Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
Fonds de recherche du Québec - Santé, the Canadian Institutes of Health Research, the W. Garfield Weston Foundation, the Michael J. Fox Foundation for Parkinson's Research, and the National Institutes of Health
Canada Research Chair in Cognitive Decline in Pathological Aging
CIHR, Michael J. Fox Foundation, NIH, Roche Diagnostics, and the Weston Foundation
NU21-04-00535
Czech Health Research Council
LX22NPO5107
National Institute for Neurological Research
European Union - Next Generation EU
National Institute for Health and Care Research (NIHR) Oxford Health Clinical Research Facility and the NIHR Oxford Biomedical Research Centre
IHU (IAIHU-06)
the Paris Institute of Neurosciences
ANR-11-INBS-0006
Agence Nationale de la Recherche
Control-PD (JPND Cognitive Propagation in Prodromal Parkinson's Disease)
Parkinson's UK, the Oxford Biomedical Research Centre, CPT, EPND, and the Michael J. Fox Foundation
Michael J. Fox Foundation
4D Pharma, AbbVie Inc., AcureX Therapeutics, Allergan, Amathus Therapeutics, Aligning Science Across Parkinson's (ASAP), Avid Radiopharmaceuticals, Bial Biotech, Biogen, BioLegend, Bristol Myers Squibb, Calico Life Sciences LLC, Celgene Corporation, DaCapo Brainscience, Denali Therapeutics, The Edmond J. Safra Foundation, Eli Lilly and Company, GE Healthcare, GlaxoSmithKline, Golub Capital, Handl Therapeutics, Insitro, Janssen Pharmaceuticals, Lundbeck, Merck & Co., Inc., Meso Scale Diagnostics, LLC, Neurocrine Biosciences, Pfizer Inc., Piramal Imaging, Prevail Therapeutics, F. Hoffmann-La Roche Ltd
Genentech Inc., Sanofi Genzyme, Servier, Takeda Pharmaceutical Company, Teva Neuroscience, Inc., UCB, Vanqua Bio, Verily Life Sciences, Voyager Therapeutics, Inc., and Yumanity Therapeutics, Inc
0000000082
Alzheimer Society Canada
2023-0000000122
Parkinson Canada
J-2101
Parkinson's UK - United Kingdom
National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)
NIHR Oxford Health Clinical Research Facility
NIHR Oxford Biomedical Research Centre (BRC)
Department of Health and Social Care
Financed by European Union - Next Generation EU
ANR-10-IAIHU-06
Programme d'investissements d'avenir
ANR-10-IAIHU-06
Programme d'investissements d'avenir
IAIHU-06
Paris Institute of Neurosciences - IHU
Électricité de France (Fondation d'Entreprise EDF)
Control-PD (Joint Programme-Neurodegenerative Disease Research [JPND] Cognitive Propagation in Prodromal Parkinson's disease)
Fondation Thérèse et René Planiol
Fonds Saint-Michel
Parkinson's disease from Energipole (M. Mallart)
Société Française de Médecine Esthétique (M. Legrand)
Institut de France to Isabelle Arnulf (for the ALICE Study)
Canadian Institutes of Health Research (CIHR)
Fonds de recherche du Québec - Santé (FRQ-S)
W. Garfield Weston Foundation
PPG-2023-0000000122
Parkinson Society Canada
PubMed
40791089
PubMed Central
PMC12340432
DOI
10.1002/alz.70574
Knihovny.cz E-zdroje
- Klíčová slova
- dementia with Lewy bodies, diffusion magnetic resonance imaging, graph theory, parasomnias, sleep, structural connectivity, synucleinopathies,
- MeSH
- demence s Lewyho tělísky * diagnostické zobrazování patofyziologie MeSH
- difuzní magnetická rezonance MeSH
- konektom MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozek * diagnostické zobrazování patologie MeSH
- nervová síť * diagnostické zobrazování MeSH
- Parkinsonova nemoc diagnostické zobrazování patofyziologie MeSH
- polysomnografie MeSH
- porucha chování v REM spánku * diagnostické zobrazování patofyziologie patologie MeSH
- prospektivní studie MeSH
- senioři MeSH
- zobrazování difuzních tenzorů MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
INTRODUCTION: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD), characterized by abnormal movements during REM sleep, is a prodromal stage of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). While iRBD shows emerging brain changes, their impact on structural connectivity and network efficiency, and their predictive value, remain poorly characterized. METHODS: In this international prospective study, 198 polysomnography-confirmed iRBD patients and 174 controls underwent diffusion magnetic resonance imaging and were analyzed. Cutting-edge diffusion tractography and network-based statistics were applied to reconstruct individual connectomes and assess network properties predicting DLB or PD. RESULTS: Structural architecture was already disrupted in iRBD, with both reduced and compensatory increased connections. Global efficiency was decreased. Local efficiency in motor regions was altered and associated with early clinical symptoms. Altered local efficiency in the supramarginal gyrus predicted DLB only. DISCUSSION: Early disruption of brain architecture in iRBD predicts progression to synucleinopathy-related dementia, offering a novel potential prognostic biomarker. HIGHLIGHTS: Isolated rapid eye movement sleep behavior disorder (iRBD) patients show significant alterations in inter-regional structural connectivity. Global efficiency is reduced in iRBD compared to controls. Areas with increased local efficiency contribute to decreased global efficiency. Altered network efficiency is associated with emerging Parkinsonian features. Higher supramarginal efficiency predicts dementia with Lewy bodies in iRBD.
Department of Medicine University of Montreal Montreal Québec Canada
Department of Neurology Montreal General Hospital Montreal Québec Canada
Department of Neuroscience University of Montreal Montreal Québec Canada
Department of Psychology Université du Québec à Montréal Montreal Québec Canada
Research Centre Institut Universitaire de Gériatrie de Montréal Montreal Québec Canada
Sherbrooke Connectivity Imaging Lab Université de Sherbrooke Sherbrooke Québec Canada
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