Cumulative incidence and risk factors for cutaneous squamous cell carcinoma metastases in organ transplant recipients: The Skin Care in Organ Transplant Patients in Europe-International Transplant Skin Cancer Collaborative metastases study, a prospective multicenter study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
Odkazy
PubMed
38301923
DOI
10.1016/j.jaad.2024.01.040
PII: S0190-9622(24)00157-9
Knihovny.cz E-zdroje
- Klíčová slova
- immunosuppression, organ transplantation, skin cancer, squamous cell carcinoma,
- MeSH
- dospělí MeSH
- incidence MeSH
- invazivní růst nádoru MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru epidemiologie MeSH
- nádory hlavy a krku epidemiologie patologie MeSH
- nádory kůže * epidemiologie patologie MeSH
- příjemce transplantátu statistika a číselné údaje MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- spinocelulární karcinom * epidemiologie MeSH
- staging nádorů MeSH
- transplantace orgánů * škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa epidemiologie MeSH
INTRODUCTION: Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors. METHODS: In a prospective cohort study, including 19 specialist dermatology outpatient clinics in 15 countries, patient and tumor characteristics were collected using standardized questionnaires when SOTRs presented with a new cSCC. After a minimum of 2 years of follow-up, relevant data for all SOTRs were collected. Cumulative incidence of metastases was calculated by the Aalen-Johansen estimator. Fine and Gray models were used to assess multiple risk factors for metastases. RESULTS: Of 514 SOTRs who presented with 623 primary cSCCs, metastases developed in 37 with a 2-year patient-based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size > 2 cm, clinical ulceration, poor differentiation grade, perineural invasion, and deep invasion. A high-stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2-year cumulative incidence of 46.2% (31.9%-68.4%). CONCLUSIONS: SOTRs have a high risk of cSCC metastases and well-established clinical and histologic risk factors have been confirmed. High-stage, ulcerated cSCCs have the highest risk of metastasis.
Department of Biomedical Data Sciences Leiden University Medical Center Leiden The Netherlands
Department of Dermatology Brigham and Women's Hospital Boston Massachusetts
Department of Dermatology Edouard Herriot Hospital Lyon France
Department of Dermatology Faculty of Medicine Baskent University Ankara Turkey
Department of Dermatology Hospital Universitari Vall d'Hebron Barcelona Spain
Department of Dermatology Leiden University Medical Center Leiden The Netherlands
Department of Dermatology Medical University of Vienna Vienna Austria
Department of Dermatology NHS Greater Glasgow and Clyde Glasgow United Kingdom
Department of Dermatology Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom
Department of Dermatology Royal London Hospital Barts Health NHS Trust London United Kingdom
Department of Dermatology University Hospital of Zürich University of Zürich Zürich Switzerland
Department of Dermatology University Hospitals Leuven Leuven Belgium
Department of Dermatology University of São Paulo Sao Paulo Brazil
Department of Dermatology Waikato Clinical Campus University of Auckland Hamilton New Zealand
Department of Dermatovenereology Charles University Hospital Pilsen Czech Republic
Molecular and Clinical Medicine School of Medicine University of Dundee Dundee United Kingdom
N Dermatology and STD Outpatient Clinic Copernicus Medical Centre Gdansk Poland
Population Health Department QIMR Berghofer Medical Research Institute Brisbane Australia
Unit of Dermatology Department of Medicine University of Padua Padua Italy