Study of the anti-inflammatory properties of a thick extract of Tribulus terrestris L
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
37805264
PII: 135338
Knihovny.cz E-resources
- Keywords
- Tribulus terrestris, anti-inflammatory effect, corvitin, diclofenac sodium, thick extract,
- MeSH
- Anti-Inflammatory Agents pharmacology MeSH
- Carrageenan MeSH
- Rats MeSH
- Humans MeSH
- Prostatitis * MeSH
- Plant Extracts pharmacology MeSH
- Tribulus * MeSH
- Inflammation MeSH
- Animals MeSH
- Zymosan MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Carrageenan MeSH
- Plant Extracts MeSH
- Zymosan MeSH
The most promising direction in the treatment of chronic prostatitis is the use of medicinal plants and preparations based on them, which contain natural compounds with a broad spectrum of pharmacological activity: anti-inflammatory, antimicrobial, reparative, immunomodulatory, hormone-regulating, antisclerotic, etc., and which can provide a complex therapeutic effect on the course of chronic prostatitis. A promising raw material in this direction is Tribulus terrestris L., a herbal preparation traditionally used to treat erectile dysfunction and atherosclerosis. This experimental work aims to study the anti-inflammatory activity of a thick extract of the Tribulus terrestris grass (freed from fruits) on the models of carrageenan and zymosan inflammation in rats. In the models of carrageenan and zymosan edema in rats, a thick extract of Tribulus terrestris L. in doses from 50 mg/kg to 200 mg/kg shows anti-inflammatory activity, the efficacy of which in the dose range of 150-200 mg/g in the initial stages of carrageenan inflammation is not inferior to sodium diclofenac at a dose of 8.0 mg/kg, and in the initial stages of zymosan inflammation, respectively, before the reference drug corvitin at a dose of 10 mg/kg. It indicates the anticyclogenase and antilipoxygenase properties of this thick extract.