G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
38301873
DOI
10.1016/j.lfs.2024.122481
PII: S0024-3205(24)00070-5
Knihovny.cz E-zdroje
- Klíčová slova
- Biological activity, Drug-DNA interactions, G-quadruplex ligand, Heterocycle compounds, Ligand design, Structure-activity relationship,
- MeSH
- G-kvadruplexy * MeSH
- lidé MeSH
- ligandy MeSH
- nádory * farmakoterapie MeSH
- protinádorové látky * farmakologie terapeutické užití MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- ligandy MeSH
- protinádorové látky * MeSH
Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these structures promising anti-cancer targets. Compounds able to recognize these structures have been investigated as potential anticancer drugs; however, no G4 binder has yet been approved in the clinic. Here, we describe G4 ligands structure-activity relationships, in vivo effects as well as clinical trials. Addressing G4 ligand characteristics, targeting challenges, and structure-activity relationships, this review provides insights into the development of potent and selective G4-targeting molecules for therapeutic applications.
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