The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
37449750
PubMed Central
PMC10668997
DOI
10.33549/physiolres.935091
PII: 935091
Knihovny.cz E-zdroje
- MeSH
- analgetika metabolismus MeSH
- játra metabolismus MeSH
- krysa rodu Rattus MeSH
- lékové postižení jater * etiologie prevence a kontrola metabolismus MeSH
- oxidační stres MeSH
- oxidancia MeSH
- paracetamol * toxicita MeSH
- potkani Wistar MeSH
- sirtuin 1 metabolismus MeSH
- vaskulární endoteliální růstový faktor A metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- analgetika MeSH
- oxidancia MeSH
- paracetamol * MeSH
- sirtuin 1 MeSH
- vaskulární endoteliální růstový faktor A MeSH
Regular physical exercise is beneficial to the body. Acute exercise causes oxidant stress in many tissues including the liver by creating an unbalanced status between oxidant and antioxidant levels. Analgesic drugs are commonly consumed to reduce the pain after exercise. Acetaminophen (APAP), commonly used as an over-the-counter analgesic, can cause hepatotoxicity. The aim of this study was to investigate the effect and underlying mechanisms of APAP at subtoxic dose, which is given after the acute and exhaustive exercise on the rat livers. Male Wistar rats weighing 200-250 g were divided into 6 groups each consisting of 7 rats/group; Control, APAP (250 mg/kg, ip), Acute Exercise (AEx), Acute Exhaustive Exercise (AEEx), Acute Exercise and APAP (AEx+APAP) and Acute Exhaustive Exercise and APAP (AEEx+APAP) groups. Rats were exercised at moderate intensity or exhaustive on the treadmill and then received APAP. Tissue MDA levels were significantly increased in AEEx, AEx+APAP and AEEx+APAP groups compared with the control. There was no significant difference in GSH levels between groups. Tissue Sirtuin1 (Sirt1) levels of APAP, AEx and AEEx groups were significantly less than control. There was no significant difference between groups in VEGF levels. Liver damage score was significantly higher in all groups compared with control group. As a result, this study shows that subtoxic dose of APAP treatment alone or in combination with acute or exhaustive treadmill exercise can cause oxidative liver damage by affecting Sirt1 levels and without affecting VEGF levels.
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