The diabetes care continuum in Venezuela: Cross-sectional and longitudinal analyses to evaluate engagement and retention in care
Status PubMed-not-MEDLINE Language English Country United States Media electronic-ecollection
Document type Journal Article
Grant support
T32 HL098048
NHLBI NIH HHS - United States
PubMed
38232087
PubMed Central
PMC10793920
DOI
10.1371/journal.pgph.0002763
PII: PGPH-D-23-01214
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
The impact of the humanitarian crisis in Venezuela on care for noncommunicable diseases (NCDs) such as diabetes is unknown. This study aims to document health system performance for diabetes management in Venezuela during the humanitarian crisis. This longitudinal study on NCDs is nationally representative at baseline (2014-2017) and has follow-up (2018-2020) data on 35% of participants. Separate analyses of the baseline population with diabetes (n = 585) and the longitudinal population with diabetes (n = 210) were conducted. Baseline analyses constructed a weighted care continuum: all diabetes; diagnosed; treated; achieved glycaemic control; achieved blood pressure, cholesterol, and glycaemic control; and achieved aforementioned control plus non-smoking. Weighted multinomial regression models controlling for region were used to estimate the association between socio-demographic characteristics and care continuum stage. Longitudinal analyses constructed an unweighted care continuum: all diabetes; diagnosed; treated; and achieved glycaemic control. Unweighted multinomial regression models controlling for region were used to estimate the association between socio-demographic characteristics and changes in care continuum stage. Among 585 participants with diabetes at baseline, 71% were diagnosed, 51% were on treatment, and 32% had achieved glycaemic control. Among 210 participants with diabetes in the longitudinal population, 50 (24%) participants' diabetes management worsened, while 40 (19%) participants improved. Specifically, the proportion of those treated decreased (60% in 2014-2017 to 51% in 2018-2020), while the proportion of participants achieving glycaemic control did not change. Although treatment rates have declined substantially among people with diabetes in Venezuela, management changed less than expected during the crisis.
Foundation for Clinic Public Health and Epidemiology Research of Venezuela Caracas Venezuela
Global Academy of Agriculture and Food Systems The University of Edinburgh Midlothian United Kingdom
Institute of Applied Health Research University of Birmingham Birmingham United Kingdom
International Clinical Research Center St Ann's University Hospital Brno Czech Republic
Precision Care Clinic Corp Saint Cloud Florida United States of America
Research Department Endocrine Associates of Florida Orlando Florida United States of America
See more in PubMed
Kehlenbrink S, Jaacks LM, Aebischer Perone S, Ansbro É, Ashbourne E, Atkinson C, et al.. Diabetes in humanitarian crises: the Boston Declaration. The Lancet Diabetes & Endocrinology. 2019;7(8):590–2. doi: 10.1016/S2213-8587(19)30197-4 PubMed DOI
UNHCR. Global Trends at a Glance. Forced Displacement in 2018. Geneva: UNHCR; 2019.
Rigaud KK, de Sherbinin A, Jones B, Bergmann J, Clement V, Ober K, et al.. Groundswell: Preparing for Internal Climate Migration. World Bank; 2018.
Perone SA, Martinez E, Du Mortier S, Rossi R, Pahud M, Urbaniak V, et al.. Non-communicable diseases in humanitarian settings: ten essential questions. Conflict and health. 2017;11(1):1–11. PubMed PMC
Goodman D, González-Rivas JP, Jaacks LM, Duran M, Marulanda MI, Ugel E, et al.. Dietary intake and cardiometabolic risk factors among Venezuelan adults: a nationally representative analysis. BMC nutrition. 2020;6(1):1–13. doi: 10.1186/s40795-020-00362-7 PubMed DOI PMC
Khan Y, Albache N, Almasri I, Gabbay RA. The management of diabetes in conflict settings: Focus on the Syrian crisis. Diabetes Spectrum. 2019;32(3):264–9. doi: 10.2337/ds18-0070 PubMed DOI PMC
Ng J, Atkin S, Rigby A, Walton C, Kilpatrick E. The effect of extensive flooding in Hull on the glycaemic control of patients with diabetes. Diabetic Medicine. 2011;28(5):519–24. doi: 10.1111/j.1464-5491.2011.03228.x PubMed DOI
Al-Sharafi B, Al-Tahami B. The effect of war on the control of diabetes in patients with type 2 diabetes mellitus in Yemen: a cross-sectional study. Endocrinol Metab Syndr. 2017;6(270):2161–1017.10002.
