Interaction between expression of CD23 on B-lymphocytes and level of specific IgE against molecular components of NPC2 family, lipocalins, uteroglobins, and molecular components of molds and yeast
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Atopic dermatitis, CD23 molecule on B lymphocytes, specific IgE against molecular components,
- MeSH
- alergeny imunologie MeSH
- atopická dermatitida * imunologie farmakoterapie MeSH
- B-lymfocyty * imunologie MeSH
- dítě MeSH
- dospělí MeSH
- houby imunologie MeSH
- humanizované monoklonální protilátky terapeutické užití MeSH
- imunoglobulin E * krev imunologie MeSH
- kočky MeSH
- kvasinky imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- psi MeSH
- receptory IgE * metabolismus imunologie MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kočky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alergeny MeSH
- dupilumab MeSH Prohlížeč
- humanizované monoklonální protilátky MeSH
- imunoglobulin E * MeSH
- receptory IgE * MeSH
The aim of this study was to assess the relationship between the expression of the CD23 molecule on B-cells and the levels of specific IgE against allergens and molecular components of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimp (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in atopic dermatitis (AD) patients (with and without dupilumab therapy). Here, 46 patients with AD were included (26 without dupilumab treatment, 20 with dupilumab treatment). Serum levels of specific IgE were measured using the component-resolved diagnostic microarray ALEX2 Allergy Xplorer, and the expression of the CD23 molecule on B-cells was evaluated using flow cytometry. For statistical analysis, a Spearman's rank correlation was used. The data indicated there was a higher correlation between CD23 expression on B-cells and specific IgE against molecular components of storage mites Bla g 9 (up to 27%), cat Fel d 1 (22.7%), and allergen extract Cla h (Cladosporium herbarum) up to 38.9% in AD patients treated with dupilumab. These results regarding the higher association suggested a significant role in the non-inflammatory clearance and uptake of these specific IgE antibodies.
What is already known about this topic? It is not yet known whether the expression of molecule CD23 on B-cells is related to the level of allergen-specific IgE antibodies in AD patients. It is also not yet known what role dupilumab may have on this receptor.What does this article add to our knowledge? The study investigated the relationship between CD23 expression on B-cells and specific IgE levels of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimps (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in patients with atopic dermatitis (AD), both with and without dupilumab treatment.How does this study impact current management guidelines? The study provides insights into how dupilumab influences IgE interactions and allergic inflammation, potentially guiding more targeted treatments for AD patients. The findings suggest that dupilumab therapy may be more effective in AD patients sensitized to allergen extract Cla h (Cladosporium herbarum) due to its role in reducing inflammatory responses.
Department of Medical Biophysics Medical Faculty of Charles University Hradec Králové Czech Republic
Citace poskytuje Crossref.org
