Bystander activation in memory and antigen-inexperienced memory-like CD8 T cells
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
36913776
DOI
10.1016/j.coi.2023.102299
PII: S0952-7915(23)00018-3
Knihovny.cz E-zdroje
- Klíčová slova
- CD8, CD8+ T cells, IFNγ, IL-12, Memory T cells, NKG2D, antigen-inexperienced memory-like T cells, bystander response, innate-like lymphocytes,
- MeSH
- aktivace lymfocytů * MeSH
- antigeny MeSH
- CD8-pozitivní T-lymfocyty * MeSH
- cytokiny MeSH
- imunologická paměť MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antigeny MeSH
- cytokiny MeSH
Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFNγ and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.
Citace poskytuje Crossref.org
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