Kulenovic I, Robertson A, Grujic M, Suljevic E, Smajkic A. The impact of war on Sarajevans with non-insulin-dependent diabetes mellitus. The European Journal of Public Health. 1996;6(4):252–6.
Fonseca VA, Smith H, Kuhadiya N, Leger SM, Yau CL, Reynolds K, et al.. Impact of a natural disaster on diabetes: exacerbation of disparities and long-term consequences. Diabetes care. 2009;32(9):1632–8. doi: 10.2337/dc09-0670 PubMed DOI PMC
Inui A, Kitaoka H, Majima M, Takamiya S, Uemoto M, Yonenaga C, et al.. Effect of the Kobe earthquake on stress and glycemic control in patients with diabetes mellitus. Archives of internal medicine. 1998;158(3):274–8. doi: 10.1001/archinte.158.3.274 PubMed DOI
Roglic G, Metelko Z. Effect of war on glycemic control in type II diabetic patients. Diabetes care. 1993;16(5):806–8. doi: 10.2337/diacare.16.5.806 PubMed DOI
Rubinstein A, Koffler M, Villa Y, Graff E. The Gulf War and diabetes mellitus. Diabetic medicine. 1993;10(8):774–6. doi: 10.1111/j.1464-5491.1993.tb00163.x PubMed DOI
Data Bank: Venezuela [Internet]. 2021. Available from: https://data.worldbank.org/country/VE.
González-Rivas JP, Mechanick J, C. P D. dO-G R. I-F, L M, et al.. Impact of the complex humanitarian crisis on the epidemiology of the cardiometabolic risk factors in Venezuela. Clínica e Investigación en Arteriosclerosis. 2021;In Press. doi: 10.1016/j.arteri.2021.04.002 PubMed DOI
Nieto-Martínez R, González-Rivas JP, Lima-Martínez M, Stepenka V, Rísquez A, Mechanick JI. Diabetes care in Venezuela. Annals of global health. 2015;81(6):776–91. doi: 10.1016/j.aogh.2015.11.002 PubMed DOI
Nieto-Martínez R, Hamdy O, Marante D, Marulanda MI, Marchetti A, Hegazi RA, et al.. Transcultural diabetes nutrition algorithm (tDNA): Venezuelan application. Nutrients. 2014;6(4):1333–63. doi: 10.3390/nu6041333 PubMed DOI PMC
Nieto-Martínez R, González-Rivas JP, Ugel E, Duran M, Dávila E, Constantino R, et al.. Cardiometabolic risk factors in Venezuela. The EVESCAM study: a national cross-sectional survey in adults. Primary care diabetes. 2021;15(1):106–14. doi: 10.1016/j.pcd.2020.07.006 PubMed DOI
Cheatham A, Labrador RC. Venezuela: The Rise and Fall of a Petrostate. Council on Foreign Relations; 2021.
Doocy S, Ververs M-T, Spiegel P, Beyrer C. The food security and nutrition crisis in Venezuela. Soc Sci Med. 2019;226:63–8. doi: 10.1016/j.socscimed.2019.02.007 PubMed DOI
R4V. REFUGIADOS Y MIGRANTES DE VENEZUELA: Inter-Agency Coordination Platform for Refugees and Migrants from Venezuela; 2023. [updated 3/28/2023. Available from: https://www.r4v.info/es/refugiadosymigrantes#.
