Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
35583791
PubMed Central
PMC9526693
DOI
10.1007/s12223-022-00977-2
PII: 10.1007/s12223-022-00977-2
Knihovny.cz E-zdroje
- Klíčová slova
- Gut dysbiosis, Gut-Brain Axis, Microbial Metabolites, Microbiome, Parkinson’s Disease,
- MeSH
- alfa-synuklein metabolismus MeSH
- antiparkinsonika MeSH
- lidé MeSH
- mozek MeSH
- Parkinsonova nemoc * terapie MeSH
- střevní mikroflóra * fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- alfa-synuklein MeSH
- antiparkinsonika MeSH
Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.
Department of Medicine University of Cambridge Cambridge UK
Department of Neurology Bharati Vidyapeeth Medical College and Hospital Pune India
Department of Neurology Kasturba Medical College Manipal Academy of Higher Education Manipal India
National Institute of Cholera and Enteric Diseases Kolkata India
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