Newcastle New South Wales Australia

School of Social and Health Sciences Leeds Trinity University Leeds UK

Semel Institute for Neurosciene University of California Los Angeles Los Angeles CA USA

Servizo de Psiquiatría Complexo Hospitalario Universitario de Santiago de Compostela Servizo Galego de Saúde Santiago de Compostela Spain

Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China

Sheba Medical Center Tel Hashomer Israel

Sheppard Pratt Health System Baltimore MD USA

Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology and Neuroscience King's College London London UK

South Australian Health and Medical Research Institute Adelaide South Australia Australia

South London and Maudsley NHS Mental Health Foundation Trust London UK

St Vincent's Hospital Melbourne Victoria Australia

Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA

Stanley Neurovirology Laboratory Johns Hopkins University School of Medicine Baltimore MD USA

State Key Laboratory of Brain and Cognitive Sciences LKS Faculty of Medicine The University of Hong Kong Hong Kong China

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center of Genetics and Development Human Phenome Institute School of Life Sciences Fudan University Shanghai China

SUNY Upstate Medical University Syracuse NY USA

The Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria Australia

The Lundbeck Foundation Initiative for Integrative Psychiatric Research Aarhus Denmark

The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Copenhagen Denmark

THL Finnish Institute for Health and Welfare Helsinki Finland

TIPS Network for Clinical Research in Psychosis Stavanger University Hospital Stavanger Norway

UCL Genetics Institute University College London London UK

UFR Santé Université de Rouen Normandie Rouen France

UniSA Allied Health and Human Performance University of South Australia Adelaide South Australia Australia

Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma and San Raffaele University Rome Italy

Université de Paris Faculté de Médecine Hôpital Cochin Tarnier Paris France

University Medical Center Groningen University Center for Psychiatry Rob Giel Research Center University of Groningen Groningen The Netherlands

University Medical Center Utrecht Department of Psychiatry Rudolf Magnus Institute of Neuroscience Utrecht The Netherlands

University Medical Center Utrecht Department of Psychiatry Utrecht The Netherlands

University of Nicosia Medical School Nicosia Cyprus

University of Sevilla CIBERSAM IBiS Seville Spain

VA Boston Health Care System Brockton MA USA

VA Greater Los Angeles Healthcare System Los Angeles CA USA

VA Puget Sound Health Care System Seattle WA USA

Virginia Institute for Psychiatric and Behavioral Genetics Department of Psychiatry Virginia Commonwealth University Richmond VA USA

VISN 22 Mental Illness Research Education and Clinical Center VA San Diego Healthcare System San Diego CA USA

West Region Institute of Mental Health Singapore Singapore

Westlake Laboratory of Life Sciences and Biomedicine Hangzhou China

Yoo Loo Lin School of Medicine National University of Singapore Singapore Singapore

Zhongshan School of Medicine and Key Laboratory of Tropical Diseases Control Sun Yat sen University Guangzhou China

Comment In

Nature. 2022 Apr;604(7906):433-435. doi: 10.1038/d41586-022-00773-5. PubMed

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Fine-mapping genomic loci refines bipolar disorder risk genes

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Review: Genes Involved in Mitochondrial Physiology Within 22q11.2 Deleted Region and Their Relevance to Schizophrenia