INTRODUCTION: While the role of physiotherapy as part of a comprehensive inpatient rehabilitation is indisputable, clear evidence concerning the effectiveness of different rehabilitation managements [interdisciplinary implementing the International Classification of Functioning, disability and health (ICF) vs. multidisciplinary model] and physiotherapy categories (neuroproprioceptive "facilitation, inhibition" vs. motor/skill acquisitions using technologies) are still lacking. In this study, four kinds of comprehensive inpatient rehabilitation with different management and content of physical therapy will be compared. Moreover, focus will be placed on the identification of novel biological molecules reflective of effective rehabilitation. Long non-coding RNAs (lncRNAs) are transcripts (>200 bps) of limited coding potential, which have recently been recognized as key factors in neuronal signaling pathways in ischemic stroke and as such, may provide a valuable readout of patient recovery and neuroprotection during therapeutic progression. METHODS AND ANALYSIS: Adults after the first ischemic stroke in an early sub-acute phase with motor disability will be randomly assigned to one of four groups and undergo a 3 weeks comprehensive inpatient rehabilitation of different types: interdisciplinary team work using ICF model as a guide; multidisciplinary teamwork implementing neuroproprioceptive "facilitation and inhibition" physiotherapy; multidisciplinary teamwork implementing technology-based physiotherapy; and standard multidisciplinary teamwork. Primary (the Goal Attainment Scale, the Patient-Reported Outcomes Measurement Information System, and the World Health Organization Disability Assessment Schedule) and secondary (motor, cognitive, psychological, speech and swallowing functions, functional independence) outcomes will be measured. A blood sample will be obtained upon consent (20 mls; representing pre-rehabilitation molecular) before and after the inpatient program. Primary outcomes will be followed up again 3 and 12 months after the end of the program. The overarching aim of this study is to determine the effectiveness of various rehabilitation managements and physiotherapeutic categories implemented by patients post ischemic stroke via analysis of primary, secondary and long non-coding RNA readouts. This clinical trial will offer an innovative approach not previously tested and will provide new complex analysis along with public assessable molecular biological evidence of various rehabilitation methodology for the alleviation of the effects of ischemic stroke. CLINICAL TRIAL REGISTRATION: NCT05323916, https://clinicaltrials.gov/ct2/show/NCT05323916.

Department of Circuit Theory Faculty of Electrical Engineering Czech Technical University Prague Prague Czechia

Department of Medical Genetics 3rd Faculty of Medicine Charles University Prague Czechia

Department of Neurology 3rd Faculty of Medicine Charles University Prague Czechia

Department of Neurology 3rd Faculty of Medicine Thomayer University Hospital Charles University Prague Czechia

Department of Physical Medicine and Rehabilitation Military University Hospital Prague Prague Czechia

Department of Rheumatology and Rehabilitation 3rd Faculty of Medicine Thomayer University Hospital Charles University Prague Czechia

Department of Statistical Modelling Institute of Computer Science of the Czech Academy of Sciences Prague Czechia

University Hospital Kralovske Vinohrady Prague Czechia

See more in PubMed

Langhorne P, Coupar F, Pollock A. Motor recovery after stroke: a systematic review. Lancet Neurol. (2009) 8:741–54. 10.1016/S1474-4422(09)70150-4 PubMed DOI

Yagi M, Yasunaga H, Matsui H, Morita K, Fushimi K, Fujimoto M, et al. . Impact of rehabilitation on outcomes in patients with ischemic stroke: a nationwide retrospective cohort study in Japan. Stroke. (2017) 48:740–6. 10.1161/STROKEAHA.116.015147 PubMed DOI

Bindawas SM, Vennu V, Moftah E. Improved functions and reduced length of stay after inpatient rehabilitation programs in older adults with stroke: a systematic review and meta-analysis of randomized controlled trials. Neuro Rehabil. (2017) 40:369–90. 10.3233/NRE-161425 PubMed DOI

Bunketorp-Käll L, Lundgren-Nilsson Å, Samuelsson H, Pekny T, Blomvé K, Pekna M, et al. . Long-term improvements after multimodal rehabilitation in late phase after stroke: a randomized controlled trial. Stroke. (2017) 48:1916–24. 10.1161/STROKEAHA.116.016433 PubMed DOI

Hopman WM, Verner J. Quality of life during and after inpatient stroke rehabilitation. Stroke. (2003) 34:801–5. 10.1161/01.STR.0000092205.92969.00 PubMed DOI

Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet. (2011) 377:1693–702. 10.1016/S0140-6736(11)60325-5 PubMed DOI

Perin C, Bolis M, Limonta M, Meroni R, Ostasiewicz K, Cornaggia CM, et al. . Differences in rehabilitation needs after stroke: a similarity analysis on the ICF core set for stroke. Int J Environ Res Public Health. (2020) 17:4291. 10.3390/ijerph17124291 PubMed DOI PMC

Rasova K, Freeman J, Martinkova P, Pavlikova M, Cattaneo D, Jonsdottir J, et al. . The organisation of physiotherapy for people with multiple sclerosis across Europe: a multicentre questionnaire survey. BMC Health Serv Res. (2016) 16:552. 10.1186/s12913-016-1750-6 PubMed DOI PMC

Zhang T, Liu L, Xie R, Peng Y, Wang H, Chen Z, et al. . Value of using the international classification of functioning, disability, and health for stroke rehabilitation assessment: a multicenter clinical study. Medicine. (2018) 97:e12802. 10.1097/MD.0000000000012802 PubMed DOI PMC

Brewer L, Horgan F, Hickey A, Williams D. Stroke rehabilitation: recent advances and future therapies. QJM. (2013) 106:11–25. 10.1093/qjmed/hcs174 PubMed DOI

Johansson BB. Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurol Scand. (2011) 123:147–59. 10.1111/j.1600-0404.2010.01417.x PubMed DOI

Stinear CM, Lang CE, Zeiler S, Byblow WD. Advances and challenges in stroke rehabilitation. Lancet Neurol. (2020) 19:348–60. 10.1016/S1474-4422(19)30415-6 PubMed DOI

van Vliet PM, Lincoln NB, Foxall A. Comparison of Bobath based and movement science based treatment for stroke: a randomised controlled trial. J Neurol Neurosurg Psychiatry. (2005) 76:503–8. 10.1136/jnnp.2004.040436 PubMed DOI PMC

Martinková P, Drabinová A, Liaw YL, Sanders EA, McFarland JL, Price RM. Checking equity: why differential item functioning analysis should be a routine part of developing conceptual assessments. CBE Life Sci Educ. (2017) 16:rm2. 10.1187/cbe.16-10-0307 PubMed DOI PMC

Martinková P, Hladká A, PotuŽníková E. Is academic tracking related to gains in learning competence? Using propensity score matching and differential item change functioning analysis for better understanding of tracking implications. Learn Instruction. (2020) 66:101286. 10.1016/j.learninstruc.2019.101286 DOI

Martinková P, Freeman J, Drabinová A, Erosheva E, Cattaneo D, Jonsdottir J, et al. . Physiotherapeutic interventions in multiple sclerosis across Europe: Regions and other factors that matter. Mult Scler Relat Disord. (2018) 22:59–67. 10.1016/j.msard.2018.03.005 PubMed DOI

Takeuchi N, Izumi S-I. Rehabilitation with poststroke motor recovery: a review with a focus on neural plasticity. Stroke Res Treat. (2013) 2013:128641. 10.1155/2013/128641 PubMed DOI PMC

Straudi S, Basaglia N. Neuroplasticity-based technologies and interventions for restoring motor functions in multiple sclerosis. Adv Exp Med Biol. (2017) 958:171–85. 10.1007/978-3-319-47861-6_11 PubMed DOI

Rasová K, Bučková B, Prokopiusová T, Procházková M, Angel G, Marková M, et al. . A three-arm parallel-group exploratory trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive “facilitation and inhibition” physical therapy. Eur J Phys Rehabil Med. (2021) 6:889–899. 10.23736/S1973-9087.21.06701-0 PubMed DOI

Vaney C, Gattlen B, Lugon-Moulin V, Meichtry A, Hausammann R, Foinant D, et al. . Robotic-assisted step training (lokomat) not superior to equal intensity of over-ground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair. (2012) 26:212–21. 10.1177/1545968311425923 PubMed DOI

Matthews PM, Johansen-Berg H, Reddy H. Non-invasive mapping of brain functions and brain recovery: applying lessons from cognitive neuroscience to neurorehabilitation. Restor Neurol Neurosci. (2004) 22:245–60. PubMed

