OBJECTIVES: Delirium is common during acute infection in older patients and is associated with functional decline. Geriatric rehabilitation (GR) can help older patients to return to their premorbid functional level. It is unknown whether delirium affects GR outcomes in patients with acute infection. We evaluated whether delirium affects trajectories of activities of daily living (ADL) and quality of life (QoL) recovery in GR after COVID-19 infection. DESIGN: This study was part of the EU-COGER study, a multicenter cohort study conducted between October 2020 and October 2021. SETTING AND PARTICIPANTS: Participants were recruited after COVID-19 infection from 59 GR centers in 10 European countries. METHODS: Data were collected at GR admission, discharge, and at the 6-week and 6-month follow-ups. Trajectories of ADL [using the Barthel index (BI)] and QoL [using the EuroQol-5 Dimensions-5 Level (EQ-5D-5L)] recovery were examined using linear mixed models. RESULTS: Of the 723 patients included (mean age 75.5 ± 9.9 years; 52.4% male), 28.9% had delirium before or during GR admission. Participants with delirium recovered in ADL at approximately the same rate as those without (linear slope effect = -0.13, SE 0.16, P = .427) up to an estimated BI score of 16.1 at 6 months. Similarly, participants with delirium recovered in QoL at approximately the same rate as those without (linear slope effect = -0.017, SE 0.015, P = .248), up to an estimated EQ-5D-5L score of 0.8 at 6 months. CONCLUSIONS AND IMPLICATIONS: Presence of delirium during the acute phase of infection or subsequent GR did not influence the recovery trajectory of ADL functioning and QoL.

Academic Unit of Injury Recovery and Inflammation Sciences School of Medicine University of Nottingham United Kingdom

Centre for Geriatric Medicine Agaplesion Bethanien Hospital Heidelberg Geriatric Centre at the Heidelberg University Heidelberg Germany

Department of Geriatric Medicine 1st Faculty of Medicine Charles University and General Faculty Hospital Prague Czech Republic; Faculty of Health and Social Sciences South Bohemian University České Budějovice Czech Republic

Department of Geriatric Medicine Beaumont Hospital Dublin Ireland

Department of Geriatrics Amphia Hospital Breda the Netherlands

Department of Health Services Research Maastricht University Maastricht The Netherlands

Department of Public Health and Primary Care Leiden University Medical Centre Leiden the Netherlands; University Network for the Care sector South Holland Leiden University Medical Center Leiden the Netherlands

Department of Public Health and Primary Care Leiden University Medical Centre Leiden the Netherlands; University Network for the Care sector South Holland Leiden University Medical Center Leiden the Netherlands; LUMC Center for Medicine for Older People Leiden University Medical Center Leiden the Netherlands

Fliman Geriatric Rehabilitation Centre Haifa Israel; Geriatric Division Holy Family Hospital Bar Ilan University Safad Israel

Geriatric Medicine Society of Malta and Telghet G'Mangia Rehabilitation Hospital Karin Grech Pietà Malta

IRCCS Istituti Clinici Maugeri University of Milan Milan Italy

RE FiT Barcelona Research Group Parc Sanitari Pere Virgili Hospital and Vall d'Hebron Institut de Recerca Barcelona Spain

Russian Clinical and Research Centre of Gerontology Moscow Russia

Section Geriatric Medicine Department of Internal Medicine Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands

Citace poskytuje Crossref.org