Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

Department of Biomolecular Sciences Faculty of Biochemistry Weizmann Institute of Science Rehovot Israel

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Science Prague Czech Republic

Citace poskytuje Crossref.org

Spectral flow cytometry for detecting DNA cargo in malaria parasite-derived extracellular vesicles