Invasive Aspergillus infection of middle ear in a patient treated with secukinumab, methotrexate, and corticosteroids for psoriasis and psoriatic arthritis
Language English Country England, Great Britain Media print-electronic
Document type Case Reports, Journal Article
- Keywords
- Aspergillosis, anti-IL-17, psoriasis, psoriatic arthritis, secukinumab,
- MeSH
- Aspergillosis * etiology complications MeSH
- Adult MeSH
- Adrenal Cortex Hormones MeSH
- Humans MeSH
- Methotrexate therapeutic use MeSH
- Arthritis, Psoriatic * complications drug therapy MeSH
- Psoriasis * drug therapy complications MeSH
- Ear, Middle MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Adrenal Cortex Hormones MeSH
- Methotrexate MeSH
- secukinumab MeSH Browser
Mucocutaneous mycotic infections are common complications in patients on IL-17 inhibitor therapy. We report a case of a 33-year-old male with severe psoriasis and psoriatic arthritis on secukinumab combined with methotrexate and prednisone with swelling, otorrhea, and pain of the right ear and external auditory canal. Due to progressive hypacusis, a surgical solution was chosen. Tissue samples taken during surgery revealed the presence of Aspergillus fumigatus. Aspergillosis should be suspected in prolonged otorrhea, especially in immunocompromised patients. Without intervention, the disease could be fatal.
Department of Radiology University Hospital Hradec Králové Hradec Králové Czech Republic
Department of Rheumatology Revma Praha Prague Czech Republic
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