Structure of L-arginine and detection of trace DL-arginine by 3D ED
Status PubMed-not-MEDLINE Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
40539938
PubMed Central
PMC12231504
DOI
10.1107/s2053229625005091
PII: S2053229625005091
Knihovny.cz E-resources
- Keywords
- 3D ED, 3D electron crystallography, crystal structure, l-arginine, trace impurity,
- Publication type
- Journal Article MeSH
3D electron crystallography has emerged as a method with great potential for the structure determination of small molecules and macromolecules complementing traditional single-crystal X-ray crystallography and powder X-ray diffraction (PXRD). It offers the unique capability of determining the structures of small molecules and macromolecules from micro- and nanocrystals. In this study, using 3D electron diffraction (3D ED), we determined the single-crystal structure of commercially sourced arginine directly from its bottle. The 3D ED analysis of micro-sized single crystals identified two distinct forms: the L-arginine enantiomer and the racemic mixture DL-arginine. At the time of writing, neither the Cambridge Structural Database nor the Crystallographic Open Database contain a single-crystal structure of isolated L-arginine (sum formula C6H14N4O2), which has been solved in this work by 3D ED. We also present a comparison of the structures of these molecules solved by 3D ED and PXRD.
ELI ERIC ELI Beamlines Facility Dolni Brezany Czech Republic
Vienna Doctoral School in Chemistry University of Vienna Währinger Strasse 42 Vienna 1090 Austria
See more in PubMed
Clabbers, M. T. B., Gruene, T., van Genderen, E. & Abrahams, J. P. (2019). PubMed PMC
Courvoisier, E., Williams, P. A., Lim, G. K., Hughes, C. E. & Harris, K. D. (2012). PubMed
Danelius, E., Bu, G., Wieske, H. & Gonen, T. (2023). PubMed PMC
Deschamps, J. R. (2010). PubMed PMC
Fröjdh, E., Wennmacher, J. T. C., Rzepka, P., Mozzanica, A., Redford, S., Schmitt, B., van Bokhoven, J. A. & Gruene, T. (2020).
Gemmi, M., Mugnaioli, E., Gorelik, T. E., Kolb, U., Palatinus, L., Boullay, P., Hovmöller, S. & Abrahams, J. P. (2019). PubMed PMC
Gruene, T., Wennmacher, J. T. C., Zaubitzer, C., Holstein, J. J., Heidler, J., Fecteau–Lefebvre, A., De Carlo, S., Müller, E., Goldie, K. N., Regeni, I., Li, T., Santiso–Quinones, G., Steinfeld, G., Handschin, S., van Genderen, E., van Bokhoven, J. A., Clever, G. H. & Pantelic, R. (2018). PubMed PMC
Habermehl, S., Mörschel, P., Eisenbrandt, P., Hammer, S. M. & Schmidt, M. U. (2014). PubMed
Harris, K. D. (2012). PubMed
Harris, K. D., Tremayne, M. & Kariuki, B. M. (2001). PubMed
Hübschle, C. B., Sheldrick, G. M. & Dittrich, B. (2011). PubMed PMC
Hughes, C. E., Boughdiri, I., Bouakkaz, C., Williams, P. A. & Harris, K. D. (2018).
Jones, C. G., Martynowycz, M. W., Hattne, J., Fulton, T. J., Stoltz, B. M., Rodriguez, J. A., Nelson, H. M. & Gonen, T. (2018). PubMed PMC
Khakurel, K. P., Angelov, B. & Andreasson, J. (2019). PubMed PMC
Kingsford-Adaboh, R., Grosche, M., Dittrich, B. & Luger, P. (2000). PubMed
Klar, P. B., Krysiak, Y., Xu, H., Steciuk, G., Cho, J., Zou, X. & Palatinus, L. (2023). PubMed PMC
Niitsu, N., Mitani, M., Ishii, H., Kobayashi, N., Hirose, K., Watanabe, S., Okamoto, T. & Takeya, J. (2024).
Palatinus, L., Brázda, P., Boullay, P., Perez, O., Klementová, M., Petit, S., Eigner, V., Zaarour, M. & Mintova, S. (2017). PubMed
Pan, Q., Guo, P., Duan, J., Cheng, Q. & Li, H. (2012).
Prince, E. (2004). Editor.
Sheldrick, G. M. (2015
Sheldrick, G. M. (2015
Spiliopoulou, M., Valmas, A., Triandafillidis, D.-P., Kosinas, C., Fitch, A., Karavassili, F. & Margiolaki, I. (2020).
Unge, J., Lin, J., Weaver, S. J., Sae Her, A. & Gonen, T. (2024). PubMed PMC
Williams, P. A., Hughes, C. E. & Harris, K. D. (2015). PubMed
Yonekura, K., Kato, K., Ogasawara, M., Tomita, M. & Toyoshima, C. (2015). PubMed PMC
