Interaction between expression of CD23 on B-lymphocytes and level of specific IgE against molecular components of NPC2 family, lipocalins, uteroglobins, and molecular components of molds and yeast
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Atopic dermatitis, CD23 molecule on B lymphocytes, specific IgE against molecular components,
- MeSH
- Allergens immunology MeSH
- Dermatitis, Atopic * immunology drug therapy MeSH
- B-Lymphocytes * immunology MeSH
- Child MeSH
- Adult MeSH
- Fungi immunology MeSH
- Antibodies, Monoclonal, Humanized therapeutic use MeSH
- Immunoglobulin E * blood immunology MeSH
- Cats MeSH
- Yeasts immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Dogs MeSH
- Receptors, IgE * metabolism immunology MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Cats MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Dogs MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Allergens MeSH
- dupilumab MeSH Browser
- Antibodies, Monoclonal, Humanized MeSH
- Immunoglobulin E * MeSH
- Receptors, IgE * MeSH
The aim of this study was to assess the relationship between the expression of the CD23 molecule on B-cells and the levels of specific IgE against allergens and molecular components of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimp (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in atopic dermatitis (AD) patients (with and without dupilumab therapy). Here, 46 patients with AD were included (26 without dupilumab treatment, 20 with dupilumab treatment). Serum levels of specific IgE were measured using the component-resolved diagnostic microarray ALEX2 Allergy Xplorer, and the expression of the CD23 molecule on B-cells was evaluated using flow cytometry. For statistical analysis, a Spearman's rank correlation was used. The data indicated there was a higher correlation between CD23 expression on B-cells and specific IgE against molecular components of storage mites Bla g 9 (up to 27%), cat Fel d 1 (22.7%), and allergen extract Cla h (Cladosporium herbarum) up to 38.9% in AD patients treated with dupilumab. These results regarding the higher association suggested a significant role in the non-inflammatory clearance and uptake of these specific IgE antibodies.
What is already known about this topic? It is not yet known whether the expression of molecule CD23 on B-cells is related to the level of allergen-specific IgE antibodies in AD patients. It is also not yet known what role dupilumab may have on this receptor.What does this article add to our knowledge? The study investigated the relationship between CD23 expression on B-cells and specific IgE levels of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimps (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in patients with atopic dermatitis (AD), both with and without dupilumab treatment.How does this study impact current management guidelines? The study provides insights into how dupilumab influences IgE interactions and allergic inflammation, potentially guiding more targeted treatments for AD patients. The findings suggest that dupilumab therapy may be more effective in AD patients sensitized to allergen extract Cla h (Cladosporium herbarum) due to its role in reducing inflammatory responses.
Department of Medical Biophysics Medical Faculty of Charles University Hradec Králové Czech Republic
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