To transfer mitochondria or not to transfer mitochondria: ADP does the trick
Language English Country United States Media electronic-ecollection
Document type Journal Article, Comment
PubMed
40359483
PubMed Central
PMC11326585
DOI
10.1371/journal.pbio.3002754
PII: PBIOLOGY-D-24-01721
Knihovny.cz E-resources
- MeSH
- Adenosine Diphosphate * metabolism MeSH
- Humans MeSH
- Mitochondria * metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Names of Substances
- Adenosine Diphosphate * MeSH
Horizontal mitochondrial transfer (HMT) has emerged as a novel phenomenon in cell biology, but it is unclear how this process of intercellular movement of mitochondria is regulated. A new study in PLOS Biology reports that ADP released by stressed cells is a signal that triggers HMT.
Faculty of Science and 1st Faculty of Medicine Charles University Prague Czech Republic
Institute of Biotechnology Czech Academy of Sciences Prague Czech Republic
School of Pharmacy and Medical Science Griffith University Southport Australia
See more in PubMed
Dong LF, Rohlena J, Zobalova R, Rodriguez AM, Berridge MV, Neuzil J. Mitochondria on the move: Horizontal transfer of mitochondria in disease and health. J Cell Biol. 2023;222:e202211044. PubMed PMC
Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science. 2004;303:1007–1010. doi: 10.1126/science.1093133 PubMed DOI
Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, et al.. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential in cancer cells without mitochondrial DNA. Cell Metab. 2015;21:81–94. PubMed
Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, et al.. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016;535:551–555. doi: 10.1038/nature18928 PubMed DOI PMC
Gao J, Qin A, Liu D, Ruan R, Wang Q, Yuan J, et al.. Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv. 2019;5:eaaw7215. doi: 10.1126/sciadv.aaw7215 PubMed DOI PMC
Liao P, Chen L, Zhou H, Mei J, Chen Z, Wang B, et al.. Osteocyte mitochondria regulate angiogenesis of transcortical vessels. Nat Commun. 2024;15:2529. doi: 10.1038/s41467-024-46095-0 PubMed DOI PMC
Zhou H, Zhang W, Li H, Xu F, Yinwang E, Xue Y, et al.. Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity. Sci Adv. 2024;10:eadi4298. doi: 10.1126/sciadv.adi4298 PubMed DOI PMC
Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, et al.. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat Cell Biol. 2009;11:1427–1432. doi: 10.1038/ncb1990 PubMed DOI
Qin Y, Jiang X, Yang Q, Zhao J, Zhou Q, Zhou Y. The functions, methods, and mobility of mitochondrial transfer. Front Oncol. 2021;11:672781. PubMed PMC
Vultaggio-Poma V, Falzoni S, Salvi G, Giuliani AL, Di Virgilio F. Signalling by extracellular nucleotides in health and disease. Biochim Biophys Acta Mol Cell Res. 2022;1869(5):119237. doi: 10.1016/j.bbamcr.2022.119237 PubMed DOI
Li H, Yu H, Liu D, Liao P, Gao C, Zhou J, et al.. Adenosine diphosphate released from stressed cells trigger mitochondrial transfer in tissue homeostasis. PLoS Biol. 2024; 22(8):e3002753. doi: 10.1371/journal.pbio.3002753 PubMed DOI PMC
