Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
Grantová podpora
CEECIND/04663/2017
Fundação para a Ciência e a Tecnologia
GEDII Project Award 2019
Grupo de Estudos da Doença Intestinal Inflamatória
Daniel Alagille Award 2019
European Association for the Study of the Liver
PID 23709
CEITEC Proteomic Core Facility, a part of Czech Infrastructure for Integrative Structural Biology (CIISB), Instruct-CZ Centre of Instruct-ERIC EU consortium funded by Instruct-ERIC
LM2023042 and e-INFRA CZ (ID:90254)
Ministry of Education, Youth and Sports CR
PI21/00922 - PI18/01075
Instituto de Salud Carlos III
CPII19/00008
Miguel Servet plus Fondo Europeo de Desarrollo Regional" (FEDER)
PI22/00526
Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain, co-funded by the European Regional Development Fund/European Social Fund, "Investing in your future"
SA113P23
Junta de Castilla Control Leon
PID2022-140210OB-I00
AECC Scientific Foundation (2023/2027). Ministerio de Ciencia e Innovación.
PubMed
40476597
DOI
10.1042/cs20256078
PII: 236163
Knihovny.cz E-zdroje
- Klíčová slova
- GCDCA, IBD, PSC, bile acids, immune response,
- MeSH
- dospělí MeSH
- idiopatické střevní záněty * imunologie komplikace krev genetika MeSH
- kolon metabolismus imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- monocyty imunologie metabolismus MeSH
- proteomika metody MeSH
- sklerozující cholangitida * imunologie krev komplikace genetika MeSH
- studie případů a kontrol MeSH
- žlučové kyseliny a soli * krev imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- žlučové kyseliny a soli * MeSH
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case-control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.
Department of Biochemistry and Genetics School of Sciences University of Navarra Pamplona Spain
Division of Gastroenterology Hospital Beatriz Ângelo Loures Portugal
Division of Gastroenterology Hospital da Luz Lisboa Portugal
Division of Gastroenterology Hospital Lusíadas Lisboa Portugal
Division of Gastroenterology ULS Santa Maria Lisboa Portugal
Experimental Hepatology and Drug Targeting University of Salamanca Salamanca Spain
Ikerbasque Basque Foundation for Science Bilbao Spain
Research Institute for Medicines Faculty of Pharmacy Universidade de Lisboa Lisboa Portugal
Citace poskytuje Crossref.org
