In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community believes that the infrastructure aspects of systems biology - databases, (modelling) tools and standards development, as well as training and access to cloud infrastructure - are not only appropriate components of the ELIXIR infrastructure, but will prove key components of ELIXIR's future support of advanced biological applications and personalised medicine. By way of a series of meetings, the Community identified seven key areas for its future activities, reflecting both future needs and previous and current activities within ELIXIR Platforms and Communities. These are: overcoming barriers to the wider uptake of systems biology; linking new and existing data to systems biology models; interoperability of systems biology resources; further development and embedding of systems medicine; provisioning of modelling as a service; building and coordinating capacity building and training resources; and supporting industrial embedding of systems biology. A set of objectives for the Community has been identified under four main headline areas: Standardisation and Interoperability, Technology, Capacity Building and Training, and Industrial Embedding. These are grouped into short-term (3-year), mid-term (6-year) and long-term (10-year) objectives.

BIO3 Laboratory for Systems Medicine Department of Human Genetics KU Leuven Leuven 3000 Belgium

BIO3 Systems Genetics GIGA R Medical Genomics University of Liege Liege 4000 Belgium

Centre of Biological Engineering University of Minho Braga Portugal

Competence Center for Methodology and Statistics; Transversal Translational Medicine Translational Medicine Operations Hub Luxembourg Institute of Health Strassen L 1445 Luxembourg

Department of Bioinformatics BiGCaT NUTRIM Maastricht University Maastricht 6200 MD The Netherlands

Department of Bioinformatics Maastricht University Maastricht The Netherlands

Department of Biology and Biological Engineering National Bioinformatics Infrastructure Sweden Science for Life Laboratory Chalmers University of Technology Gothenburg SE 41258 Sweden

Department of Biotechnology and Systems Biology National Institute of Biology Ljubljana SI 1000 Slovenia

Department of Computer Science The University of Manchester Manchester M13 9PL UK

Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK

ELIXIR Hub Hinxton Cambridge CB10 1SD UK

European Molecular Biology Laboratory European Bioinformatics Institute Hinxton Cambridge CB10 1SD UK

Faculty of Informatics Masaryk University Brno 602 00 Czech Republic

Faculty of Medicine Institute for Biostatistics and Medical Informatics Centre ELIXIR SI University of Ljubljana Ljubljana SI 1000 Slovenia

Faculty of Medicine University of Ljubljana Ljubljana SI 1000 Slovenia

Heidelberg Institute for Theoretical Studies HITS Heidelberg 69118 Germany

ISBE NL VU University of Amsterdam Amsterdam The Netherlands

Laboratory of Bioprocess Engineering Wageningen University and Research Wageningen 6708 PB The Netherlands

Laboratory of Systems and Synthetic Biology Wageningen University and Research Wageningen 6708WE The Netherlands

Leiden Institute of Advanced Computer Science Leiden University Leiden 2333 CA The Netherlands

Luxembourg Centre for Systems Biomedicine University of Luxembourg Belvaux L 4367 Luxembourg

Maastricht Centre for Systems Biology Maastricht University Maastricht 6200 MD The Netherlands

Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering Sciences Foundation for Research and Technology Hellas Patras 26504 Greece

National Bioinformatics Infrastructure Sweden Science for Life Laboratory Department of Biochemistry and Biophysics Stockholm University Stockholm Sweden

Research and Platforms Department Genopole Evry Courcouronnes 91030 France

Scientific Network Management SL Barcelona 08015 Spain

SIB Swiss Institute of Bioinformatics Lausanne Switzerland

Systems Biology Ireland School of Medicine University College Dublin Dublin 4 Ireland

UNLOCK Wageningen University and Research 6708 PB Wageningen The Netherlands

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Making PBPK models more reproducible in practice