Lifestyle and dietary environmental factors in colorectal cancer susceptibility
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
001
World Health Organization - International
PubMed
31233770
DOI
10.1016/j.mam.2019.06.005
PII: S0098-2997(19)30033-0
Knihovny.cz E-resources
- Keywords
- Colorectal cancer, Diet, Environment, Etiology, Genetic interactions, Lifestyle, Mechanisms, Obesity,
- MeSH
- Diet * MeSH
- Genetic Predisposition to Disease MeSH
- Risk Assessment MeSH
- Gene-Environment Interaction MeSH
- Host-Pathogen Interactions MeSH
- Colorectal Neoplasms epidemiology etiology MeSH
- Prescription Drugs adverse effects MeSH
- Humans MeSH
- Disease Susceptibility * MeSH
- Obesity complications metabolism MeSH
- Risk Factors MeSH
- Environment * MeSH
- Life Style * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Prescription Drugs MeSH
Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum.
References provided by Crossref.org