Johansson BB. Brain plasticity and stroke rehabilitation. Willis Lecture Stroke. (2000) 31:223–30. 10.1161/01.STR.31.1.223 PubMed DOI

Perkel JM. Visiting “noncodarnia”. Biotechniques. (2013) 54:301. 10.2144/000114037 PubMed DOI

Wolska M, Jarosz-Popek J, Junger E, Wicik Z, Porshoor T, Sharif L, et al. . Long non-coding RNAs as promising therapeutic approach in ischemic stroke: a comprehensive review. Mol Neurobiol. (2021) 58:1664–82. 10.1007/s12035-020-02206-8 PubMed DOI PMC

Ren W, Yang X. Pathophysiology of long non-coding RNAs in ischemic stroke. Front Mol Neurosci. (2018) 11:96. 10.3389/fnmol.2018.00096 PubMed DOI PMC

Caley DP, Pink RC, Trujillano D, Carter DR. Long noncoding RNAs, chromatin, and development. Sci World J. (2010) 10:90–102. 10.1100/tsw.2010.7 PubMed DOI PMC

Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, et al. . The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell. (2007) 128:977–89. 10.1016/j.cell.2007.01.034 PubMed DOI

Marcho C, Bevilacqua A, Tremblay KD, Mager J. Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation. Epigenetics Chromatin. (2015) 8:10. 10.1186/s13072-015-0003-y PubMed DOI PMC

O'Leary VB, Hain S, Maugg D, Smida J, Azimzadeh O, Tapio S, et al. . Long non-coding RNA PARTICLE bridges histone and DNA methylation. Sci Rep. (2017) 7:1790. 10.1038/s41598-017-01875-1 PubMed DOI PMC

O'Leary VB, Ovsepian SV, Carrascosa LG, Buske FA, Radulovic V, Niyazi M, et al. . PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation. Cell Rep. (2015) 11:474–85. 10.1016/j.celrep.2015.03.043 PubMed DOI

Williams T, Ngo LH, Wickramasinghe VO. Nuclear export of RNA: different sizes, shapes and functions. Semin Cell Dev Biol. (2018) 75:70–7. 10.1016/j.semcdb.2017.08.054 PubMed DOI

Clark BS, Blackshaw S. Understanding the role of lncRNAs in nervous system development. Adv Exp Med Biol. (2017) 1008:253–82. 10.1007/978-981-10-5203-3_9 PubMed DOI PMC

Bechara EG, Didiot MC, Melko M, Davidovic L, Bensaid M, Martin P, et al. . A novel function for fragile X mental retardation protein in translational activation. PLoS Biol. (2009) 7:e16. 10.1371/journal.pbio.1000016 PubMed DOI PMC

Castets M, Schaeffer C, Bechara E, Schenck A, Khandjian EW, Luche S, et al. . FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts. Hum Mol Genet. (2005) 14:835–44. 10.1093/hmg/ddi077 PubMed DOI

Xu Q, Deng F, Xing Z, Wu Z, Cen B, Xu S, et al. . Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia. Cell Death Dis. (2016) 7:e2173. 10.1038/cddis.2016.57 PubMed DOI PMC

Ye X, Zhou XJ, Zhang H. Exploring the role of autophagy-related gene 5 (ATG5) yields important insights into autophagy in autoimmune/autoinflammatory diseases. Front Immunol. (2018) 9:2334. 10.3389/fimmu.2018.02334 PubMed DOI PMC

Deng Y, Chen D, Gao F, Lv H, Zhang G, Sun X, et al. . Silencing of long non-coding RNA GAS5 suppresses neuron cell apoptosis and nerve injury in ischemic stroke through inhibiting DNMT3B-dependent MAP4K4 methylation. Transl Stroke Res. (2020) 11:950–66. 10.1007/s12975-019-00770-3 PubMed DOI

Enderby P, Pandyan A, Bowen A, Hearnden D, Ashburn A, Conroy P, et al. . Accessing rehabilitation after stroke - a guessing game? Disabil Rehabil. (2017) 39:709–13. 10.3109/09638288.2016.1160448 PubMed DOI

Alexander MP. Stroke rehabilitation outcome. A potential use of predictive variables to establish levels of care. Stroke. (1994) 25:128–34. 10.1161/01.STR.25.1.128 PubMed DOI

Shah S, Vanclay F, Cooper B. Efficiency, effectiveness, and duration of stroke rehabilitation. Stroke. (1990) 21:241–6. 10.1161/01.STR.21.2.241 PubMed DOI

