The cornea and the skin are two organs that form the outer barrier of the human body. When either is injured (e.g., from surgery, physical trauma, or chemical burns), wound healing is initiated to restore integrity. Many cells are activated during wound healing. In particular, fibroblasts that are stimulated often transition into repair fibroblasts or myofibroblasts that synthesize extracellular matrix (ECM) components into the wound area. Control of wound ECM deposition is critical, as a disorganized ECM can block restoration of function. One of the most abundant structural proteins in the mammalian ECM is collagen. Collagen type I is the main component in connective tissues. It can be readily obtained and purified, and short analogs have also been developed for tissue engineering applications, including modulating the wound healing response. This review discusses the effect of several current collagen implants on the stimulation of corneal and skin wound healing. These range from collagen sponges and hydrogels to films and membranes.

Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palacký University in Olomouc 775 15 Olomouc Czech Republic

Department of Ophthalmology Université de Montréal Montréal QC H3C 3J7 Canada

Maisonneuve Rosemont Hospital Research Centre Montréal QC H1T 2M4 Canada

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Materials Suitable for Osteochondral Regeneration