Histopathological aspects of usual interstitial pneumonia in patients with systemic connective tissue diseases
Jazyk angličtina Země Španělsko Médium print-electronic
Typ dokumentu časopisecké články, kazuistiky
PubMed
38934227
DOI
10.14670/hh-18-777
PII: HH-18-777
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- idiopatická plicní fibróza patologie komplikace MeSH
- intersticiální plicní nemoci * patologie komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci pojiva * patologie komplikace MeSH
- plíce patologie diagnostické zobrazování MeSH
- počítačová rentgenová tomografie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Five cases of patients with systemic connective tissue diseases (CTD) who developed connective tissue disease-associated interstitial lung disease (CTD-ILD) with progressive pulmonary fibrosis (PPF) are reported here. Unspecified ILD was diagnosed using high-resolution computed tomography (HRCT). Histologically, all cases were usual interstitial pneumonia (UIP) with findings of advanced (3/5) to diffuse (2/5) fibrosis, with a partially (4/5) to completely (1/5) formed image of a honeycomb lung. The fibrosis itself spread subpleurally and periseptally to more central parts (2/5) of the lung, around the alveolar ducts (2/5), or even without predisposition (1/5). Simultaneously, there was architectural reconstruction based on the mutual fusion of fibrosis without compression of the surrounding lung parenchyma (1/5), or with its compression (4/5). The whole process was accompanied by multifocal (1/5), dispersed (2/5), or organized inflammation in aggregates and lymphoid follicles (2/5). As a result of continuous fibroproduction and maturation of the connective tissue, the alveolar septa thickened, delimiting groups of alveoli that merged into air bullae. Few indistinctly visible (2/5), few clearly visible (1/5), multiple indistinctly visible (1/5), and multiple clearly visible (1/5) fibroblastic foci were present. Among the concomitant changes, areas of emphysema, bronchioloectasia, and bronchiectasis, as well as bronchial and vessel wall hypertrophy, and mucostasis in the alveoli and edema were observed. The differences in the histological appearance of usual interstitial pneumonia associated with systemic connective tissue diseases (CTD-UIP) versus the pattern associated with idiopathic pulmonary fibrosis (IPF-UIP) are discussed here. The main differences lie in spreading lung fibrosis, architectural lung remodeling, fibroblastic foci, and inflammatory infiltrates.
Department of Clinical Neurosciences Ostrava University Hospital Ostrava Poruba Czech Republic
Department of Zoology Faculty of Natural Sciences Comenius University Bratislava Slovak Republic
Zobrazit více v PubMed
Alhamad E.H. (2015). Clinical characteristics and survival in idiopathic pulmonary fibrosis and connective tissue disease-associated usual interstitial pneumonia. J. Thorac. Dis. 7, 386-393. PubMed PMC
Ali M.F., Egan A.M., Shaughnessy G.F., Anderson D.K., Kottom T.J., Dasari H., van Keulen V.P., Aubry M.C.-H., Yi E.S., Limper A.H., Peikert T. and Carmona E.M. (2021). Antifibrotics Modify B-Cell- induced fibroblast migration and activation in patients with idiopathic pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 64, 722-733. PubMed PMC
Antin-Ozerkis D., Rubinowitz A., Evans J., Homer R.J. and Matthay R.A. (2012). Interstitial lung disease in the connective tissue diseases. Clin. Chest. Med. 33, 123-149. PubMed
Bahner T., Romagnoli M., Girelli F., Clausen M. and Rabe K.F. (2016). The use of auto-antibody testing in the evaluation of interstitial lung disease (ILD)--A practical approach for the pulmonologist. Respir. Med. 113, 80-92. PubMed
Castillo D., Walsh S., Hansell D.M., Vasakova M., Cottin V., Altinisik G., Palmucci S., Sterclova M., Harari S., Richeldi L., Vancheri C. and Wells A.U. (2018). Validation of multidisciplinary diagnosis in IPF. Lancet Respir. Med. 6, 88-89. PubMed
