Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
38277283
PubMed Central
PMC11191509
DOI
10.3233/cbm-230259
PII: CBM230259
Knihovny.cz E-zdroje
- Klíčová slova
- Breast cancer, GNG12-AS1, MAGI2-AS3, MEG3, NRSN2-AS1, PTENP1, UCA1, clinical outcomes, long non-coding RNAs,
- MeSH
- adaptorové proteiny signální transdukční genetika metabolismus MeSH
- dospělí MeSH
- guanylátkinasy genetika metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery * genetika metabolismus MeSH
- nádory prsu * genetika patologie metabolismus mortalita MeSH
- prognóza MeSH
- regulace genové exprese u nádorů MeSH
- RNA dlouhá nekódující * genetika MeSH
- senioři MeSH
- stupeň nádoru MeSH
- tumor supresorové geny MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- MAGI2 protein, human MeSH Prohlížeč
- MEG3 non-coding RNA, human MeSH Prohlížeč
BACKGROUND: Breast cancer is the most commonly occurring cancer worldwide and is the main cause of death from cancer in women. Novel biomarkers are highly warranted for this disease. OBJECTIVE: Evaluation of novel long non-coding RNAs biomarkers for breast cancer. METHODS: The study comprised the analysis of the expression of 71 candidate lncRNAs via screening, six of which (four underexpressed, two overexpressed) were validated and analyzed by qPCR in tumor tissues associated with NST breast carcinomas, compared with the benign samples and with respect to their clinicopathological characteristics. RESULTS: The results indicated the tumor suppressor roles of PTENP1, GNG12-AS1, MEG3 and MAGI2-AS3. Low levels of both PTENP1 and GNG12-AS1 were associated with worsened progression-free and overall survival rates. The reduced expression of GNG12-AS1 was linked to the advanced stage. A higher grade was associated with the lower expression of PTENP1, GNG12-AS1 and MAGI2-AS3. Reduced levels of both MEG3 and PTENP1 were linked to Ki-67 positivity. The NRSN2-AS1 and UCA1 lncRNAs were overexpressed; higher levels of UCA1 were associated with multifocality. CONCLUSIONS: The results suggest that the investigated lncRNAs may play important roles in breast cancer and comprise a potential factor that should be further evaluated in clinical studies.
1st Faculty of Medicine Institute of Pharmacology Charles University Prague Czech Republic
Department of Obstetrics and Gynecology Masaryk University Brno Czech Republic
Department of Pathology Faculty of Medicine Masaryk University Brno Czech Republic
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