Burton CR, Horne M, Woodward-Nutt K, Bowen A, Tyrrell P. What is rehabilitation potential? Development of a theoretical model through the accounts of healthcare professionals working in stroke rehabilitation services. Disabil Rehabil. (2015) 37:1955–60. 10.3109/09638288.2014.991454 PubMed DOI

Hu MH, Hsu SS, Yip PK, Jeng JS, Wang YH. Early and intensive rehabilitation predicts good functional outcomes in patients admitted to the stroke intensive care unit. Disabil Rehabil. (2010) 32:1251–9. 10.3109/09638280903464448 PubMed DOI

MZCR . Registrační List Ošetrovacího Dne Následné Komplexní Intenzivní RehabilitacNí LécBy U Pacientu Se Získaným PošKozením Mozku (Registration Sheet of the Treatment Day Following Comprehensive Intensive Rehabilitation Treatment for Patients With Acquired Brain Damage), REGISTRACNÍ LIST_OD_00033, kranioprogram_MZ CR, Praha, 2020. Praha: MZČR.

Feydy A, Carlier R, Roby-Brami A, Bussel B, Cazalis F, Pierot L, et al. . Longitudinal study of motor recovery after stroke: recruitment and focusing of brain activation. Stroke. (2002) 33:1610–7. 10.1161/01.STR.0000017100.68294.52 PubMed DOI

Turner-Stokes L. Cost-efficiency of longer-stay rehabilitation programmes: can they provide value for money? Brain Injury. (2007) 21:1015–21. 10.1080/02699050701591445 PubMed DOI

Malhotra S, Pandyan AD, Rosewilliam S, Roffe C, Hermens H. Spasticity and contractures at the wrist after stroke: time course of development and their association with functional recovery of the upper limb. Clin Rehabil. (2011) 25:184–91. 10.1177/0269215510381620 PubMed DOI

Chan A-W, Tetzlaff JM, Gøtzsche PC, Altman DG, Mann H, Berlin JA, et al. . SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. (2013) 346:e7586. 10.1136/bmj.e7586 PubMed DOI PMC

Grefkes C, Fink GR. Recovery from stroke: current concepts and future perspectives. Neurol Res Pract. (2020) 2:17. 10.1186/s42466-020-00060-6 PubMed DOI PMC

Bernhardt J, Hayward KS, Kwakkel G, Ward NS, Wolf SL, Borschmann K, et al. . Agreed definitions and a shared vision for new standards in stroke recovery research: the stroke recovery and rehabilitation roundtable taskforce. Int J Stroke. (2017) 12:444–50. 10.1177/1747493017711816 PubMed DOI

van Swieten J. Modified Rankin Scale for Neurologic Disability: MDCalc ©. (2021). Available online at: https://www.mdcalc.com/modified-rankin-scale-neurologic-disability#creator-insights (accessed October 22, 2022).

American Medical Association. Pre-Stroke Modified Rankin Score (mRS). (2020). Available online at: https://manual.jointcommission.org/releases/TJC2018A/DataElem0569.html (accessed October 22, 2022).

Lacas A, Rockwood K. Frailty in primary care: a review of its conceptualization and implications for practice. BMC Med. (2012) 10:4. 10.1186/1741-7015-10-4 PubMed DOI PMC

Ustün TB, Chatterji S, Kostanjsek N, Rehm J, Kennedy C, Epping-Jordan J. et al. Developing the world health organization disability assessment schedule 20. Bull World Health Organ. (2010) 88:815–23. 10.2471/BLT.09.067231 PubMed DOI PMC

Branch, IR . ICF e-Learning Tool. Available online at: https://www.icf-research-branch.org/icf-training/icf-e-learning-tool (accessed October 22, 2022).

Angerová Y . Advances in an Inter-Professional Approach to the Examination Rehabilitation of Patients After Brain Injury. (2022). Available online at: https://is.cuni.cz/studium/predmety/index.php?id=e7594df3f7abb1c314d7ca93ddce737f&tid=&do=predmet&kod=DS013 (accessed October 22, 2022).

Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. (1982) 14:377–81. 10.1249/00005768-198205000-00012 PubMed DOI

Bukowski L, Bonavolonta M, Keehn MT, Morgan KA. Interdisciplinary roles in stroke care. Nurs Clin North Am. (1986) 21:359–74. 10.1016/S0029-6465(22)00423-6 PubMed DOI

Yagura H, Miyai I, Suzuki T, Yanagihara T. Patients with severe stroke benefit most by interdisciplinary rehabilitation team approach. Cerebrovasc Dis. (2005) 20:258–63. 10.1159/000087708 PubMed DOI

Miller EL, Murray L, Richards L, Zorowitz RD, Bakas T, Clark P, et al. . Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American heart association. Stroke. (2010) 41:2402–48. 10.1161/STR.0b013e3181e7512b PubMed DOI

Geyh S, Cieza A, Schouten J, Dickson H, Frommelt P, Omar Z, et al. . ICF Core Sets for stroke. J Rehabil Med. (2004) 2004 (Suppl. 44):135–41. 10.1080/16501960410016776 PubMed DOI

Prodinger B, Reinhardt JD, Selb M, Stucki G, Yan T, Zhang X, et al. . Towards system-wide implementation of the international classification of functioning, disability and health (ICF) in routine practice: developing simple, intuitive descriptions of ICF categories in the ICF generic and rehabilitation set. J Rehabil Med. (2016) 48:508–14. 10.2340/16501977-2066 PubMed DOI

Reed GM, Lux JB, Bufka LF, Trask C, Peterson DB, Stark S, et al. . Operationalizing the international classification of functioning, disability and health in clinical settings. Rehabil Psychol. (2005) 2005:122–31. 10.1037/0090-5550.50.2.122 DOI

Tempest S, Harries P, Kilbride C, De Souza L. To adopt is to adapt: the process of implementing the ICF with an acute stroke multidisciplinary team in England. Disabil Rehabil. (2012) 34:1686–94. 10.3109/09638288.2012.658489 PubMed DOI PMC

Branch IR . The ICF Intervention Table. (2022). Available online at: https://www.icf-casestudies.org (accessed August 9, 2022).

Mehrholz J, Thomas S, Werner C, Kugler J, Pohl M, Elsner B. Electromechanical-assisted training for walking after stroke. Cochrane Database Syst Rev. (2017) 5:Cd006185. 10.1002/14651858.CD006185.pub4 PubMed DOI PMC

Su F, Xu W. Enhancing brain plasticity to promote stroke recovery. Front Neurol. (2020) 11:554089. 10.3389/fneur.2020.554089 PubMed DOI PMC

Epple C, Maurer-Burkhard B, Lichti M-C, Steiner T. Vojta therapy improves postural control in very early stroke rehabilitation: a randomised controlled pilot trial. Neurol Res Pract. (2020) 2:23. 10.1186/s42466-020-00070-4 PubMed DOI PMC

Gunning E, Uszynski MK. Effectiveness of the proprioceptive neuromuscular facilitation method on gait parameters in patients with stroke: a systematic review. Arch Phys Med Rehabil. (2019) 100:980–6. 10.1016/j.apmr.2018.11.020 PubMed DOI

Rasova K, Prochazkova M, Tintera J, Ibrahim I, Zimova D, Stetkarova I. Motor programme activating therapy influences adaptive brain functions in multiple sclerosis: clinical and MRI study. Int J Rehabil Res. (2015) 38:49–54. 10.1097/MRR.0000000000000090 PubMed DOI

Rasová K, Martinková P, Soler B, Freeman J, Cattaneo D, Jonsdottir J, et al. . Real-world goal setting and use of outcome measures according to the international classification of functioning, disability and health: a european survey of physical therapy practice in multiple sclerosis. Int J Environ Res Public Health. (2020) 17:4774. 10.3390/ijerph17134774 PubMed DOI PMC

Haigh R, Tennant A, Biering-Sorensen F, Grimby G, Marincek C, Phillips S, et al. . The use of outcome measures in physical medicine and rehabilitation within Europe. J Rehabil Med. (2001) 33:273–8. 10.1080/165019701753236464 PubMed DOI

Havlík J, Horák P, Rasová K, Rezníčková J, Zeman J. The evaluation of the tremor: signal database of healthy control subjects. Praha: IFMBE Proceedings; (2018).

Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. (1971) 9:97–113. 10.1016/0028-3932(71)90067-4 PubMed DOI

Costa PT, McCrae RR. Revised NEO Personality Inventory (NEO-PIR) and NEO Five Factor Inventory (NEO-FFI) Professional Manual. Odessa, FL: Psychological Assessment Resources; (1992).