Cipriani N.A., Strek M., Noth I., Gordon I.O., Charbeneau J., Krishnan J.A., Krausz T. and Husain A.N. (2012). Pathologic quantification of connective tissue disease-associated versus idiopathic usual interstitial pneumonia. Arch. Pathol. Lab. Med. 136, 1253-1258. PubMed
Cottin V. (2013). Significance of connective tissue diseases featured in pulmonary fibrosis. Eur. Respir. Rev. 22, 273-280. PubMed PMC
Chiang G.C. and Parimon T. (2023). Understanding interstitial lung diseases associated with connective tissue disease (CTD-ILD): genetics, cellular pathophysiology, and biologic drivers. Int. J. Mol. Sci. 24, 2405. PubMed PMC
de Lauretis A., Veeraraghavan S. and Renzoni E. (2011). Review series: Aspects of interstitial lung disease: connective tissue disease-associated interstitial lung disease: how does it differ from IPF? How should the clinical approach differ? Chron. Respir. Dis. 8, 53-82. PubMed
Hamblin M., Prosch H. and Vasakova M. (2022). Diagnosis, course and management of hypersensitivity pneumonitis. Eur. Respir. Rev. 31, 210169. PubMed PMC
Kishaba T. (2022). Current perspective of progressive-fibrosing interstitial lung disease. Respir. Investig. 60, 503-509. PubMed
Lee J., Kim K. and Jo Y.S. (2023). Comparison of the diagnostic criteria for progressive pulmonary fibrosis in connective tissue disease- related interstitial lung disease. Respir. Med. 212, 107242. PubMed
Luppi F., Manfredi A., Faverio P., Brun Andersen M., Bono F., Pagni F., Salvarani C., Bendstrup R. and Sebastiani M. (2023). The usual interstitial pneumonia pattern in autoimmune rheumatic diseases. BMC Pulm. Med. 23, 501. PubMed PMC
Makovická M., Vrbenská A., Makovický P., Durcová B., Škarda J., Kamarád V., Miklošová M., Michalčová P., Kráľová K. and Muri J. (2024). Histopathological findings in lung biopsies with usual interstitial pneumonia: Definition of a new classification score for histological fibrotic stages. Gen. Physiol. Biophys. 43, 49-56. PubMed
Matěj R. (2023). Current possibilities of histopathologic separation of idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis. How to do it? Cesk. Patol. 59, 10-17. PubMed
Mathai S. and Danoff S.K. (2016). Management of interstitial lung disease associated with connective tissue disease. Br. Med J. 352, h6819. PubMed PMC
Muri J., Chylikova J., Skarda J., Miklosova M. and Kamarad V. (2022). The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub. 166, 136-139. PubMed
Prele C.M., Miles T., Pearce D.R., ODonoghue R.J., Garinge C., Barrett L., Birnie K., Lucas A.D., Baltic S., Ernst M., Rinaldi C., Laurent G.J., Knight D.A., Fear M., Hoyne G., McAnulty R.J. and Mutseers S.E. (2022). Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis. Eur. Respir. J. 60, 2101469. PubMed PMC
Pugashetti J.V., Adegunsoye A., Wu Z., Lee C.T., Srikrishnan A., Ghodrati S., Vo V., Renzoni E.A., Wella A.U., Kim Garcia K., Chua F., Newton Ch.A., Molyneaux P.L. and Oldham J.M. (2023). Validation of proposed criteria for progressive pulmonary fibrosis. Am. J. Respir. Crit. Care. Med. 207, 69-76. PubMed PMC
Strand M.J., Sprunger D., Cosgrove G., Fernandez-Perez E.R., Frankel S.K., Huie T.J., Olson A.L., Solomon J., Brown K.K. and Swigris J.J. (2014). Pulmonary functions and survival in idiopathic vs secondary usual interstitial pneumonia. Chest 146, 775-785. PubMed PMC
Strange C. and Highland K.B. (2004). Interstitial lung disease in the patient who has connective tissue disease. Clin. Chest Med. 25, 549-559. PubMed
Teoh A.K.Y., Holland A.E., Morisset J., Flaherty K.R., Wells A.U., Walsh S.L.F., Glaspole I., Wuyts W.A. and Corte T.J. (2022). Essential features of an interstitial lung disease multidisciplinary meeting: An international delphi survey. Ann. Am. Thorac. Soc. 19, 66-73. PubMed
Zhao Y.Y., Lian H.J., Li S., Fang C.L., Huang H. and Xu Z.J. (2018). The role of B-cell activating factor in the differential diagnosis of usual interstitial pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 41, 544-550 (in Chinese). PubMed