The Current Status and Work of Three Rs Centres and Platforms in Europe

. 2022 Nov ; 50 (6) : 381-413.

Jazyk angličtina Země Anglie, Velká Británie Médium print

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid36458800

The adoption of Directive 2010/63/EU on the protection of animals used for scientific purposes has given a major push to the formation of Three Rs initiatives in the form of centres and platforms. These centres and platforms are dedicated to the so-called Three Rs, which are the Replacement, Reduction and Refinement of animal use in experiments. ATLA's 50th Anniversary year has seen the publication of two articles on European Three Rs centres and platforms. The first of these was about the progressive rise in their numbers and about their founding history; this second part focuses on their current status and activities. This article takes a closer look at their financial and organisational structures, describes their Three Rs focus and core activities (dissemination, education, implementation, scientific quality/translatability, ethics), and presents their areas of responsibility and projects in detail. This overview of the work and diverse structures of the Three Rs centres and platforms is not only intended to bring them closer to the reader, but also to provide role models and show examples of how such Three Rs centres and platforms could be made sustainable. The Three Rs centres and platforms are very important focal points and play an immense role as facilitators of Directive 2010/63/EU 'on the ground' in their respective countries. They are also invaluable for the wide dissemination of information and for promoting the implementation of the Three Rs in general.

Applied Radiation Therapy Trinity School of Medicine 8809Trinity College Dublin College Green Dublin Ireland

Biomedical Research 31475Medical University Graz Austria

Bioresearch and Veterinary Services The University of Edinburgh Edinburgh UK

Center for Alternatives to Animal Testing Europe University of Konstanz Germany

Centre of Toxicology and Health Safety 37739National Institute of Public Health Prague Czech Republic

Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt Universität zu Berlin Charité3R Berlin Germany

Comparative Medicine and Bioimage Centre of Catalonia Badalona Spain

Comparative Medicine Unit 8809Trinity College Dublin College Green Dublin Ireland

Core Facility Preclinical Models Universitätsmedizin Mannheim Medical Faculty Mannheim University of Heidelberg Mannheim Germany

Danmarks 3R Center Glostrup Denmark

Department of Biomedical Research 27271Medical University of Vienna Austria

Department of Information Engineering Università di Pisa and Centro 3R Interuniversity Centre for the Promotion of 3Rs Principles in Teaching and Research Italy

Department of Mechanical and Aerospace Engineering 19032Politecnico di Torino Torino and Centro 3R and Interuniversity Center for the Promotion of 3Rs Principles in Teaching and Research Italy

EUSAAT 31189Austrian Institute of Technology GmbH Competence Unit Molecular Diagnostics Centre for Health and Bioresources Vienna Austria and Danube Private University Department of Medicine Krems Austria

Freie Universität Berlin Department of Veterinary Medicine Institute of Animal Welfare Animal Behaviour and Laboratory Animal Science Berlin Germany

Freie Universität Berlin Institute of Pharmacy Pharmacology and Toxicology Berlin Germany

i3S Instituto de Investigação e Inovação em Saúde 26706Universidade do Porto Porto Portugal

IBMC Instituto de Biologia Molecular e Celular 26706Universidade do Porto Porto Portugal

Institute for Laboratory Animal Science 9177Hannover Medical School Hannover Germany

Institute of Hygiene and Medical Microbiology Medical University of Innsbruck Austria

Institute of Psychopharmacology Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Heidelberg Germany

Interfaculty Biomedical Research Facility University Heidelberg Heidelberg Germany

IUF Leibniz Research Institute for Environmental Medicine Düsseldorf Germany

Laboratory for Biological Characterisation of Advanced Materials School of Medicine 8809Trinity College Dublin College Green Dublin Ireland

Luxembourg Institute of Science and Technology Belvaux Luxembourg

Medical Faculty Heinrich Heine University Düsseldorf Germany

Ministry of Agriculture Nature and Food Quality The Hague The Netherlands

National Centre for the 3Rs London United Kingdom

National Institute for Public Health and the Environment RIVM BA Bilthoven The Netherlands

Netherlands National Committee for the protection of animals used for scientific purposes The Hague The Netherlands

Norecopa Ås Norway

QSAR Lab Ltd Gdańsk Poland

R Centre JLU Giessen Interdisciplinary Centre for 3Rs in Animal Research Giessen Germany

Romanian Center for Alternative Test Methods hosted by the 162275University of Agricultural Sciences and Veterinary Medicine in Cluj Napoca Romania

Rs Centre Department of Population Health Sciences Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands

Slovak National Platform for 3Rs SNP3Rs Bratislava Slovakia; and Department of Tissue Cultures and Biochemical Engineering Institute of Experimental Pharmacology and Toxicology Centre of Experimental Medicine SAS 87171Slovak Academy of Sciences Bratislava Slovakia

Swedish 3Rs Center Swedish Board of Agriculture Jönköping Sweden

Swiss 3RCC Bern Switzerland

TARC force 3R Translational Animal Research Center University Medical Centre Johannes Gutenberg University Mainz Germany

The National Centre for Alternative Methods to Toxicity Assessment 49611Nofer Institute of Occupational Medicine Łódź Poland

Translational Animal Research Center University Medical Centre Johannes Gutenberg University Mainz Germany

University of Luxembourg Esch sur Alzette Luxembourg

University of Veterinary Medicine Hannover Department of Biochemistry and Research Centre for Emerging Infections and Zoonoses Hannover Germany

University of Veterinary Medicine Hannover Institute for Food Quality and Food Safety Research Group Food Toxicology and Alternatives Complementary Methods to Animal Experiments Hannover Germany

Vrije Universiteit Brussel Brussels Belgium

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