Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) in subjects after Covid-19 infection: single-center prospective study
Jazyk angličtina Země Polsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
MO 1012
Ministry of Defence of the Czech Republic - Czech Republic
108/16-24/2021
Ethics Committee of the Military University Hospital Prague - Czech Republic
PubMed
39434512
DOI
10.32725/jab.2024.020
Knihovny.cz E-zdroje
- Klíčová slova
- Chemosensory functions, Covid-19, OERPs, Olfactory dysfunction, Post-covid, Smell, TERPs,
- MeSH
- čich fyziologie MeSH
- COVID-19 * patofyziologie MeSH
- dospělí MeSH
- evokované potenciály * fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nervus trigeminus patofyziologie virologie MeSH
- poruchy čichu * patofyziologie virologie etiologie diagnóza MeSH
- prospektivní studie MeSH
- SARS-CoV-2 * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: Olfactory dysfunction (OD) is a common symptom associated with Covid-19. During the Covid-19 pandemic, the importance of psychophysical olfactory tests and electrophysiological olfactory assessment increased. The purpose of the study was to analyze the psychophysical olfactory tests and the post-covid curves of olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs). METHODS: The prospective study included 98 subjects (62 females / 36 males). The average age was 42 years (range 21-84 years). Group I (n = 77) contained participants who had been infected with Covid-19. They were enrolled in the study at least 1 year after Covid-19. Group II (n = 21) was the healthy normosmic control group. RESULTS: In Group I, the OERPs of 18% participants were absent. Patients in Group I were statistically more likely to have an absence of OERPs (p = 0.036) than subjects in Group II. We did not detect a statistical difference in amplitudes and latencies of the OERPs between Group I and Group II. In Group I, N1 latency of the TERPs was significantly longer (p = 0.002) than in Group II. The amplitude of the N1-P2 interval of the TERPs was significantly lower (p = 0.025) in Group I than in Group II. According to the psychophysical Sniffin stick identification test, hyposmia was detected in 39% in Group I versus 0% in the control Group II. CONCLUSION: OD is a common post-covid symptom. The presence of OERPs is a significant prognostic factor for olfactory function after Covid 19. We detected a lower percentage of absence of OERPs after Covid-19 compared to the previously published studies of post-viral OD and post-infectious OD. For TERPs, we detected a longer N1 latency and a lower amplitude for the N1-P2 interval after Covid-19. OERPs and TERPs can be considered valid biomarkers to evaluate the progress of post-covid OD.
Charles University 1st Faculty of Medicine Prague Czech Republic
Charles University 2nd Faculty of Medicine Prague Czech Republic
Charles University 3rd Faculty of Medicine Prague Czech Republic
Military Hospital Brno Department of Neurology Brno Czech Republic
Military University Hospital Prague Department of Neurology Prague Czech Republic
University Hospital Motol Department of Ear Nose and Throat Prague Czech Republic
University of Pardubice Faculty of Health Studies Pardubice Czech Republic
Zobrazit více v PubMed
Boscolo-Rizzo P, Hummel T, Spinato G, Angelo Vaira L, Menini A, Hopkins C, Tirelli G (2024). Olfactory and Gustatory Function 3 Years After Mild COVID-19-A Cohort Psychophysical Study. JAMA Otolaryngol Head Neck Surg 150(1): 79-81. DOI: 10.1001/jamaoto.2023.3603. PubMed DOI
Burges Watson DL, Campbell M, Hopkins C, Smith B, Kelly C, Deary V (2021). Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19. PLoS One 16(9): e0256998. DOI: 10.1371/journal.pone.0256998. PubMed DOI
Červený K, Janoušková K, Vaněčková K, Zavázalová Š, Funda D, Astl J, Holy R (2022). Olfactory Evaluation in Clinical Medical Practice. J Clin Med 11(22): 6628. DOI: 10.3390/jcm11226628. PubMed DOI
Guo Y, Wu D, Sun Z, Yao L, Liu J, Wei Y (2021a). Prognostic value of olfactory evoked potentials in patients with post-infectious olfactory dysfunction. Eur Arch Otorhinolaryngol 278(10): 3839-3846. DOI: 10.1007/s00405-021-06683-y. PubMed DOI
Guo Y, Yao L, Sun Z, Huang X, Liu J, Wei Y (2021b). [Predictors of posttreatment olfactory improvement in patients with postviral olfactory dysfunction]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 35(12): 1057-1062. DOI: 10.13201/j.issn.2096-7993.2021.12.001 (Chinese). PubMed DOI
Holy R, Janouskova K, Vasina L, Maute E, Kalfert D, Maminak K, et al. (2023). Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell. J Appl Biomed 21(4): 167-173. DOI: 10.32725/jab.2023.020. PubMed DOI
Hummel T, Liu DT, Müller CA, Stuck BA, Welge-Lüssen A, Hähner A (2023). Olfactory Dysfunction: Etiology, Diagnosis, and Treatment. Dtsch Arztebl Int 120(9): 146-154. DOI: 10.3238/arztebl.m2022.0411. PubMed DOI
Invitto S, Boscolo-Rizzo P, Fantin F, Bonifati DM, de Filippis C, Emanuelli E, et al. (2023). Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway? Bioengineering (Basel) 10(3): 376. DOI: 10.3390/bioengineering10030376. PubMed DOI
Jung T, Choi BY, Jang M, Kim T, Seo E, Kim JK (2023). Comparative Analysis of Olfactory and Gustatory Function of Patients With COVID-19 Olfactory Dysfunction and Non-COVID-19 Postinfectious Olfactory Dysfunction. J Korean Med Sci 38(43): e352. DOI: 10.3346/jkms.2023.38.e352. PubMed DOI
Kovář D, Holý R, Voldřich Z, Fundová P, Astl J (2017). The Contribution of CT Navigation in Endoscopic Sinus Surgery: An Evaluation of Patient Postoperative Quality of Life and Olfaction Function Results. Otorinolaryngol Foniatr 66(4): 205-209.
