Fosfomycin-resistant FosA8-producing Enterobacterales are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing Escherichia coli ST131 in clinical isolates from two patients admitted in February 2023 to a rehabilitation unit in Italy. The occurrence of rare fosA-like genes in the high-risk clone ST131 is of clinical relevance. The dissemination of FosA-producing E. coli, although still at low levels, should be continuously monitored.

Biomedical Center Faculty of Medicine Charles University Pilsen Czechia

Department of Microbiology Faculty of Medicine University Hospital in Pilsen Charles University Pilsen Czechia

Microbiology Unit IRCCS Istituti Clinici Scientifici Maugeri Pavia Italy

Scienze Clinico Chirurgiche Diagnostiche Pediatriche Department Microbiology Unit University of Pavia Pavia Italy

Specialization School of Microbiology and Virology University of Pavia Pavia Italy

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FosA3 emerging in clinical carbapenemase-producing C. freundii