The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
HRA-POS/2013/397
Health Research Board of Ireland
31312020
International Hundred K+ Cohorts Consortium/Global Genomic Medicine Collaborative (IHCC/G2MC)
GACR 20-03997S
Czech Science Foundation
VV 22-05942S
Czech Science Foundation
AZV NV18-03-00199
Czech Health Research council of the Ministry of Health of the Czech Republic
PubMed
35807897
PubMed Central
PMC9268344
DOI
10.3390/nu14132718
PII: nu14132718
Knihovny.cz E-zdroje
- Klíčová slova
- Selenium, Selenium pathway, case–control cohorts, colorectal cancer risk, colorectal neoplasms, selenoprotein gene variation,
- MeSH
- adenom * epidemiologie genetika MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus MeSH
- kolorektální nádory * epidemiologie genetika MeSH
- lidé MeSH
- prospektivní studie MeSH
- selenoprotein P metabolismus MeSH
- selenoproteiny genetika metabolismus MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- selenoprotein P MeSH
- selenoproteiny MeSH
BACKGROUND: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case-control cohort. METHODS: We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case-control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development. RESULTS: We found significant associations with an increased CRC risk for rs5859 (SELENOF) and rs2972994 (SELENOP) in the Irish cohort but only with rs4802034 (SELENOV) in the Czechs. Significant associations were observed for rs5859 (SELENOF), rs4659382 (SELENON), rs2972994 (SELENOP), rs34713741 (SELENOS), and the related Se metabolism gene variant rs2275129 (SEPHS1) with advanced colorectal neoplasia development. However, none of these findings retained significance after multiple testing corrections. CONCLUSIONS: Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ.
Biomedical Centre Faculty of Medicine in Pilsen Charles University 323 00 Pilsen Czech Republic
Centre for Colorectal Disease St Vincent's University Hospital D04 T6F4 Dublin Ireland
Institute of Experimental Medicine ASCR 142 20 Prague Czech Republic
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