Trypanosomes as a magnifying glass for cell and molecular biology
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, přehledy
Grantová podpora
R01 GM084065
NIGMS NIH HHS - United States
PubMed
37679284
DOI
10.1016/j.pt.2023.08.004
PII: S1471-4922(23)00195-2
Knihovny.cz E-zdroje
- Klíčová slova
- GPI-anchor, RNA editing, alternative oxidase, endocytosis, genetic code, glycosome, tRNA import,
- MeSH
- molekulární biologie MeSH
- Trypanosoma brucei brucei * genetika MeSH
- Trypanosoma * genetika MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent development of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that have widely informed molecular and cellular biology and justifies continuing research as an experimental model. Ongoing work continues to contribute towards greater understanding of both diversified and conserved biological features. We discuss multiple examples where trypanosomes pushed the boundaries of cell biology and hope to inspire researchers to continue exploring these remarkable protists as tools for magnifying the inner workings of cells.
Department of Molecular Biology Cell Biology and Biochemistry Brown University Providence RI USA
Institute of Parasitology Biology Centre Czech Academy of Sciences České Budějovice Czech Republic
Medical Biochemistry University of Amsterdam AMC Amsterdam The Netherlands
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