Lifestyle and dietary environmental factors in colorectal cancer susceptibility
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
001
World Health Organization - International
PubMed
31233770
DOI
10.1016/j.mam.2019.06.005
PII: S0098-2997(19)30033-0
Knihovny.cz E-zdroje
- Klíčová slova
- Colorectal cancer, Diet, Environment, Etiology, Genetic interactions, Lifestyle, Mechanisms, Obesity,
- MeSH
- dieta * MeSH
- genetická predispozice k nemoci MeSH
- hodnocení rizik MeSH
- interakce genů a prostředí MeSH
- interakce hostitele a patogenu MeSH
- kolorektální nádory epidemiologie etiologie MeSH
- léky na předpis škodlivé účinky MeSH
- lidé MeSH
- náchylnost k nemoci * MeSH
- obezita komplikace metabolismus MeSH
- rizikové faktory MeSH
- životní prostředí * MeSH
- životní styl * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- léky na předpis MeSH
Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum.
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