Department of Chemistry Organic Chemistry 3 Bielefeld University Bielefeld Germany

Institute of Microbiology of the Czech Academy of Sciences v v i Prague Czechia

The Bartholin Institute Department of Pathology Rigshospitalet Copenhagen Denmark

Translational Type 1 Diabetes Research Clinical Research Steno Diabetes Center Copenhagen Herlev Denmark

Editorial on the Research Topic The gut-pancreas axis in type 1 diabetes – a focus on environmental factors PubMed

Zobrazit více v PubMed

Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GV, et al. . The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet (2004) 364:1699–700. doi: 10.1016/S0140-6736(04)17357-1 PubMed DOI

Neuman V, Pruhova S, Kulich M, Kolouskova S, Vosahlo J, Romanova M, et al. . Gluten-free diet in children with recent-onset type 1 diabetes: A 12-month intervention trial. Diabetes Obes Metab (2020) 22:866–72. doi: 10.1111/dom.13974 PubMed DOI

Carre A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R. Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention. Endocr Rev (2023) 44:737–51. doi: 10.1210/endrev/bnad007 PubMed DOI

Bruun SW, Josefsen K, Tanassi JT, Marek A, Pedersen MH, Sidenius U, et al. . Large gliadin peptides detected in the pancreas of NOD and healthy mice following oral administration. J Diabetes Res (2016) 2016:2424306. doi: 10.1155/2016/2424306 PubMed DOI PMC

Bosi E, Molteni L, Radaelli MG, Folini L, Fermo I, Bazzigaluppi E, et al. . Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia (2006) 49:2824–7. doi: 10.1007/s00125-006-0465-3 PubMed DOI

Hanninen A, Toivonen R, Poysti S, Belzer C, Plovier H, Ouwerkerk JP, et al. . Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice. Gut (2018) 67:1445–53. doi: 10.1136/gutjnl-2017-314508 PubMed DOI

Funda DP, Kaas A, Bock T, Tlaskalova-Hogenova H, Buschard K. Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev (1999) 15:323–7. doi: 10.1002/(sici)1520-7560(199909/10)15:5<323::aid-dmrr53>3.0.co;2-p PubMed DOI

Pastore MR, Bazzigaluppi E, Belloni C, Arcovio C, Bonifacio E, Bosi E. Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes. J Clin Endocrinol Metab (2003) 88:162–5. doi: 10.1210/jc.2002-021177 PubMed DOI

Fuchtenbusch M, Ziegler AG, Hummel M. Elimination of dietary gluten and development of type 1 diabetes in high risk subjects. Rev Diabetes Stud (2004) 1:39–41. doi: 10.1900/RDS.2004.1.39 PubMed DOI PMC

Svensson J, Sildorf SM, Pipper CB, Kyvsgaard JN, Bojstrup J, Pociot FM, et al. . Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study. Springerplus (2016) 5:994. doi: 10.1186/s40064-016-2641-3 PubMed DOI PMC

Abdellatif AM, Sarvetnick NE. Current understanding of the role of gut dysbiosis in type 1 diabetes. J Diabetes (2019) 11:632–44. doi: 10.1111/1753-0407.12915 PubMed DOI

Roager HM, Licht TR. Microbial tryptophan catabolites in health and disease. Nat Commun (2018) 9:3294. doi: 10.1038/s41467-018-05470-4 PubMed DOI PMC

Dong F, Hao F, Murray IA, Smith PB, Koo I, Tindall AM, et al. . Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity. Gut Microbes (2020) 12:1–24. doi: 10.1080/19490976.2020.1788899 PubMed DOI PMC

Monteleone I, Rizzo A, Sarra M, Sica G, Sileri P, Biancone L, et al. . Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology (2011) 141:237–248, 248 e231. doi: 10.1053/j.gastro.2011.04.007 PubMed DOI

Krogvold L, Genoni A, Puggioni A, Campani D, Richardson SJ, Flaxman CS, et al. . Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study. Diabetologia (2022) 65:2108–20. doi: 10.1007/s00125-022-05779-2 PubMed DOI PMC

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, et al. . Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes (2015) 64:1682–7. doi: 10.2337/db14-1370 PubMed DOI

Pozzilli P, Bosi E, Cirkel D, Harris J, Leech N, Tinahones FJ, et al. . Randomized 52-week phase 2 trial of albiglutide versus placebo in adult patients with newly diagnosed type 1 diabetes. J Clin Endocrinol Metab (2020) 105:e2192–e2206. doi: 10.1210/clinem/dgaa149 PubMed DOI

Herold KC, Reynolds J, Dziura J, Baidal D, Gaglia J, Gitelman SE, et al. . Exenatide extended release in patients with type 1 diabetes with and without residual insulin production. Diabetes Obes Metab (2020) 22:2045–54. doi: 10.1111/dom.14121 PubMed DOI PMC

Edwards K, Li X, Lingvay I. Clinical and safety outcomes with GLP-1 receptor agonists and SGLT2 inhibitors in type 1 diabetes: A real-world study. J Clin Endocrinol Metab (2023) 108:920–30. doi: 10.1210/clinem/dgac618 PubMed DOI

McLeod KH, Mason L, Marino E. Transplantation of fecal microbiota shaped by diet. Bio Protoc (2018) 8:e2683. doi: 10.21769/BioProtoc.2683 PubMed DOI PMC

Funsten MC, Yurkovetskiy LA, Kuznetsov A, Reiman D, Hansen CHF, Senter KI, et al. . Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes. Cell Host Microbe (2023) 31:213–227 e219. doi: 10.1016/j.chom.2022.12.009 PubMed DOI PMC

Tlaskalova-Hogenova H, Stepankova R, Tuckova L, Farre MA, Funda DP, Verdu EF, et al. . Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora. Folia Microbiol (Praha) (1998) 43:545–50. doi: 10.1007/BF02820817 PubMed DOI