Challenges in defining treatment-resistant mania in adults: A systematic review
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články, systematický přehled
Grantová podpora
R21 MH123849
NIMH NIH HHS - United States
PubMed
37963496
PubMed Central
PMC10922285
DOI
10.1111/bdi.13383
Knihovny.cz E-zdroje
- Klíčová slova
- bipolar disorder, clinical trials, mania, pharmacotherapy, psychopharmacology, systematic review, treatment refractory, treatment resistance,
- MeSH
- bipolární porucha diagnóza farmakoterapie MeSH
- dospělí MeSH
- lidé MeSH
- mánie * farmakoterapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- systematický přehled MeSH
OBJECTIVES: To review the definitions of treatment-resistant mania (TRM) in the literature and propose criteria for an operationalized definition. METHODS: A systematic search of five databases (MEDLINE, EMBASE, PsychInfo, Cochrane Central, and CINAHL) and data extraction of eligible articles. RESULTS: In total, 47 articles addressing the concept of TRM were included, comprising 16 case reports, 11 case series, 3 randomized clinical trials, 8 open-label clinical trials, 1 experimental study, 7 narrative reviews, and 1 systematic review. While reviews discussed several challenges in defining TRM, definitions varied substantially based on different criteria for severity of mania, duration of mania, and use of specific therapeutic agents with minimal dosages and duration of treatment. Only a handful of the reviewed articles operationalized these criteria. CONCLUSION: While the concept of TRM has been discussed in the literature for over three decades, we could not find an agreed-upon operationalized definition based on specific criteria. We propose and discuss a possible definition that could be used by clinicians to guide their practice and by researchers to assess the prevalence of TRM and develop and test interventions targeting TRM.
Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada
Department of Psychiatry Temerty Faculty of Medicine University of Toronto Toronto Ontario Canada
Department of Psychiatry Weil Cornell Medicine New York New York USA
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