Faculty of Sciences University of South Bohemia České Budějovice Czech Republic

Institute of Microbiology Czech Academy of Sciences Prague Czech Republic

Institute of Parasitology Biology Centre Czech Academy of Sciences České Budějovice Czech Republic

Zobrazit více v PubMed

Brenner S, Jacob F, Meselson M. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature. 1961;190:576‐581. doi:10.1038/190576a0 PubMed DOI

Nirenberg M, Leder P. RNA codewords and protein synthesis. The effect of trinucleotides upon the binding of sRNA to ribosomes. Science. 1964;145:1399‐1407. doi:10.1126/science.145.3639.1399 PubMed DOI

Shulgina Y, Eddy SR. A computational screen for alternative genetic codes in over 250,000 genomes. Elife. 2021;10:e71402. doi:10.7554/eLife.71402 PubMed DOI PMC

Swart EC, Serra V, Petroni G, Nowacki M. Genetic codes with no dedicated stop codon: context‐dependent translation termination. Cell. 2016;166:691‐702. doi:10.1016/j.cell.2016.06.020 PubMed DOI PMC

Heaphy SM, Mariotti M, Gladyshev VN, Atkins JF, Baranov PV. Novel ciliate genetic code variants including the reassignment of all three stop codons to sense codons in Condylostoma magnum . Mol Biol Evol. 2016;33:2885‐2889. doi:10.1093/molbev/msw166 PubMed DOI PMC

Záhonová K, Kostygov AY, Ševčíková T, Yurchenko V, Eliáš M. An unprecedented non‐canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr Biol. 2016;26:2364‐2369. doi:10.1016/j.cub.2016.06.064 PubMed DOI

Kachale A, Pavlíková Z, Nenarokova A, et al. Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature. 2023;613:751‐758. doi:10.1038/s41586-022-05584-2 PubMed DOI

Keeling KM, Xue X, Gunn G, Bedwell DM. Therapeutics based on stop codon readthrough. Annu Rev Genomics Hum Genet. 2014;15:371‐394. PubMed PMC

Lee H‐LR, Dougherty JP. Pharmaceutical therapies to recode nonsense mutations in inherited diseases. Pharmacol Ther. 2012;136:227‐266. doi:10.1016/j.pharmthera.2012.07.007 PubMed DOI

Wagner RN, Wießner M, Friedrich A, Zandanell J, Breitenbach‐Koller H, Bauer JW. Emerging personalized opportunities for enhancing translational readthrough in rare genetic diseases and beyond. Int J Mol Sci. 2023;24:6101. doi:10.3390/ijms24076101 PubMed DOI PMC

Konstan MW, Vandevanter DR, Rowe SM, et al. Efficacy and safety of ataluren in patients with nonsense‐mutation cystic fibrosis not receiving chronic inhaled aminoglycosides: The international, randomized, double‐blind, placebo‐controlled Ataluren Confirmatory Trial in Cystic Fibrosis (ACT CF). J Cyst Fibros. 2020;19:595‐601. doi:10.1016/j.jcf.2020.01.007 PubMed DOI PMC

Beznosková P, Bidou L, Namy O, Valášek LS. Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines. Nucleic Acids Res. 2021;49:5202‐5215. doi:10.1093/nar/gkab315 PubMed DOI PMC

Koukuntla R, Ramsey WJ, Young W‐B, Link CJ. U6 promoter‐enhanced GlnUAG suppressor tRNA has higher suppression efficacy and can be stably expressed in 293 cells. J Gene Med. 2013;15:93‐101. doi:10.1002/jgm.2696 PubMed DOI

Wang J, Zhang Y, Mendonca CA, et al. AAV‐delivered suppressor tRNA overcomes a nonsense mutation in mice. Nature, 2022;604:343‐348. doi:10.1038/s41586-022-04533-3 PubMed DOI PMC

Shi N, Yang Qi, Zhang H, et al. Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids. Nat Biomed Eng. 2022;6:195‐206. doi:10.1038/s41551-021-00774-1 PubMed DOI

Lueck JD, Yoon JS, Perales‐Puchalt A, et al. Engineered transfer RNAs for suppression of premature termination codons. Nat Commun. 2019;10:822. doi:10.1038/s41467-019-08329-4 PubMed DOI PMC

Albers S, Beckert B, Matthies MC, et al. Repurposing tRNAs for nonsense suppression. Nat Commun. 2021;12:3850. doi:10.1038/s41467-021-24076-x PubMed DOI PMC

Huang L, Aghajan M, Quesenberry T, et al. Targeting translation termination machinery with antisense oligonucleotides for diseases caused by nonsense mutations. Nucleic Acid Ther. 2019;29:175‐186. doi:10.1089/nat.2019.0779 PubMed DOI PMC

Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough

Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment