Aspergillus latus: a cryptic causative agent of aspergillosis emerging in Japan
Status Publisher Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
40493449
DOI
10.1093/mmy/myaf052
PII: 8159885
Knihovny.cz E-zdroje
- Klíčová slova
- Aspergillus latus, Aspergillus spinulosporus, Aspergillus sublatus, aspergillosis, section Nidulantes,
- Publikační typ
- časopisecké články MeSH
Allodiploid hybrid species, Aspergillus latus, belonging to section Nidulantes, is a hybrid of A. spinulosporus and unknown species closely related to A. quadrilineatus and A. sublatus. This hybrid has often been misidentified as the species in section Nidulantes, such as A. nidulans, A. spinulosporus, A. sublatus, or other cryptic species. A. latus has not been reported in Japan as well as Asia so far. In this study, we screened 23 clinical strains identified as A. spinulosporus isolated in Japan from 2012 to 2023 and found seven A. latus strains. To characterize the A. latus strains, we conducted comprehensive phenotyping including morphological observation, whole genome sequences and phylogenetic analysis based on calmodulin (CaM) gene. In addition, we conducted antifungal susceptibility testing for A. latus strains. As a result, the morphological characters of A. latus were more similar to those of A. spinulosporus compared to A. sublatus. However, the ascospore of A. latus differed from that of A. spinulosporus. A. latus phylogenetically clustered with A. spinulosporus and A. sublatus. Furthermore, A. latus strains showed reduced susceptibility to caspofungin and amphotericin B compared to A. spinulosporus, while they were susceptible to azoles. Our results suggest that A. latus has been a causative pathogen of aspergillosis in Japan since 2013.
Aspergillus species are the causal agents for aspergillosis. We present the first report of allodiploid hybrid species A. latus being isolated in Japan through screening of A. spinulosporus strains. A. latus has been the causative agent of aspergillosis in Japan since 2013.
Department of Botany Faculty of Science Charles University Benátská 2 128 00 Prague 2 Czech Republic
Faculty of Science Chiba University 1 33 Yayoi cho Inage ku Chiba 263 8522 Japan
Medical Mycology Research Center Chiba University 1 8 1 Inohana Chuo ku Chiba 260 8673 Japan
Molecular Chirality Research Center Chiba University 1 33 Yayoi cho Inage ku Chiba 263 8522 Japan
Plant Molecular Science Center Chiba University 1 8 1 Inohana Chuo ku Chiba 260 8675 Japan
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