Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD)
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
40414630
DOI
10.1016/bs.irn.2025.04.005
PII: S0074-7742(25)00020-0
Knihovny.cz E-zdroje
- Klíčová slova
- Gut microbiota, Insulin resistance, Neurodegenerative disorders, Oxidative stress, Probiotics,
- MeSH
- Alzheimerova nemoc * mikrobiologie metabolismus patofyziologie MeSH
- dysbióza * komplikace metabolismus MeSH
- lidé MeSH
- probiotika terapeutické užití MeSH
- střevní mikroflóra * fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Changes in the makeup of gut microbiota are linked to many neuropsychiatric diseases. Although the exact connection between gut dysbiosis and brain dysfunction is not yet fully understood, but recent data suggests that gut dysbiosis may contribute to the development of Alzheimer's disease (AD) by promoting neuroinflammation, insulin resistance, oxidative stress, and amyloid-beta (Aβ) aggregation. Gut dysbiosis in animal models is primarily characterized by an elevated ratio of Firmicutes/Bacteroidetes which may lead to the accumulation of amyloid precursor protein (APP) in the intestine, in the early stages of AD. Probiotics play a significant role in preventing against the symptoms of AD by restoring gut-brain homeostasis. This chapter provides an overview of the gut microbiota and its dysregulation in etiology of AD. Moreover, novel insights into alteration of the composition of gut microbiota as a preventive or therapeutic approach to AD are discussed.
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