Wilson JT, Hareendran A, Grant M, Baird T, Schulz UG, Muir KW, et al. . Improving the assessment of outcomes in stroke: use of a structured interview to assign grades on the modified rankin scale. Stroke. (2002) 33:2243–6. 10.1161/01.STR.0000027437.22450.BD PubMed DOI

Mediano MFF, Mok Y, Coresh J, Kucharska-Newton A, Palta P, Lakshminarayan K, et al. . Prestroke physical activity and adverse health outcomes after stroke in the atherosclerosis risk in communities study. Stroke. (2021) 52:2086–95. 10.1161/STROKEAHA.120.032695 PubMed DOI PMC

Lyden P, Raman R, Liu L, Emr M, Warren M, Marler J. National institutes of health stroke scale certification is reliable across multiple venues. Stroke. (2009) 40:2507–11. 10.1161/STROKEAHA.108.532069 PubMed DOI PMC

Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. (1991) 337:1521–6. 10.1016/0140-6736(91)93206-O PubMed DOI

Reeves M, Lisabeth L, Williams L, Katzan I, Kapral M, Deutsch A, et al. . Patient-reported outcome measures (PROMs) for acute stroke: rationale, methods and future directions. Stroke. (2018) 49:1549–56. 10.1161/STROKEAHA.117.018912 PubMed DOI

Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res. (2009) 18:873–80. 10.1007/s11136-009-9496-9 PubMed DOI PMC

Ustun TB Kostanjesek N Chatterji S Rehm J World Health Organisation . Measuring health and disability: manual for WHO disability assessment schedule (WHODAS 2.0). In: Üstiün TB, Kostanjsek N, Chatterji S, Rehm J. Geneva: World Health Organization (2010). Available online at: https://apps.who.int/iris/handle/10665/43974

Ottenbacher KJ, Cusick A. Goal attainment scaling as a method of clinical service evaluation. Am J Occup Ther. (1990) 44:519–25. 10.5014/ajot.44.6.519 PubMed DOI

Turner-Stokes L, Williams H, Johnson J. Goal attainment scaling: does it provide added value as a person-centred measure for evaluation of outcome in neurorehabilitation following acquired brain injury? J Rehabil Med. (2009) 41:528–35. 10.2340/16501977-0383 PubMed DOI

Bertrand AM, Mercier C, Bourbonnais D, Desrosiers J, Gravel D. Reliability of maximal static strength measurements of the arms in subjects with hemiparesis. Clin Rehabil. (2007) 21:248–57. 10.1177/0269215506070792 PubMed DOI

Chen HM, Chen CC, Hsueh IP, Huang SL, Hsieh CL. Test-retest reproducibility and smallest real difference of 5 hand function tests in patients with stroke. Neurorehabil Neural Repair. (2009) 23:435–40. 10.1177/1545968308331146 PubMed DOI

Chen HF, Lin KC, Wu CY, Chen CL. Rasch validation and predictive validity of the action research arm test in patients receiving stroke rehabilitation. Arch Phys Med Rehabil. (2012) 93:1039–45. 10.1016/j.apmr.2011.11.033 PubMed DOI

Uswatte G, Taub E, Morris D, Vignolo M, McCulloch K. Reliability and validity of the upper-extremity motor activity log-14 for measuring real-world arm use. Stroke. (2005) 36:2493–6. 10.1161/01.STR.0000185928.90848.2e PubMed DOI

Persson CU, Danielsson A, Sunnerhagen KS, Grimby-Ekman A, Hansson PO. Timed up & go as a measure for longitudinal change in mobility after stroke - postural stroke study in gothenburg (POSTGOT). J Neuroeng Rehabil. (2014) 11:83. 10.1186/1743-0003-11-83 PubMed DOI PMC

Blum L, Korner-Bitensky N. Usefulness of the berg balance scale in stroke rehabilitation: a systematic review. Phys Ther. (2008) 88:559–66. 10.2522/ptj.20070205 PubMed DOI

Cheng DK, Nelson M, Brooks D, Salbach NM. Validation of stroke-specific protocols for the 10-meter walk test and 6-minute walk test conducted using 15-meter and 30-meter walkways. Top Stroke Rehabil. (2020) 27:251–61. 10.1080/10749357.2019.1691815 PubMed DOI

Ring H, Feder M, Schwartz J, Samuels G. Functional measures of first-stroke rehabilitation inpatients: usefulness of the functional independence measure total score with a clinical rationale. Arch Phys Med Rehabil. (1997) 78:630–5. 10.1016/S0003-9993(97)90429-9 PubMed DOI

Kostalova M, Mrackova M, Marecek R, Berankova D, Eliasova I, Janousova E, et al. . The 3F test dysarthric profile—normative speach values in Czech. Cesk Slov Neurol Neurochir. (2013) 76:614–18.