Liu J, Pinto JM, Yang L, Li L, Sun J, Miao X, et al. (2016). Gender difference in Chinese adults with post-viral olfactory disorder: a hospital-based study. Acta Otolaryngol 136(9): 976-981. DOI: 10.3109/00016489.2016.1172729. PubMed DOI
Liu J, Zhan LY, Yao X, Gao HB, Xie FF, Chang F (2022). [The importance of intranasal trigeminal event-related potentials test for patients with olfactory dysfunction]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 57(8): 974-979. DOI: 10.3760/cma.j.cn115330-20220407-00174 (Chinese). PubMed DOI
Luke L, Lee L, Jegatheeswaran L, Philpott C (2022). Investigations and Outcomes for Olfactory Disorders. Curr Otorhinolaryngol Rep 10(4): 377-384. DOI: 10.1007/s40136-022-00438-x. PubMed DOI
Najafloo R, Majidi J, Asghari A, Aleemardani M, Kamrava SK, Simorgh S, et al. (2021). Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments. ACS Chem Neurosci 12(20): 3795-3805. DOI: 10.1021/acschemneuro.1c00477. PubMed DOI
Ohla K, Veldhuizen MG, Green T, Hannum ME, Bakke AJ, Moein ST, et al. (2022). A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss. Rhinology 60(3): 207-217. DOI: 10.4193/Rhin21.415. PubMed DOI
Pastorkova N, Janouskova K, Vasina L, Schulz H, Astl J, Holy R (2023). Postcovid Guillain-Barré syndrome with severe course - case series two patients including clinical evaluation of smell and examination of olfactory event-related potentials (OERPs). Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. DOI: 10.5507/bp.2023.014 (online ahead of print). PubMed DOI
Ren Y, Yang L, Guo Y, Xutao M, Li K, Wei Y (2012). Intranasal trigeminal chemosensitivity in patients with postviral and post-traumatic olfactory dysfunction. Acta Otolaryngol 132(9): 974-980. DOI: 10.3109/00016489.2012.663933. PubMed DOI
Rombaux P, Huart C, Collet S, Eloy P, Negoias S, Hummel T (2010). Presence of olfactory event-related potentials predicts recovery in patients with olfactory loss following upper respiratory tract infection. Laryngoscope 120(10): 2115-2118. DOI: 10.1002/lary.21109. PubMed DOI
Rombaux P, Huart C, Mouraux A (2012). Assessment of chemosensory function using electroencephalographic techniques. Rhinology 50(1): 13-21. DOI: 10.4193/Rhino11.126. PubMed DOI
Rombaux P, Mouraux A, Bertrand B, Guerit JM, Hummel T (2006). Assessment of olfactory and trigeminal function using chemosensory event-related potentials. Neurophysiol Clin 36(2): 53-62. DOI: 10.1016/j.neucli.2006.03.005. PubMed DOI
Tervo JP, Jacobson PT, Vilarello BJ, Saak TM, Caruana FF, Gallagher LW, et al. (2024). Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study. World J Otorhinolaryngol Head Neck Surg 10(2): 79-87. DOI: 10.1002/wjo2.179. PubMed DOI
Vodička J, Menšíková A, Balatková Z, Shejbalová H, Racková R, Matoušek P, et al. (2011). Fyziologické hodnoty čichových testů v české populace [Physiological values of olfactory tests in the Czech population]. Otorinolaryngol Foniatr 60(3): 119-124.
Whitcroft KL, Altundag A, Balungwe P, Boscolo-Rizzo P, Douglas R, Enecilla MLB, et al. (2023). Position paper on olfactory dysfunction: 2023. Rhinology 61(33): 1-108. DOI: 10.4193/Rhin22.483. PubMed DOI