Page KR, Doocy S, Ganteaume FR, Castro JS, Spiegel P, Beyrer C. Venezuela’s public health crisis: a regional emergency. The Lancet. 2019. doi: 10.1016/S0140-6736(19)30344-7 PubMed DOI
Nieto-Martínez R, Inés Marulanda M, González-Rivas JP, Ugel E, Durán M, Barengo N, et al.. Cardio-Metabolic Health Venezuelan Study (EVESCAM): Design and Implementation. Investigacion Clinica. 2017;58(1):56–69. PubMed
Association AD. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2019. Diabetes Care. 2019;42(Supplement 1):S13. PubMed
Kay ES, Batey DS, Mugavero MJ. The HIV treatment cascade and care continuum: updates, goals, and recommendations for the future. AIDS research and therapy. 2016;13(1):1–7. doi: 10.1186/s12981-016-0120-0 PubMed DOI PMC
Ali MK, Bullard KM, Gregg EW, Del Rio C. A cascade of care for diabetes in the United States: visualizing the gaps. Annals of internal medicine. 2014;161(10):681–9. doi: 10.7326/M14-0019 PubMed DOI
American Diabetes Association. 6. Glycemic targets: standards of medical care in diabetes—2021. Diabetes Care. 2021;44(Supplement_1):S73–S84. PubMed
Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ, et al.. Translating the A1C assay into estimated average glucose values. Diabetes care. 2008;31(8):1473–8. doi: 10.2337/dc08-0545 PubMed DOI PMC
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al.. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. hypertension. 2003;42(6):1206–52. doi: 10.1161/01.HYP.0000107251.49515.c2 PubMed DOI
Grundy SM, Becker D, Clark LT, Cooper RS, Denke MA, Howard J, et al.. Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Circulation. 2002;106(25):3143–421. PubMed
Health NIo. Clinical guidelines for the identification, evaluation, and treatment of overweight and obesity in adults-the evidence report. Obes res. 1998;6(2):51S–209S. PubMed
Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: an exposure-wide umbrella review of meta-analyses. PLoS ONE. 2018;13(3):e0194127. doi: 10.1371/journal.pone.0194127 PubMed DOI PMC
Manne-Goehler J, Geldsetzer P, Agoudavi K, Andall-Brereton G, Aryal KK, Bicaba BW, et al.. Health system performance for people with diabetes in 28 low- and middle-income countries: A cross-sectional study of nationally representative surveys. PLoS Med. 2019;16(3). doi: 10.1371/journal.pmed.1002751 PubMed DOI PMC
Hunt D, Hemmingsen B, Matzke A, Varghese C, Hammerich A, Luciani S, et al.. The WHO Global Diabetes Compact: a new initiative to support people living with diabetes. The Lancet Diabetes & Endocrinology. 2021;9(6):325–7. doi: 10.1016/S2213-8587(21)00111-X PubMed DOI
Human Rights Watch. Venezuela’s Humanitarian Emergency. 2019.
Orozco M, Klaas K. Money Transfers to Venezuela: Remittance Flows Amidst Evolving Foreign Exchange. Washington DC: Inter-American Dialogue. 2020.
Giordano TP. The HIV Treatment Cascade—A New Tool in HIV Prevention. JAMA Internal Medicine. 2015;175(4):596–7. doi: 10.1001/jamainternmed.2014.8199 PubMed DOI
Haber N, Pillay D, Porter K, Bärnighausen T. Constructing the cascade of HIV care: methods for measurement. Current Opinion in HIV and AIDS. 2016;11(1):102–8. doi: 10.1097/COH.0000000000000212 PubMed DOI
Mazuera-Arias R, Albornoz-Arias N, Morffe Peraza MÁ. Informe sobre la movilidad humana venezolana II. Realidades y perspectivas de quienes emigran (8 de abril al 5 de mayo de 2019). 2019.
Unwin N, Howitt C, Rose AM, Samuels TA, Hennis AJ, Hambleton IR. Prevalence and phenotype of diabetes and prediabetes using fasting glucose vs HbA1c in a Caribbean population. Journal of global health. 2017;7(2). PubMed PMC