Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if not treated, can result in serious health consequences for the mother and the child. Flavonoids are bioactive secondary metabolites commonly found in fruits, vegetables, green tea, whole grains, and medicinal plants. Flavonoids exert potent protective efficacy in experimental models of hypertensive disorders in pregnancy, especially preeclampsia, demonstrated through their capacity to modulate inflammatory responses, oxidative stress, and vascular dysfunction. In addition to their potential as therapeutics, flavonoids or flavonoid-rich food could be helpful to decrease the risk of hypertensive disorders in pregnancy when included in the diet pattern before and during pregnancy. However, the clinical evaluation of the potential capacity of flavonoids in hypertensive disorders in pregnancy is insufficient. Due to promising results from experimental studies, we highlight the need for the evaluation of flavonoids also in an appropriate clinical setting, which can be, together with proper preventive strategies, helpful in the overall management of hypertensive disorders in pregnancy.

1st Department of Internal Diseases University Hospital Martin and Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia

Clinic of Obstetrics and Gynecology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Internal Medicine Faculty of Medicine Comenius University and University Hospital Bratislava Slovakia

Department of Medical Biology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Pathological Physiology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Pharmacology Faculty of Medicine Pavol Jozef Safarik University Kosice Slovakia

Department of Physiology and Biophysics Weill Cornell Medicine Qatar Education City Qatar Foundation Doha Qatar

Department of Surgery Faculty of Medicine Masaryk University and St Annés University Hospital Brno Czech Republic

Department of Thoracic Surgery Medical University of Silesia Katowice Poland

European Association for Predictive Preventive and Personalised Medicine EPMA Brussels Belgium; Predictive Preventive and Personalised Medicine Department of Radiation Oncology University Hospital Bonn Rheinische Friedrich Wilhelms Universität Bonn Bonn Germany

Faculty of Health Sciences University of Ss Cyril and Methodius in Trnava Trnava Slovakia

International Clinical Research Centre Masaryk University and St Annés University Hospital Brno Czech Republic; 2 Department of Internal Medicine Faculty of Medicine Masaryk University and St Annés University Hospital Brno Czech Republic

International Research Centre Biotechnologies of the 3rd Millennium Faculty of Biotechnologies ITMO University Saint Petersburg Russian Federation

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