Rusz J, Tykalova T, Ramig LO, Tripoliti E. Guidelines for speech recording and acoustic analyses in dysarthrias of movement disorders. Mov Disord. (2021) 36:803–14. 10.1002/mds.28465 PubMed DOI

Nakase-Thompson R, Manning E, Sherer M, Yablon SA, Gontkovsky SL, Vickery C. Brief assessment of severe language impairments: initial validation of the mississippi aphasia screening test. Brain Injury. (2005) 19:685–91. 10.1080/02699050400025331 PubMed DOI

Štenová V, Cséfalvay Z. Test Pomenovania Obrázkov. Bratislava: SAL; (2011).

Jaywant A, Toglia J, Gunning FM, O'Dell MW. Subgroups defined by the montreal cognitive assessment differ in functional gain during acute inpatient stroke rehabilitation. Arch Phys Med Rehabil. (2020) 101:220–6. 10.1016/j.apmr.2019.08.474 PubMed DOI PMC

Bartos A, Fayette D. Validation of the czech montreal cognitive assessment for mild cognitive impairment due to Alzheimer disease and czech norms in 1,552 elderly persons. Dement Geriatr Cogn Disord. (2018) 46:335–45. 10.1159/000494489 PubMed DOI

Bartoš A. Two original Czech tests for memory evaluation in three minutes – amnesia light and brief assessment (ALBA) [article in Czech: Dvě pu°vodní české zkoušky k vyšetrení paměti za tři minuty - Amnesia Light and Brief Assessment (ALBA)]. Cesk Slov Neurol N. (2019) 82:420–9. 10.14735/amcsnn2019420 DOI

Bartoš A, Diondet S. Amnesia light and brief assessment (ALBA) test – the second version and repeated examinations. [article in Czech: Test Amnesia Light and Brief Assessment (ALBA) – druhá verze a opakovaná vyšetrení]. Cesk Slov Neurol N. (2020) 83:535–43. 10.14735/amcsnn2020535 DOI

Bartoš A. Do not test but POBAV (ENTERTAIN) – written intentional naming of pictures and their recall as a brief cognitive test [article in Czech: Netestuj, ale POBAV: písemné záměrné Pojmenování OBrázku A jejich Vybavení jako krátká kognitivní zkouška]. Cesk Slov Neurol N. (2016) 79:671–9. Available online at: https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2016-6-4/netestuj-ale-pobav-pisemne-zamerne-pojmenovani-obrazku-a-jejich-vybaveni-jako-kratka-kognitivni-zkouska-59479

Cella D, Lai JS, Nowinski CJ, Victorson D, Peterman A, Miller D, et al. . Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology. Neurology. (2012) 78:1860–7. 10.1212/WNL.0b013e318258f744 PubMed DOI PMC

Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res. (2001) 125:279–84. 10.1016/S0166-4328(01)00297-2 PubMed DOI

Team RC. A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; (2021).

Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. (2015) 67:1–48. 10.18637/jss.v067.i01 DOI

Pinheiro JBD, DebRoy S, Sarkar D. R Core Team. _nlme: Linear Nonlinear Mixed Effects Models_. R package version 3.1-152. (2021). Available online at: https://CRAN.R-project.org/package=nlme> (accessed May 30, 2022).

Hladká A, Martinková P. difNLR: generalized logistic regression models for DIF and DDF detection. R J. (2020) 12:300–23. 10.32614/RJ-2020-014 DOI

Martinková P, Drabinová A. Shinyitemanalysis for teaching psychometrics and to enforce routine analysis of educational tests. R J. (2018) 10:503–15. 10.32614/RJ-2018-074 DOI

Improvements in upper extremity isometric muscle strength, dexterity, and self-care independence during the sub-acute phase of stroke recovery: an observational study on the effects of intensive comprehensive rehabilitation

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